• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Association between plasma trimethylamine-N-oxide and cognitive impairment in patients with transient ischemic attack
CONCLUSION: Plasma TMAO at baseline was independently associated with cognitive impairment at the 3-month follow-up after TIA. In addition, the inflammatory marker CRP may serve as an important mediator in this relationship. Our study may provide some insights into anti-inflammatory therapy to improve the cognitive trajectory of TIA patients with high TMAO levels.PMID:36789535 | DOI:10.1080/01616412.2023.2176632
Source: Neurological Research - February 15, 2023 Category: Neurology Authors: Lufeng Wang Xiaopeng Zhan Li Jiang Guangyu Xu Yiwen Bao Junlang Wang Shaohua Qv Jie Yang Dongya Huang Source Type: research

Motor outcome of deep intracerebral haemorrhage in diffusion tensor imaging: comparison of data from different locations along the corticospinal tract.
DISCUSSION: Clinical motor outcome of ICH within 2 weeks can be identified with a statistically significant decrease in rFA at the corona radiata. PMID: 26003992 [PubMed - as supplied by publisher]
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Clinical features and outcomes in 154 patients with haemorrhagic moyamoya disease: comparison of conservative treatment and surgical revascularization.
CONCLUSIONS: Age at the initial bleeding is a risk factor for rebleeding in haemorrhagic MMD. Although surgical revascularization showed the tendency to decrease the rebleeding rate, there was no statistical difference between direct revascularization, indirect revascularization, combined revascularization and conservative treatment in preventing rebleeding. Further study is needed to determine whether surgical revascularization is effective in select population or with certain techniques. PMID: 26159234 [PubMed - as supplied by publisher]
Source: Neurological Research - July 12, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by combination of resveratrol and enriched environment against ischemic brain injury in rats.
DISCUSSION: Altogether, the combined therapy of RV and EE showed a clearly enhanced neuroprotective effect, compared to RV or EE monotherapy, which might be a new strategy for the treatment of ischemic brain injury. PMID: 26883584 [PubMed - as supplied by publisher]
Source: Neurological Research - February 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats.
In this study, we aimed to evaluate the effect of the Ischemic preconditioning (IPreC) on the expression profile of cerebral miRNAs against stroke by induced transient middle cerebral artery occlusion (MCAo) in diabetic rats. METHODS: Eighty male Spraque Dawley rats were allocated to eight groups. In order to evaluate the expression profile of miRNAs, we induced transient MCAo seven days after STZ-induced diabetes (DM). Also we performed IPreC 72 h before transient MCAo to assess whether IPreC could have a neuroprotective effect against ischemia-reperfusion injury. RESULTS: The general characteristics of STZ-treat...
Source: Neurological Research - September 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia.
This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monkeys by right unilateral middle cerebral artery (MCA) occlusion by the transorbital technique. Following occlusion of the right MCA, monkeys were randomized into one of the following treatment groups: Group A - Fluosol-DA 15 ml kg(-1) i.v. + 40% O2; Group B - Fluosol-DA 15 ml kg(-1) i.v. + 100% O2; Group C-hetas...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.
CONCLUSION: These results showed that UTI protected the brain against ischemic injury which may be due to the alleviation of inflammation reaction in early stage through downregulating TLR4 and NF-κB expression. PMID: 28191863 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Intraluminal spindle-shaped-head suture induced occlusion of middle cerebral artery in the rats.
CONCLUSION: Our findings indicate that the modified suture induces a more reproducible and stable ischemic stroke following MCAO in SD rats. PMID: 28936922 [PubMed - as supplied by publisher]
Source: Neurological Research - September 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research

U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors.
CONCLUSION: These findings suggest a novel mechanism by which the ERK1/2 signaling pathway affects the post-I/R apoptosis of CA1 pyramidal neurons, which will provide a therapeutic target for the treatment of stroke. PMID: 29473447 [PubMed - as supplied by publisher]
Source: Neurological Research - February 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The changes of systemic immune responses during the neuroprotection induced by remote ischemic postconditioning against focal cerebral ischemia in mice.
CONCLUSIONS: The present study indicates that there were significant changes of inflammatory responses during the neuroprotection induced by RIPostC in stroke mice. PMID: 30281410 [PubMed - as supplied by publisher]
Source: Neurological Research - October 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of intracranial and extracranial atherosclerotic lesions in patients with symptomatic coronary artery disease.
Conclusions: The prevalence of ECAD, ICAD and EICAD is high in patients with CAD, and the presence of these conditions is positively correlated with the extent and degree of CAD. Evaluations of ECAD and ICAD should be highly recommended for CAD patients to reduce the future risk of cardiovascular diseases. PMID: 32284016 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF- κB signaling pathway inhibition.
Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition. Neurol Res. 2020 Jul 13;:1-10 Authors: Fan X, Elkin K, Shi Y, Zhang Z, Cheng Y, Gu J, Liang J, Wang C, Ji X Abstract It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted from Schisandra chinensis, has been shown to posse...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20