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Adolescent weight gain confers long-term increased stroke risk: Weighty matters
Adult obesity has been consistently associated with risk of total, ischemic, and hemorrhagic stroke1–3; however, the degree to which change in weight and body mass index (BMI) during late childhood and adolescence affects adult risk of stroke has remained uncertain. Understanding this relationship is of particular importance given the rising obesity epidemic during childhood and adolescence.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Rexrode, K. M., Kimm, S. Y. S. Tags: All Pediatric, Adolescence, Cohort studies, Infarction, Intracerebral hemorrhage EDITORIALS Source Type: research

Achieving better detection of vascular risk factors for stroke prevention (P4.062)
Conclusions:The concept of vital station is a useful means of detecting vascular risk factor before appearance of noticeable symptoms and thus offers the benefit of being able to treat the disease much earlier which can lead to reduction of disease burden & economic losses and thus offers better health outcome.Disclosure: Dr. Mehndiratta has nothing to disclose. Dr. Wadhai has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mehndiratta, M. M., Wadhai, S. Tags: General Neurology: Vascular Neurology Source Type: research

Migraine and the Risk of Carotid Artery Dissection
Stroke incidence is increasing among patients aged 40 to 60 years —faster than in older age cohorts. Preliminary evidence suggests that ischemic stroke—not hemorrhage or subarachnoid hemorrhage—accounts for the increase. Many speculate that increasing incidences of classic vascular risk factors among young patients contribute to the increased incidence of st roke. Certainly, we are all aware of the obesity epidemic and continued prevalence of smoking, leading to premature atherosclerosis. Furthermore, equally relevant causes of stroke in the young include migraine, drug abuse, cervical arterial dissections, patent fo...
Source: JAMA Neurology - March 6, 2017 Category: Neurology Source Type: research

Obesity Increases Risk of Ischemic Stroke in Young Adults Brief Reports
Conclusions— These results indicate that obesity is a risk factor for young onset ischemic stroke and suggest that this association may be partially mediated through hypertension, diabetes mellitus, or other variables associated with these conditions.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Mitchell, A. B., Cole, J. W., McArdle, P. F., Cheng, Y.-C., Ryan, K. A., Sparks, M. J., Mitchell, B. D., Kittner, S. J. Tags: Risk Factors for Stroke Brief Reports Source Type: research

Comparison of major modifiable stroke risk factors associated with lacunar strokes in anterior and posterior circulation in multiethnic cohort (P7.143)
CONCLUSIONS: Hypertriglyceridemia may be associated with posterior circulation SVD. In the setting of the obesity epidemic, hypertriglyceridemia prevalence is increasing; therefore, we might expect a concomitant increase in the incidence of posterior circulation strokes.Disclosure: Dr. Bulic has nothing to disclose. Dr. Valle has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Bulic, S., Valle, N., Towfighi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Race, Ethnicity, and Stroke Source Type: research

Comment: Intracerebral hemorrhage incidence declines, but it is still highly fatal
Overall stroke mortality has declined over the last decades—a welcome trend.1 However, recent trends in intracerebral hemorrhage (ICH) incidence are not as clear. On the one hand, there has been increasingly good population control of hypertension; on the other hand, there is increasing use of anticoagulants and antithrombotic drugs, an epidemic of obesity and diabetes, and changing racial and ethnic demographics.
Source: Neurology - June 16, 2014 Category: Neurology Authors: Smith, E. E. Tags: Cohort studies, Incidence studies, Natural history studies (prognosis), Intracerebral hemorrhage ARTICLE Source Type: research

Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in Diet-Induced Obesity Basic Sciences
Conclusions— Endothelial dysfunction produced by a HFD occurs in a temporal manner and appears much earlier in cerebral arterioles than in carotid arteries. Genetic studies revealed that Nox2-derived superoxide plays a major role in endothelial dysfunction produced by a HFD. Such functional changes may serve to predispose blood vessels to reduced vasodilator responses and thus may contribute to alterations in cerebral blood flow associated with obesity.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Lynch, C. M., Kinzenbaw, D. A., Chen, X., Zhan, S., Mezzetti, E., Filosa, J., Ergul, A., Faulkner, J. L., Faraci, F. M., Didion, S. P. Tags: Animal models of human disease, Type 2 diabetes, Endothelium/vascular type/nitric oxide, Other Vascular biology Basic Sciences Source Type: research

Acute Stroke in Young Women Taking Phentermine (P01.249)
CONCLUSIONS: We present here two patients with mild underlying cerebrovascular risk factors who presented with acute stroke after taking diet pills containing phentermine. The public should be aware of the possible association between stroke and phentermine. More long-term outcomes research is necessary to understand the safety of phentermine-containing diet pills. Patients with cerebrovascular risk factors should be cautious about using Phentermine containing diet pills.Disclosure: Dr. Smit has nothing to disclose. Dr. Cutting has received personal compensation for activities with F1000. Dr. Conners has nothing to disclos...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Smit, L., Cutting, S., Conners, J., Lee, V., Song, S. Tags: P01 Cerebrovascular Disease I Source Type: research