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Oral contraceptives and stroke: Foes or friends
Front Neuroendocrinol. 2022 Jul 20:101016. doi: 10.1016/j.yfrne.2022.101016. Online ahead of print.ABSTRACTIncidents of strokes are increased in young women relative to young men, suggesting that oral contraceptive (OC) use is one of the causes of stroke among young women. Long-term exposures to the varying combinations of estrogen and progestogen found in OCs affect blood clotting, lipid and lipoprotein metabolism, endothelial function, and de novo synthesis of neurosteroids, especially brain-derived 17β-estradiol. The latter is essential for neuroprotection, memory, sexual differentiation, synaptic transmission, and beh...
Source: Frontiers in Neuroendocrinology - July 23, 2022 Category: Endocrinology Authors: Varun Reddy Megan Wurtz Shahil H Patel Micheline McCarthy Ami P Raval Source Type: research

Sickle Cell Trait Worsens Oxidative Stress, Abnormal Blood Rheology, and Vascular Dysfunction in Type 2 Diabetes
CONCLUSIONS Our results demonstrate severe biological abnormalities and marked vascular dysfunction in patients with both T2DM and SCT. SCT should be viewed as a risk factor for further cardiovascular disorders in individuals with T2DM.
Source: Diabetes Care - October 22, 2015 Category: Endocrinology Authors: Diaw, M.; Pialoux, V.; Martin, C.; Samb, A.; Diop, S.; Faes, C.; Mury, P.; Sall Diop, N.; Diop, S.-N.; Ranque, B.; Mbaye, M. N.; Key, N. S.; Connes, P. Tags: Pathophysiology/Complications Source Type: research