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Meta-Analysis on the Association between Brain-Derived Neurotrophic Factor Polymorphism rs6265 and Ischemic Stroke, Poststroke Depression
Ischemic stroke is a multifactorial neurologic injury that causes mortality and disability worldwide. Poststroke depression is the most important neuropsychiatric consequence of stroke. Brain-derived neurotrophic factor is a neurotrophin family member that plays key role in regulating neuron survival and differentiation. Studies found a polymorphism in brain-derived neurotrophic factor gene (rs6265) may associate with the ischemic stroke and poststroke depression risk. However, the results are inconclusive and inconsistent.
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2018 Category: Neurology Authors: Mei-Hua Bao, Shu-Zhen Zhu, Xin-Zheng Gao, Hong-Shuo Sun, Zhong-Ping Feng Source Type: research

Post-Stroke Depression in Jordan: Prevalence Correlates and Predictors
This study aimed to assess the prevalence of depression; its correlates, and predictors among patients with stroke in Jordan.
Source: Journal of Stroke and Cerebrovascular Diseases - December 27, 2017 Category: Neurology Authors: Shahnaz Mohammed Ayasrah, Muayyad M. Ahmad, Iman Amin Basheti Source Type: research

SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke
Background: The outcome of ischemic stroke depends on multiple factors and their function of each other. Studies have shown that Sirtuin1 (SIRT1) plays a chief role in the key procedure during ischemia/hypoxia by protecting against cellular stress and controlling the metabolic pathways. Aims: To explore the alterations in serum SIRT1 concentrations in acute ischemic stroke (AIS) patients and the relationship between SIRT1 and poststroke dementia, anxiety, and depression. Methods: One hundred and twenty four consecutive patients with clinically diagnosed AIS were recruited to participate in the study.
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2018 Category: Neurology Authors: Xue Liang, Yang Liu, Shiyu Jia, Xiaomin Xu, Meixue Dong, Youdong Wei Source Type: research

The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study
Background and purpose: The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome. Materials and methods: A prospective monocentric study including patients with a supratentorial ischemic stroke was conducted. A 3 Tesla brain MRI was performed at baseline. Mood and cognition were assessed using Hospital Anxiety and Depression scale (HAD), apathy inventory (AI), and Montreal Cognitive Assessment scale subscores, performed at 3 months poststroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2019 Category: Neurology Authors: Sharmila Sagnier, Fanny Munsch, Antoine Bigourdan, Sabrina Debruxelles, Mathilde Poli, Pauline Renou, St éphane Olindo, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon Source Type: research

A Retrospective Study to Identify Novel Factors Associated with Post-stroke Anxiety
Post-stroke anxiety (PSA) and depression (PSD) constitute critical complications of stroke.1 Evidence suggests that an estimated 18% to 25% of stroke patients develop significant and persistent PSA, which is associated with co-morbid psychological stress (eg, depression) and debilitating consequences (eg, diminished quality of life).1-3 PSD, female sex, and cognitive impairment are factors commonly reported to be significantly associated with PSA.4 While there is a growing body of literature about familiar factors associated with PSA, most studies were conducted in relatively racially and ethnically homogenous populations.
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2019 Category: Neurology Authors: Jennifer E. Sanner Beauchamp, Tahani Casameni Montiel, Chunyan Cai, Sudha Tallavajhula, Evelyn Hinojosa, Munachi N. Okpala, Farhaan S. Vahidy, Sean I. Savitz, Anjail Z. Sharrief Source Type: research

Assessment of the Progression of Poststroke Depression in Ischemic Stroke Patients Using the Patient Health Questionnaire-9
Poststroke depression (PSD) affects one-third of stroke patients and is linked with higher stroke morbidity, mortality, and recurrence. Current guidelines do not direct when to screen for PSD, and predictors of PSD are not well understood. We sought to understand progression of PSD symptoms early after ischemic stroke, identify predictors of PSD, and describe the use of antidepressants in PSD.
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2020 Category: Neurology Authors: Lauren E. Fournier, Jennifer E. Sanner Beauchamp, Xu Zhang, Esther Bonojo, Mary Love, Gabretta Cooksey, Evelyn Hinojosa, Munachi N. Okpala, Sean I. Savitz, Anjail Z. Sharrief Source Type: research

Factors influencing employment after minor stroke and NSTEMI
Aim: To study the effect of cognitive function, fatigue and emotional symptoms on employment after a minor ischemic stroke compared to non-ST-elevation myocardial infarction (NSTEMI).Material and methods: We included 217 patients with minor ischemic stroke and 133 NSTEMI patients employed at baseline aged 18 –70 years. Minor stroke was defined as modified Rankin scale (mRS) 0–2 at day seven or at discharge if before. Included NSTEMI patients had the same functional mRS. We applied a selection of cognitive tests and the patients completed questionnaires measuring symptoms of anxiety, depression and f atigue at follow up.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Åse Hagen Morsund, Hanne Ellekjær, Arne Gramstad, Magnus Tallaksen Reiestad, Rune Midgard, Sigrid Botne Sando, Egil Jonsbu, Halvor Næss Source Type: research

Factors Associated with Post-Stroke Depression in Chinese Stroke Survivors
To explore the relationship between participation self-efficacy, sociodemographic and clinical characteristics, and post-stroke depression in stroke survivors and provide insights into the development of rehabilitation programmes.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2021 Category: Neurology Authors: Janita P C Chau, Suzanne H S Lo, Jie Zhao, Kai Chow Choi, Simon K Y Lam, Laveeza Butt, David R Thompson Source Type: research

Psychological Burden in Stroke Survivors and Caregivers Dyads at the Rehabilitation Center of Kinshasa (Democratic Republic of Congo): A Cross-Sectional Study
This study aimed to assess the burden of depression and anxiety and covariates as well as its association with functional disability level among stroke survivors and caregivers dyads.
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2022 Category: Neurology Authors: Germain Manzekele Bin Kitoko, Bives Mutume Nzanzu Vivalya, Martial Mumbere Vagheni, Thierry Matonda Ma Nzuzi, Sam Mampunza Lusambulu, Gilbert Mananga Lelo, Magloire Nkosi Mpembi, Samuel Mampunza Ma Miezi Source Type: research

Associations Between Fatigue and Disability, Depression, Health-Related Hardiness and Quality of Life in People with Stroke
Stroke is a common cause of mortality and morbidity which affects approximately 17 million people globally each year. Common symptoms associated with stroke are physical disabilities, impaired cognitive functions, depression, and fatigue, all of which can significantly impact health-related quality of life (HRQoL). To date, no research has explored the inter-relationship among fatigue, disability, depression, health-related hardiness, and quality of life in stroke survivors.
Source: Journal of Stroke and Cerebrovascular Diseases - May 4, 2022 Category: Neurology Authors: David Sibbritt, Jessica Bayes, Wenbo Peng, Jane Maguire, Jon Adams Source Type: research

The Effects of Pretreatment versus De Novo Treatment with Selective Serotonin Reuptake Inhibitors on Short-term Outcome after Acute Ischemic Stroke
Selective serotonin reuptake inhibitors (SSRIs) administered in patients following acute ischemic stroke have shown to improve clinical recovery independently of changes in depression. Animal studies have demonstrated that sustained SSRI treatment is superior to short-term SSRI in evoking neurogenesis but how this benefit translates into humans remains to be answered. We hypothesized that in acute ischemic stroke patients, SSRI treatment started before the event leads to improved short-term outcomes compared to de novo SSRI treatment poststroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2015 Category: Neurology Authors: Timo Siepmann, Jessica Kepplinger, Charlotte Zerna, Ulrike Schatz, Ana Isabel Penzlin, Lars-Peder Pallesen, Ben Min-Woo Illigens, Kerstin Weidner, Heinz Reichmann, Volker Puetz, Ulf Bodechtel, Kristian Barlinn Source Type: research

The Effect of a Brief Intervention for Patients with Ischemic Stroke: A Randomized Controlled Trial
Depression and anxiety are common after stroke. There is inconclusive evidence of the benefit of psychotherapy for poststroke depression and anxiety. Here, we used a brief intervention, Neuro-Linguistic Programming (NLP) brief therapy plus health education, to evaluate the changes in patients with ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2015 Category: Neurology Authors: Yuehua Peng, Yun Lu, Weiquan Wei, Jincong Yu, Dongming Wang, Yang Xiao, Jinzhi Xu, Zengzhen Wang Source Type: research

Short-Term Trajectories of Depressive Symptoms in Stroke Survivors and Their Family Caregivers
We utilize group-based trajectory modeling (GBTM) to delineate depressive symptom trajectories among stroke survivor–caregiver dyads, to identify predictors of the delineated trajectories, and to assess the influence of time-varying covariates (stroke survivor depressive symptoms and functional disability, caregiver depressive symptoms, and foreign domestic worker [FDW] assistance) on the level of the depressive symptom trajectories.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2015 Category: Neurology Authors: Rahul Malhotra, Choy-Lye Chei, Edward Menon, Wai Leng Chow, Stella Quah, Angelique Chan, David Bruce Matchar Source Type: research

The Correlation between Depression, Balance, and Physical Functioning Post Stroke
The objective of this study was to examine the correlation between depression, balance, and self-reported physical performance in patients post stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 23, 2015 Category: Neurology Authors: Alia A. Alghwiri Source Type: research

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