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Increased risk of stroke and myocardial infarction in patients with epilepsy: A systematic review of population-based cohort studies.
CONCLUSIONS: Patients with epilepsy are at higher risk of subsequent stroke and MI in comparison with subjects without epilepsy. Although individual AEDs may carry different risks of cardio- and cerebrovascular disease, the clinical relevance of the metabolic effects of the enzyme-inducing AEDs is still uncertain. This article is part of the Special Issue "Seizures & Stroke. PMID: 31182394 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 6, 2019 Category: Neurology Authors: Brigo F, Lochner P, Nardone R, Manganotti P, Lattanzi S Tags: Epilepsy Behav Source Type: research

Increased risk of stroke and myocardial infarction in patients with epilepsy: A systematic review of population-based cohort studies
ConclusionsPatients with epilepsy are at higher risk of subsequent stroke and MI in comparison with subjects without epilepsy. Although individual AEDs may carry different risks of cardio- and cerebrovascular disease, the clinical relevance of the metabolic effects of the enzyme-inducing AEDs is still uncertain.This article is part of the Special Issue “Seizures & Stroke
Source: Epilepsy and Behavior - June 8, 2019 Category: Neurology Source Type: research

Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
Abstract Stroke is a neurological condition and may cause changes in hepatic drug-metabolizing enzymes. Hepatic CYP2B is involved in the metabolism of a variety of centrally active substances. The purpose of this study was to investigate the possible down-regulation mechanism of hepatic CYP2B after acute stroke. Using a rat model of acute stroke induced by middle cerebral artery occlusion, we studied the influence of brain ischemia/reperfusion (I/R) injury on CYP2B expression. Effects of 3,5,3'-triiodo-L-thyronine (T3) treatment on constitutive androstane receptor (CAR) and thyroid hormone receptors (TRs, includin...
Source: Biochemical Pharmacology - December 21, 2013 Category: Drugs & Pharmacology Authors: Bing Y, Zhu S, Jiang K, Dong G, Li J, Yang Z, Yang J, Yue J Tags: Biochem Pharmacol Source Type: research

Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review
CONCLUSIONS: Our review shows that the use of ASMs that act throughout a gabaergic mechanism are inadequate in controlling seizures secondary to neonatal stroke in full-term newborns. Very effective seems to be lidocaine and levetiracetam with an apparent safer profile in short and long term. Bumetanide shows promising results, but they need to be confirmed by phase 3 studies.PMID:36533757 | DOI:10.23750/abm.v93i6.13440
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Vincenzo Sortino Andrea Pratic ò Silvia Marino Roberta Criscione Martino Ruggieri Francesco Pisani Raffaele Falsaperla Source Type: research

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