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Atherosclerotic Disease: Pathogenesis and Approaches to Management
Med Clin North Am. 2023 Sep;107(5):793-805. doi: 10.1016/j.mcna.2023.04.004. Epub 2023 Jun 1.ABSTRACTAtherosclerotic disease, including stroke and myocardial infarction, is the leading cause of morbidity and mortality worldwide. Atherosclerotic plaque formation occurs in the setting of excess oxidative and hemodynamic stress and is perpetuated by smoking, poor diet, dyslipidemia, hypertension, and diabetes. Plaque may rupture, resulting in acute thrombotic events. Smoking cessation, lifestyle modification, risk factor optimization, and antithrombotic therapies are the mainstays of atherosclerotic disease management and are...
Source: The Medical Clinics of North America - August 4, 2023 Category: General Medicine Authors: Amanda M Morrison Alexander E Sullivan Aaron W Aday Source Type: research

Peripheral artery disease: Update on etiology, pathophysiology, diagnosis and treatment
Med Clin (Barc). 2023 Jul 28:S0025-7753(23)00361-5. doi: 10.1016/j.medcli.2023.06.005. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a condition related to atherosclerosis affecting >200 million people worldwide, and it increases cardiovascular morbidity (mainly from myocardial infarction and stroke) and mortality. Indeed, PAD patients are classified as patients at very high cardiovascular risk. The most common manifestation of PAD is intermittent claudication, which is associated with reduced mobility and leg pain. Nevertheless, asymptomatic PAD is the most frequent form of PAD worldwide; therefore, ...
Source: Medicina Clinica - July 30, 2023 Category: General Medicine Authors: Dar ío Mandaglio-Collados Francisco Mar ín Jos é Miguel Rivera-Caravaca Source Type: research

Environmental and lifestyle risk factors for early-onset dementia: a systematic review
CONCLUSIONS: The literature on environmental risk factors for EOD has been considerably growing in recent years. Overall, it supports an association between some environmental and lifestyle factors with disease risk. However, additional high-quality research is required to confirm these relations and its causal nature (www.actabiomedica.it).PMID:36533768 | DOI:10.23750/abm.v93i6.13279
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Bosi Marcella Malavolti Caterina Garuti Manuela Tondelli Cristina Marchesi Marco Vinceti Tommaso Filippini Source Type: research

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