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Ischemic stroke, obesity, and the anti ‐inflammatory role of melatonin
AbstractObesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of ischemic stroke with concomitant obesity. Herein, we explore the proinflammatory events that occur during ischemic stroke and obesity, and we discuss the influence of obesity on the inflammatory response and cerebral damage outcomes in experimental models of brain ischemia. In addition, because melat...
Source: BioFactors - February 10, 2021 Category: Biochemistry Authors: Nuttapong Yawoot, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus Tags: REVIEW ARTICLE Source Type: research

Melanocortin neurons: multiple routes to regulation of metabolism.
Abstract The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1, 2]. A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3-6]. In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the ener...
Source: Biochimica et Biophysica Acta - May 9, 2017 Category: Biochemistry Authors: Shen WJ, Yao T, Kong X, Williams KW, Liu T Tags: Biochim Biophys Acta Source Type: research