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Melanocortin neurons: multiple routes to regulation of metabolism.
Abstract The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1, 2]. A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3-6]. In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the ener...
Source: Biochimica et Biophysica Acta - May 9, 2017 Category: Biochemistry Authors: Shen WJ, Yao T, Kong X, Williams KW, Liu T Tags: Biochim Biophys Acta Source Type: research

The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms
Biochimie. 2022 Oct 15:S0300-9084(22)00274-7. doi: 10.1016/j.biochi.2022.10.009. Online ahead of print.ABSTRACTThe global epidemic of diabetes has brought heavy pressure on public health. New effective anti-diabetes strategies are urgently needed. Trigonelline is the main component of fenugreek, which has been proved to have a good therapeutic effect on diabetes and diabetic complications. Trigonelline achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, a reduction in oxidative stress, and the improvement of glucose tolerance and insulin resistance. Besides, trigonelline ...
Source: Biochimie - October 18, 2022 Category: Biochemistry Authors: Youdan Liang Xiaolin Dai Yi Cao Xian Wang Jing Lu Long Xie Kai Liu Xiaofang Li Source Type: research