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Clinical Evaluation of Deployed Military Personnel with Chronic Respiratory Symptoms: STAMPEDE (Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures) III.
CONCLUSION: Post-deployment pulmonary evaluation should focus on common diseases such as asthma and airway hyperreactivity, and include testing for upper airway disorders. Diffuse lung diseases were rarely diagnosed while numerous co-morbidities were common. PMID: 32017933 [PubMed - as supplied by publisher]
Source: Chest - January 31, 2020 Category: Respiratory Medicine Authors: Morris MJ, Walter RJ, McCann ET, Sherner JH, Murillo C, Barber B, Hunninghake JC, Holley AB Tags: Chest Source Type: research

Antileukotrienes improve naso ‐ocular symptoms and biomarkers in patients with NARES and asthma
ConclusionNARES patients may benefit from treatment with montelukast. In particular, the presence of concomitant asthma may be predictive of a greater efficacy.Level of Evidence2.Laryngoscope, 2018
Source: The Laryngoscope - November 26, 2018 Category: ENT & OMF Authors: Eugenio De Corso, Roberta Anzivino, Jacopo Galli, Silvia Baroni, Walter Di Nardo, Carla De Vita, Antonio Salvati, Chiara Autilio, Stefano Settimi, Dario Mele, Gaetano Paludetti, Joaquim Mullol Tags: Allergy/Rhinology Source Type: research

Long ‐term impact of endoscopic orbital decompression on sinonasal‐specific quality of life
ConclusionEndoscopic orbital decompression is associated at 1 year with a significant improvement in sinonasal‐specific quality of life, which is driven by the psychological and sleep dysfunction domains. Adjunctive septoplasty has no significant impact on SNOT‐22 scores. Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - September 25, 2017 Category: ENT & OMF Authors: Sarina K. Mueller, Marcel M. Miyake, Daniel R. Lefebvre, Suzanne K. Freitag, Benjamin S. Bleier Tags: Allergy/Rhinology Source Type: research

Analysis of factors associated with electing endoscopic sinus surgery
ConclusionBaseline total SNOT‐22 and endoscopy scores are associated with treatment crossover, but reported sleep dysfunction is the only significant independent predictor of treatment crossover. Level of Evidence2c. Laryngoscope, 2017
Source: The Laryngoscope - August 4, 2017 Category: ENT & OMF Authors: Adam S. DeConde, Jess C. Mace, Vijay R. Ramakrishnan, Jeremiah A. Alt, Timothy L. Smith Tags: Allergy/Rhinology Source Type: research

Surgical outcome for empty nose syndrome: Impact of implantation site
ConclusionLateral nasal wall implantation may provide significantly better clinical outcomes than inferior nasal wall implantation, and thus may be the preferred, more optimal site for implant placement in ENS patients. Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - July 17, 2017 Category: ENT & OMF Authors: Ta ‐Jen Lee, Chia‐Hsiang Fu, Ching‐Lung Wu, Yi‐Chan Lee, Chi‐Che Huang, Po‐Hung Chang, Yi‐Wei Chen, Hsiao‐Jung Tseng Tags: Allergy/Rhinology Source Type: research

Impact of obstructive sleep apnea in transsphenoidal pituitary surgery: An analysis of inpatient data
ConclusionsIn patients who underwent transsphenoidal pituitary surgery, OSA was associated with higher rates of certain pulmonary and airway complications. OSA was not associated with increased non–pulmonary/airway complications or inpatient mortality, despite older average age and higher comorbidity rates. Level of Evidence2C Laryngoscope, 2017
Source: The Laryngoscope - July 3, 2017 Category: ENT & OMF Authors: Sei Y. Chung, Michael J. Sylvester, Varesh R. Patel, Michael Zaki, Soly Baredes, James K. Liu, Jean Anderson Eloy Tags: Allergy/Rhinology Source Type: research

What drives productivity loss in chronic rhinosinusitis? A SNOT ‐22 subdomain analysis
ConclusionsImpairments in sleep and psychological SNOT‐22 domains correlate with productivity losses. Patients with comorbid immunodeficiency, smoking, and steroid dependency had higher than average productivity losses. Targeted management of psychological and sleep dysfunction in combination with standard symptom control may improve patient‐centered care and reduce the annual economic burden of CRS. Level of Evidence2c Laryngoscope, 2017
Source: The Laryngoscope - June 10, 2017 Category: ENT & OMF Authors: Naweed I. Chowdhury, Jess C. Mace, Timothy L. Smith, Luke Rudmik Tags: Allergy/Rhinology Source Type: research

Low 22‐item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
ConclusionsLow‐SNOT CRS patients represent an outlier population for which measures of QoL fail to identify factors influencing the decision to seek treatment. Low‐SNOT CRS patients electing ESS have a decreased likelihood of reporting MCIDs following ESS. Further study is required to identify novel factors associated with treatment‐seeking behavior in this population. Level of Evidence3B Laryngoscope, 2016
Source: The Laryngoscope - July 4, 2016 Category: ENT & OMF Authors: Joshua M. Levy, Jess C. Mace, Luke Rudmik, Zachary M. Soler, Timothy L. Smith Tags: Allergy/Rhinology Source Type: research

Low 22 ‐item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
ConclusionsLow‐SNOT CRS patients represent an outlier population for which measures of QoL fail to identify factors influencing the decision to seek treatment. Low‐SNOT CRS patients electing ESS have a decreased likelihood of reporting MCIDs following ESS. Further study is required to identify novel factors associated with treatment‐seeking behavior in this population. Level of Evidence3B Laryngoscope, 2016
Source: The Laryngoscope - July 4, 2016 Category: ENT & OMF Authors: Joshua M. Levy, Jess C. Mace, Luke Rudmik, Zachary M. Soler, Timothy L. Smith Tags: Allergy/Rhinology Source Type: research

Nasal obstruction has a limited impact on sleep quality and quality of life in patients with chronic rhinosinusitis
ConclusionsNasal obstruction appears to have a limited association with CRS‐specific QOL and CRS‐associated decrease in SQ. Further, the NOSE instrument, because it contains a question about sleep, may have overlap with the PSQI as a measure of SQ. The total NOSE score in CRS patients does not appear to be purely a measure of nasal obstruction. Level of Evidence4 Laryngoscope, 2016
Source: The Laryngoscope - May 1, 2016 Category: ENT & OMF Authors: Andrew J. Thomas, Richard R. Orlandi, Shaelene Ashby, Jess C. Mace, Timothy L. Smith, Jeremiah A. Alt Tags: Allergy/Rhinology Source Type: research

Comorbidities in patients with all‐positive symptoms on sinonasal outcomes test quality‐of‐life instrument
ConclusionThe SNOT‐20 questionnaire assists clinicians to monitor outcomes in patients treated for CRS. However, clinicians should suspect other underlying chronic conditions in SNOT‐20 pan‐positive patients. Level of Evidence3B. Laryngoscope, 2015
Source: The Laryngoscope - July 7, 2015 Category: ENT & OMF Authors: Alexander Caten, Christopher Johnson, David Jang, Jose Gurrola, Stilianos Kountakis Tags: Allergy/Rhinology Source Type: research

Antisomnogenic cytokines, quality of life, and chronic rhinosinusitis: A pilot study
ConclusionsPatients with CRS exhibited behavioral changes commonly referred to as sickness behavior, which include poor sleep quality and reduced QOL. The upregulation of IL‐4 and TGF‐β may contribute to inflammatory brain‐mediated effects on sleep quality, whereas IL‐13 may be a pleiotropic signaling molecule influencing sleep, QOL, and CRS disease severity. Level of Evidence2b Laryngoscope, 2013
Source: The Laryngoscope - October 22, 2013 Category: ENT & OMF Authors: Jeremiah A. Alt, Nathan B. Sautter, Jess C. Mace, Kara Y. Detwiller, Timothy L. Smith Tags: Allergy/Rhinology Source Type: research

Sleep quality and disease severity in patients with chronic rhinosinusitis
ConclusionThe majority of patients with CRS have a poor quality of sleep, as measured by the PSQI survey. Poor sleep quality is significantly associated with CRS‐specific QOL, gender, comorbid depression, and tobacco use, but not CT score or endoscopy grade. Level of Evidence2b. Laryngoscope, 2013
Source: The Laryngoscope - August 5, 2013 Category: ENT & OMF Authors: Jeremiah A. Alt, Timothy L. Smith, Jess C. Mace, Zachary M. Soler Tags: Allergy/Rhinology Source Type: research