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Source: Journal of the Neurological Sciences
Condition: Ischemic Stroke
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Total 394 results found since Jan 2013.
Clinical significance of changes in serum neuroglobin and HIF-1 α concentrations during the early-phase of acute ischemic stroke
Neuroglobin (NGB) has been described as a neuroprotective agent in cerebral ischemia, hypoxia inducible factor (HIF) has shown an important role in modulating hypoxic and ischemic injury, and therefore they have the potential to impact outcomes after acute ischemic stroke (AIS). Thus, we investigated early changes in the concentrations of serum NGB and HIF-1 α after AIS and evaluated the relations of both NGB and HIF-1α to stroke severity and prognosis.
Source: Journal of the Neurological Sciences - January 13, 2017 Category: Neurology Authors: Lixia Xue, Hao Chen, Kaili Lu, Jiankang Huang, Hao Duan, Yuwu Zhao Source Type: research
Risk assessment of cerebral microbleeds and white matter hyperintensities in patients with non-valvular atrial fibrillation
Charidimou et al. conducted a prospective study to investigate the effect of cerebral microbleeds (CMBs) and white matter hyperintensities (WMH) on subsequent stroke in 119 patients with non-valvular atrial fibrillation [1]. The authors used multivariable Cox regression analyses. CMBs were found in 26 patients and moderate to severe WMH were found in 27 patients. During a median follow-up time of 17months, 14 patients experienced an ischemic stroke and 3 patients experienced intracerebral hemorrhage.
Source: Journal of the Neurological Sciences - January 5, 2017 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research
Glucose and stroke: What about glycemic variability?
I read with great pleasure the paper by Osei et al. [1] reporting that admission hyperglycemia was associated with a worse functional outcome in patients with acute ischemic stroke (AIS) undergoing endovascular treatment (the MR CLEAN protocol). The results are similar to those reported by the Solitaire Flow Restoration With the Intention for Thrombectomy (SWIFT) investigators [2], where patients with hyperglycemia on presentation less frequently exhibited an excellent outcome at 3months than patients without hyperglycemia (13% versus 34%; p=0.01).
Source: Journal of the Neurological Sciences - January 4, 2017 Category: Neurology Authors: Carlos R. Camara-Lemarroy Tags: Letter to the Editor Source Type: research
Lack of association between MCP-1 -2518A/G polymorphism and ischemic stroke: From a case-control study to an updated meta-analysis
Monocyte chemotactic protein-1 (MCP-1), a member of chemokine family, recruits monocytes into the subendothelial space, subsequently causing their differentiation to macrophages and involvement in the initiation and progression of vascular inflammation [1]. A polymorphic G allele at the -2518A/G position in the promoter region of MCP-1 gene has been shown to affect the expression of MCP-1 [2]. Several studies revealed the association of MCP-1 -2518A/G polymorphism with ischemic stroke (IS) [3,4].
Source: Journal of the Neurological Sciences - December 21, 2016 Category: Neurology Authors: Xu Liu, Ruixia Zhu, Qu Li, Zhiyi He Tags: Letter to the Editor Source Type: research
Clopidogrel and ischemic stroke outcomes by smoking status: Smoker's paradox?
Active smokers with myocardial infarction were shown to have enhanced benefit with clopidogrel compared with aspirin. Whether this “paradox” exists in ischemic stroke patients is unknown. We aimed to investigate whether smoking status has a differential impact on the efficacy of clopidogrel vs. aspirin in patients with non-cardioembolic strokes.
Source: Journal of the Neurological Sciences - December 16, 2016 Category: Neurology Authors: Qian Zhang, Yuan Wang, Haiqing Song, Chengbei Hou, Qingyu Cao, Kai Dong, Xiaoqin Huang, Wuwei Feng, Bruce Ovbiagele, Moli Wang, Xunming Ji Source Type: research
Hemorrhagic transformation and cerebral edema in acute ischemic stroke: Link to cerebral autoregulation
We examined the relationship between dynamic cerebral autoregulation (CA) in the early hours post ischemia, and the risk of developing hemorrhagic transformation and cerebral edema at 24h post stroke
Source: Journal of the Neurological Sciences - November 28, 2016 Category: Neurology Authors: Pedro Castro, Elsa Azevedo, Jorge Serrador, Isabel Rocha, Farzaneh Sorond Source Type: research
Stroke severity may predict causes of readmission within one year in patients with first ischemic stroke event
Readmissions after stroke are costly. Risk assessment using information available upon admission could identify high-risk patients for potential interventions to reduce readmissions. Baseline stroke severity has been suspected to be a factor in readmission; however, the exact nature of the impact has not been adequately understood.
Source: Journal of the Neurological Sciences - November 14, 2016 Category: Neurology Authors: Cheng-Yang Hsieh, Huey-Juan Lin, Ya-Han Hu, Sheng-Feng Sung Source Type: research
MRI based thrombolysis for FLAIR-negative stroke patients within 4.5 –6h after symptom onset
To investigate the feasibility of DWI-FLAIR mismatch in identifying patients who might benefit from thrombolytic therapy within 4.5 –6h, we analyzed the data of 105 ischemic stroke patients with known time of symptom onset who underwent MRI within 6h of stroke and thrombolysis between December 2006 and December 2013. They were divided into three groups: symptom onset within 4.5h (n=66); 4.5–6h and FLAIR images negative (n=9) ; and 4.5–6h and FLAIR images positive (n=30). Outcome of thrombolysis was assessed for each group by recanalization rate, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores.
Source: Journal of the Neurological Sciences - November 8, 2016 Category: Neurology Authors: Xiao-Er Wei, Jia Zhou, Wen-Bin Li, Yu-Wu Zhao, Ming-Hua Li, Yue-Hua Li Source Type: research
Albuminuria predicts early neurological deterioration in patients with acute ischemic stroke
Reduced glomerular filtration rate (GFR) and albuminuria have been independently associated with an increased risk of stroke and unfavorable long-term outcomes. However, the association between GFR, albuminuria, and early neurological deterioration (END) in patients with ischemic stroke has not been well studied to date. We therefore investigated the ability of estimated GFR (eGFR) and albuminuria to predict END in patients with acute ischemic stroke.
Source: Journal of the Neurological Sciences - November 4, 2016 Category: Neurology Authors: Takuya Kanamaru, Satoshi Suda, Kanako Muraga, Seiji Okubo, Yoko Watanabe, Syuichi Tsuruoka, Kazumi Kimura Source Type: research
Ischemic stroke due to internal carotid artery dissection associated with an elongated styloid process (Eagle syndrome)
Dear Editor,
Source: Journal of the Neurological Sciences - October 31, 2016 Category: Neurology Authors: Benjamin Hebant, Evelyne Guegan-Massardier, Val érie Macaigne, Aude Triquenot-Bagan Tags: Letter to the Editor Source Type: research
Reply to effect of CYP2C19*2 and *3 on clinical outcome in ischemic stroke patients treated with Clopidogrel
We read with great interest the recent publication of Wang et al. [1] evaluating the relationship between CYP2C19 genotypes with nonfatal ischemic stroke, myocardial infarction, or vascular death. The striking finding of this study was that the presence of CYP2C19 loss of function (LOF) alleles may increase the recurrent risk of ischemic events. The polymorphisms of CYP2C19 may be predictors of poor functional outcome of patients without stent and the effect may be weakened by time [1]. Similarly, the authors recently demonstrated that in patients with transient ischemic attack (TIA) or minor stroke who can be treated with...
Source: Journal of the Neurological Sciences - October 31, 2016 Category: Neurology Authors: Demetrios Moris, Chris Bakoyiannis, Georgios Karaolanis, Sotirios Georgopoulos Tags: Letter to the Editor Source Type: research
Response to the letter by Dr. Demetrios Moris “Reply to Effect of CYP2C19*2 and *3 on clinical outcome in ischemic stroke patients treated with clopidogrel”
“Aspirin resistance” is a poor pharmacological term which should be used when aspirin is unable to hit its molecular target – the platelet cyclooxygenase (COX)-1. However, this type of resistance is rare and in the range of 1% or less [1–2]. This term frequently mixed up with clinical treatm ent failure in an inappropriate way [3]. Therefore, patients with poor aspirin response should not be considered resistant or non-resistant. Using “aspirin treatment failure” may be more appropriate.
Source: Journal of the Neurological Sciences - October 31, 2016 Category: Neurology Authors: Yingting Wang, Huan Cai, Guoqing Zhou, Zhizhong Zhang, Xinfeng Liu Tags: Response to Letter to the Editor Source Type: research
Increased admission and fasting glucose are associated with unfavorable short-term outcome after intra-arterial treatment of ischemic stroke in the MR CLEAN pretrial cohort
Limited data are available on the impact of fasting glucose on outcome after intra-arterial treatment (IAT). We studied whether hyperglycemia on admission and impaired fasting glucose (IFG) are associated with unfavorable outcome after IAT in acute ischemic stroke.
Source: Journal of the Neurological Sciences - October 5, 2016 Category: Neurology Authors: E. Osei, H.M. den Hertog, O.A. Berkhemer, P.S.S. Fransen, Y.B.W.E.M. Roos, D. Beumer, R.J. van Oostenbrugge, W.J. Schonewille, J. Boiten, A.A.M. Zandbergen, P.J. Koudstaal, D.W.J. Dippel, MR CLEAN pretrial investigators Source Type: research
Hypertrophic olivary degeneration: Case series and review of literature
Hypertrophic Olivary Degeneration (HOD) is a rare neurological condition caused by trans-synaptic degeneration in the brainstem and cerebellum, resulting in varied clinical symptoms, classical being palatal tremors, along with characteristic imaging presentation. Large number of pathologic lesions can cause this condition, ranging from ischemic stroke to neoplasm. The most common conditions include hemorrhage, vascular malformations and infarct. Magnetic resonance scan (MRI) is the imaging modality of choice which shows signal changes with hypertrophy of the inferior olivary nucleus, as well as the primary underlying pathology.
Source: Journal of the Neurological Sciences - September 26, 2016 Category: Neurology Authors: Shyam Sabat, Neil Mannering, Amit Agarwal Tags: Review Article Source Type: research
Recombinant tissue plasminogen activator enhances microparticle release from mouse brain-derived endothelial cells through plasmin
Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is currently the only approved pharmacological strategy for acute ischemic stroke. However, rt-PA exhibits vascular toxicity mainly due to endothelial damage. To investigate the mechanisms underlying rt-PA-induced endothelial alterations, we assessed the role of rt-PA in the generation of endothelial microparticles (EMPs), emerging biological markers and effectors of endothelial dysfunction.The mouse brain-derived endothelial cell line bEnd.3 was used.
Source: Journal of the Neurological Sciences - September 15, 2016 Category: Neurology Authors: Marie Garraud, Kahina Khacef, Anne-Cl émence Vion, Claire Leconte, Min Yin, Jean-Marie Renard, Catherine Marchand-Leroux, Chantal M. Boulanger, Isabelle Margaill, Virginie BERAY-Berthat Source Type: research
