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Limb and cardiovascular event risk in type 1 and 2 diabetic patients with peripheral artery disease
Conclusions: PAD patients with T1DM had a higher LE risk than those with T2DM, even after adjustment for glycemic control and pertinent risk factors, but CVE risk and all-cause mortality were equivocal. These data suggest a potential role for more intensive LE risk modification in PAD patients with T1DM, but further investigation is needed.PMID:37519117 | DOI:10.1024/0301-1526/a001086
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - July 31, 2023 Category: Surgery Authors: Daniel Sykora Christine Firth Marlene Girardo Andrew Tseng Paul Wennberg David Liedl Fadi Shamoun Source Type: research

Statin use improves survival of patients with known or suspected lower extremity artery disease on all ankle brachial index levels
Conclusions: According to our study, statins seem to improve overall and amputation free survival regardless of ABI level. Statin use was associated with lower mortality from cerebrovascular disease, overall mortality and in the propensity score matched patients with ABI<0.9 or >1.3 with cardiovascular mortality.PMID:36458408 | DOI:10.1024/0301-1526/a001041
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - December 2, 2022 Category: Surgery Authors: Mirjami Laivuori Fausto Biancari Juha Sinisalo Anders Alb äck Harri Hakovirta Reijo Sund Maarit Venermo Source Type: research

Effects of Statins on Early and Late Clinical Outcomes of Carotid Endarterectomy and the Rate of Post-Carotid Endarterectomy Restenosis
Statins have no effect on post-carotid endarterectomy (CEA) restenosis but are associated with decreased death rates in patients with diabetes trending to lower both death and stroke rates in diabetic patients with hypercholesterolemia.
Source: Journal of Vascular Surgery - November 22, 2015 Category: Surgery Authors: A.F. AbuRahma, M. Srivastava, P.A. Stone Tags: Abstract Source Type: research

Discussion
DR ERIC ENDEAN (Lexington, KY): The authors have presented a provocative study that has investigated the early and late effect of statins on patients undergoing carotid endarterectomy. The authors retrospectively evaluated 500 patients, 60% of whom were taking statins and 40% without statins. Interestingly, among the patients taking statins, they found a higher incidence of diabetes and, as would be expected, hypercholesterolemia. To the author's credit, there was a low incidence of stroke, MI, and death.
Source: Journal of the American College of Surgeons - March 21, 2015 Category: Surgery Tags: Southern surgical association article Source Type: research

Effect of Statins on Early and Late Clinical Outcomes of Carotid Endarterectomy and the Rate of Post-Carotid Endarterectomy Restenosis
A retrospective analysis of prospectively collected data on 500 consecutive CEAs followed routinely at 1, 6, and 12 months and every year thereafter. Statins significantly lowered death rates in diabetics and tended to lower both death and stroke rates in diabetics and patients with hypercholesterolemia. Statins had no effect on post-CEA restenosis.
Source: Journal of the American College of Surgeons - December 15, 2014 Category: Surgery Authors: Ali F. AbuRahma, Mohit Srivastava, Patrick A. Stone, Bryan K. Richmond, Zachary AbuRahma, Will Jackson, L Scott Dean, Albeir Y. Mousa Source Type: research

A Risk Prediction Model for Determining Appropriateness of CEA in Patients With Asymptomatic Carotid Artery Stenosis
A scoring system based on the probability of long-term survival can be used to determine patients most likely to benefit from carotid endarterectomy (CEA). There is considerable controversy about which patients with asymptomatic carotid stenosis, even high-grade asymptomatic carotid stenosis, are most likely to benefit from a prophylactic CEA. Indeed, there are those who believe that asymptomatic carotid stenosis may be best treated with carotid artery stenting and those who also contend that with modern medical therapy, asymptomatic carotid stenosis may be best treated with medical therapy alone. Although it seems intuit...
Source: Journal of Vascular Surgery - March 24, 2014 Category: Surgery Authors: M.F. Conrad, J. Kang, S. Mukhopadhyay Tags: Abstracts Source Type: research

Reduction in Early Stroke Risk in Carotid Stenosis With Transient Ischemic Attack Associated With Statin Treatment
In patients with acute symptomatic carotid stenosis, statin pretreatment is associated with reduced stroke risk. Carotid endarterectomy (CEA) in patients with associated symptoms is highly effective for secondary stroke prevention. Maximum benefit appears to be in those who undergo surgery ≤2 weeks of symptom onset; however, the safety of very early CEA has been questioned. Data from the Swedish Vascular Registry indicated an 11.5% stroke and death rate in patients undergoing CEA ≤48 hours of symptom onset. This is a fourfold increase in the odds of a poor outcome compared with those undergoing CEA from 3 to 7 days (S...
Source: Journal of Vascular Surgery - January 24, 2014 Category: Surgery Authors: Á. Merwick, G.W. Albers, E.M. Arsava Tags: Abstracts Source Type: research

Impact of Adding Aspirin to Beta-Blocker and Statin in High-Risk Patients Undergoing Major Vascular Surgery
In this study we evaluated the benefits of adding aspirin (A) to BB and S (ABBS), with/without angiotensin-converting enzyme inhibitor (ACE-I) on postoperative outcome in high-risk patients undergoing major vascular surgery.Methods: Analysis of consecutive patients undergoing elective vascular surgery at the University of Michigan Cardiovascular Center was performed. Univariate and multivariate analyses were done using cardiac risk index [Revised Cardiac Risk Index (RCRI), coronary artery disease (CAD), insulin-dependent diabetes mellitus (IDDM), cerebral vascular disease, renal dysfunction, congestive heart failure, and m...
Source: Annals of Vascular Surgery - March 25, 2013 Category: Surgery Authors: Wei C. Lau, James B. Froehlich, Elizabeth S. Jewell, Daniel G. Montgomery, Kristina M. Eng, Theresa A. Shields, Peter K. Henke, Kim A. Eagle Tags: Basic Data Underlying Clinical Decision-Making in Endovascular Therapy Source Type: research