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Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

A Diagnostic Dilemma: Sometimes You ’ ll Never Know
Discussion It can be difficult to consider what is the problem when a health care provider is presented with a group of seemingly disparate signs and symptoms with a history and time course that do not match classic (or commonly atypical) disease presentations. Common things happen commonly, so when symptoms occur without the usual co-occurring symptoms, unusual symptoms or time courses, it can be challenging. The provider must develop a reasonable differential diagnosis and balance how far to go with the evaluation against how much to monitor the patient for new signs or symptoms which can provide new information. Patient...
Source: PediatricEducation.org - March 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Intramuscular versus ultrasound-guided intratenosynovial glucocorticoid injection for tenosynovitis in patients with rheumatoid arthritis: a randomised, double-blind, controlled study
Conclusions In this randomised double-blind clinical trial, patients with RA and tenosynovitis responded significantly better to US-guided intratenosynovial glucocorticoid injection than to intramuscular glucocorticoid injection, both at 4 and 12 weeks follow-up. Trial registration number EudraCT nr: 2013-003486-34.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Ammitzboll-Danielsen, M., Ostergaard, M., Fana, V., Glinatsi, D., Dohn, U. M., Ornbjerg, L. M., Naredo, E., Terslev, L. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study
Conclusions In this first international prospective study, the composite PDUS score is responsive to abatacept. GLOESS demonstrated the rapid onset of action of abatacept, regardless of the number of joints examined. Ultrasound is an objective tool to monitor patients with RA under treatment. Trial registration number NCT00767325.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: D'Agostino, M.-A., Wakefield, R. J., Berner-Hammer, H., Vittecoq, O., Filippou, G., Balint, P., Möller, I., Iagnocco, A., Naredo, E., Ostergaard, M., Boers, M., Gaillez, C., Van Holder, K., Le Bars, M., on behalf of the OMERACT-EULAR-Ultrasound Ta Tags: Open access, Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach
Conclusions The reduced GSUS and PDUS scores retained most of the information from the total score and performed well in a validation cohort of established RA. Trial registation number NCT01205854, ACTRN12610000284066.
Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Aga, A.-B., Hammer, H. B., Olsen, I. C., Uhlig, T., Kvien, T. K., van der Heijde, D., Fremstad, H., Madland, T. M., Lexberg, A. S., Haukeland, H., Rodevand, E., Hoili, C., Stray, H., Bendvold, A. N., Soldal, D. M., Bakland, G., Lie, E., Haavardsholm, E. A Tags: Immunology (including allergy), Inflammation, Radiology, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radio Source Type: research

Targeting ultrasound remission in early rheumatoid arthritis: the results of the TaSER study, a randomised clinical trial
Conclusions In early RA, a MSUS-driven T2T strategy led to more intensive treatment, but was not associated with significantly better clinical or imaging outcomes than a DAS28-driven strategy. Trial registration number NCT00920478.
Source: Annals of the Rheumatic Diseases - May 9, 2016 Category: Rheumatology Authors: Dale, J., Stirling, A., Zhang, R., Purves, D., Foley, J., Sambrook, M., Conaghan, P. G., van der Heijde, D., McConnachie, A., McInnes, I. B., Porter, D. Tags: Immunology (including allergy), Radiology, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnost Source Type: research

Analysis of distribution and severity of inflammation in patients with osteoarthitis compared to rheumatoid arthritis by ICG-enhanced fluorescence optical imaging and musculoskeletal ultrasound: a pilot study
Conclusions US and FOI detected inflammation in both RA and OA highlighting the inflammatory component in the course of OA. The different inflammatory patterns and various shapes of fluorescence enhancement in FOI may offer opportunities to distinguish and determine the inflammatory status in both diseases.
Source: Annals of the Rheumatic Diseases - February 10, 2016 Category: Rheumatology Authors: Glimm, A.-M., Werner, S. G., Burmester, G. R., Backhaus, M., Ohrndorf, S. Tags: Open access, Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and Source Type: research

EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice
To develop evidence based points to consider the use of imaging in the diagnosis and management of juvenile idiopathic arthritis (JIA) in clinical practice. The task force comprised a group of paediatric rheumatologists, rheumatologists experienced in imaging, radiologists, methodologists and patients from nine countries. Eleven questions on imaging in JIA were generated using a process of discussion and consensus. Research evidence was searched systematically for each question using MEDLINE, EMBASE and Cochrane CENTRAL. Imaging modalities included were conventional radiography, ultrasound, MRI, CT, scintigraphy and positr...
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Colebatch-Bourn, A. N., Edwards, C. J., Collado, P., D'Agostino, M.-A., Hemke, R., Jousse-Joulin, S., Maas, M., Martini, A., Naredo, E., Ostergaard, M., Rooney, M., Tzaribachev, N., van Rossum, M. A., Vojinovic, J., Conaghan, P. G., Malattia, C. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Recommendation Source Type: research

Relationship between radiographic joint space narrowing, sonographic cartilage thickness and anatomy in rheumatoid arthritis and control joints
Conclusions Sonographic cartilage assessment in MCPs is closely related to anatomical cartilage thickness. Both JSW and JSN by radiography represent cartilage thickness in the MCP joints of patients with RA quite well. Thus, US is a valid tool for measuring MCT if radiographs are not available or in case of joint malalignment.
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Mandl, P., Supp, G., Baksa, G., Radner, H., Studenic, P., Gyebnar, J., Kurucz, R., Niedermayer, D., Aletaha, D., Balint, P. V., Smolen, J. S. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Systemic inflammation and cardiovascular risk factors predict rapid progression of atherosclerosis in rheumatoid arthritis
Conclusions Systemic inflammation and CV risk factors were associated with rapid IMT progression. CV risk factors may modify the role of systemic inflammation in determining IMT progression over time. Methotrexate and antitumour necrosis factor agents may influence IMT progression by reducing the effect of the systemic inflammation on the IMT.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: del Rincon, I., Polak, J. F., O'Leary, D. H., Battafarano, D. F., Erikson, J. M., Restrepo, J. F., Molina, E., Escalante, A. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

The specificity of ultrasound-detected bone erosions for rheumatoid arthritis
Conclusions The presence of US-detected erosions is not specific for RA. However, larger erosions in selected joints, especially 2nd and 5rd MCP, 5th MTP joints and distal ulna, were highly specific for and predictive of RA.
Source: Annals of the Rheumatic Diseases - April 2, 2015 Category: Rheumatology Authors: Zayat, A. S., Ellegaard, K., Conaghan, P. G., Terslev, L., Hensor, E. M. A., Freeston, J. E., Emery, P., Wakefield, R. J. Tags: Genetics, Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological Source Type: research

High incidence of disease recurrence after discontinuation of disease-modifying antirheumatic drug treatment in patients with psoriatic arthritis in remission
Conclusions This study shows that the chance to reach drug-free remission in PsA patients is low. Discontinuation of DMARD therapy cannot be recommended in patients with PsA.
Source: Annals of the Rheumatic Diseases - March 5, 2015 Category: Rheumatology Authors: Araujo, E. G., Finzel, S., Englbrecht, M., Schreiber, D. A., Faustini, F., Hueber, A., Nas, K., Rech, J., Schett, G. Tags: Immunology (including allergy), Radiology, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnost Source Type: research

Ultrasound definition of tendon damage in patients with rheumatoid arthritis. Results of a OMERACT consensus-based ultrasound score focussing on the diagnostic reliability
Conclusions Ultrasound is a reproducible tool for evaluating tendon damage in RA. This study strongly supports a new reliable ultrasound scoring system for tendon damage.
Source: Annals of the Rheumatic Diseases - October 5, 2014 Category: Rheumatology Authors: Bruyn, G. A. W., Hanova, P., Iagnocco, A., d'Agostino, M.-A., Moller, I., Terslev, L., Backhaus, M., Balint, P. V., Filippucci, E., Baudoin, P., van Vugt, R., Pineda, C., Wakefield, R., Garrido, J., Pecha, O., Naredo, E., Aydin, Bachta, Collado, Estrach, Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Performance of the new 2012 EULAR/ACR classification criteria for polymyalgia rheumatica: comparison with the previous criteria in a single-centre study
Conclusions The new EULAR/ACR criteria in new-onset PMR patients perform best in discriminating PMR from RA and other inflammatory articular diseases. Ultrasound further increases the specificity of the criteria.
Source: Annals of the Rheumatic Diseases - April 30, 2014 Category: Rheumatology Authors: Macchioni, P., Boiardi, L., Catanoso, M., Pazzola, G., Salvarani, C. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Ultrasound colour Doppler is associated with synovial pathology in biopsies from hand joints in rheumatoid arthritis patients: a cross-sectional study
Conclusions Colour Doppler activity is associated with the extent of inflammation present in the synovial biopsies from RA patients. However, synovial pathology was also seen in biopsies taken from Doppler negative sites.
Source: Annals of the Rheumatic Diseases - February 27, 2014 Category: Rheumatology Authors: Andersen, M., Ellegaard, K., Hebsgaard, J. B., Christensen, R., Torp-Pedersen, S., Kvist, P. H., Soe, N., Romer, J., Vendel, N., Bartels, E. M., Danneskiold-Samsoe, B., Bliddal, H. Tags: Immunology (including allergy), Pathology, Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Epid Source Type: research

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