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Atorvastatin Treatment and Carotid Plaque Morphology in First-ever Atherosclerotic Transient Ischemic Attack/Stroke: A Case–Control Study
A relationship between echolucency of carotid plaques and the consequent risk of ipsilateral ischemic stroke has been observed. An aggressive lipid-lowering therapy may increase the echogenicity of carotid plaque in patients with elevated low-density lipoprotein cholesterol levels. The aim of this study is to prospectively evaluate the long-term effect of high-dose atorvastatin on carotid plaque morphology in patients with first-ever transient ischemic attack or stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2014 Category: Neurology Authors: Pasquale Marchione, Claudio Vento, Manuela Morreale, Chiara Izzo, Andrea Maugeri, Federica Manuppella, Tommaso Romeo, Patrizia Giacomini Source Type: research

HMG-CoA Reductase Inhibitor (Statin) Prescribing for Ischemic Stroke Patients at Hospital Discharge (P2.306)
Conclusions: Our observations suggest that neurologists may be more likely to prescribe a statin at the time of discharge for whites in group 3 (diabetics age 40-75 with LDL 70-189 without ASCVD) when compared to their black counterparts. Further research is needed to determine if racial disparities exist in discharge statin prescribing for stroke survivors.Disclosure: Dr. Albright has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Sisson has nothing to disclose. Dr. Samai has nothing to disclose. Dr. Schluter has nothing to disclose. Dr. Martin-Schild has received personal compensation for activities with Genentech.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Albright, K., Vahidy, F., Moore, M., Samai, A., Schluter, L., Martin-Schild, S. Tags: Stroke Systems of Care Source Type: research

Prescription of Guideline-Based Medical Therapies at Discharge After Carotid Artery Stenting and Endarterectomy: An NCDR Analysis Clinical Sciences
Conclusions— US antiplatelet agent and statin discharge prescription rates were suboptimal after both CAS and CEA and varied by revascularization modality, operating physician specialty, and hospital characteristics. Improved and more uniform utilization after these procedures will be critical to the success of comprehensive stroke risk reduction efforts.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Aronow, H. D., Kennedy, K. F., Wayangankar, S. A., Katzen, B. T., Schneider, P. A., Abou-Chebl, A., Rosenfield, K. A. Tags: Secondary Prevention, Cardiovascular Surgery, Stent, Cerebrovascular Disease/Stroke, Peripheral Vascular Disease Clinical Sciences Source Type: research

The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study: Rationale and Trial Protocol
The preventive effect of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study aims to determine the effect of pravastatin on carotid IMT in Japanese patients with hyperlipidemia who developed noncardioembolic ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 20, 2016 Category: Neurology Authors: Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Naohisa Hosomi, Hideki Origasa, Kazuo Kitagawa, Shinichiro Uchiyama, Masatoshi Koga, Masayasu Matsumoto, J-STARS Investigators Source Type: research

Exercise for stroke prevention: The neglected prescription
For over a decade, clinicians have used multimodal pharmacologic therapy for optimal stroke prevention based in part on promising results from clinical trials demonstrating the value of blood pressure and cholesterol lowering for secondary stroke prevention. Patients are typically treated with a cocktail of medications, including antithrombotic agents, antihypertensives, and statins.1
Source: Neurology - January 22, 2017 Category: Neurology Authors: Chaturvedi, S., Nahab, F. Tags: Stroke prevention, Infarction EDITORIALS Source Type: research

The effect of statin use in acute ischemic stroke patients treated with thrombolytic therapy
This study investigated the effects of statins for the acute ischemic stroke patients after thrombolysis on the stroke outcome considering statin intensity and time window.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Jong-Moo Park, Tae Kyoung Kim, Eui Sung Jung, Kyusik Kang, Woung-Woo Lee, Jungju Lee, Ohyun Kwon, Byung-Kun Kim Source Type: research

Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke Original Articles
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research

Very Low Cholesterol May Increase Stroke Risk
Researchers found that very low LDL, or “ bad ” cholesterol, and very low triglycerides are associated with an increased risk for hemorrhagic stroke.
Source: NYT Health - April 10, 2019 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Cholesterol Stroke Triglycerides Blood Pressure Hemorrhagic Stroke Hypertension Source Type: news

Association of CYP3A4*1G and CYP3A5*3 With the 1-year Outcome of Acute Ischemic Stroke in the Han Chinese Population
Background and purpose: Previous studies have shown that common variants within CYP3A4 and CYP3A5 are associated with statin pharmacokinetics and the risk of cardiovascular disease. However, the association of variants in CYP3A4 and CYP3A5 with the prognosis of ischemic stroke remains undetermined. Therefore, we investigated this herein. Methods: Four hundred thirty-three consecutive patients with acute ischemic stroke were recruited. The outcome at the 1-year follow-up was assessed using the modified Rankin Scale (mRS).
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2019 Category: Neurology Authors: Shuo Li, Chang-he Shi, Xin-jing Liu, Yu-sheng Li, Shao-hua Li, Bo Song, Yu-ming Xu Source Type: research

When ‘Bad’ Cholesterol Gets Too Low, Stroke Risk May Rise
LDL levels below 70 were tied to an increased risk of hemorrhagic stroke.
Source: NYT Health - July 8, 2019 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Cholesterol Stroke Hemorrhagic Stroke Heart Source Type: news

Statins for the Prevention of Post-Stroke Seizure and Epilepsy Development: A Systematic Review and Meta-Analysis
Cerebrovascular disease is the leading cause of seizures and incident epilepsy of known etiology in older adults. Statins have increasingly garnered attention as a potential preventive strategy due to their pleiotropic effects beyond lipid-lowering, which may include neuroprotective and anti-epileptogenic properties. We aim to assess the evidence on statin use for prevention of post-stroke early-onset seizures and post-stroke epilepsy.
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2021 Category: Neurology Authors: Emily K. Acton, Ossama Khazaal, Allison W. Willis, Michael A. Gelfand, Sean Hennessy, Magdy H. Selim, Scott E. Kasner Source Type: research

Statin Therapy Should be Discontinued in Patients With Intracerebral Hemorrhage Controversies in Stroke
Source: Stroke - June 24, 2013 Category: Neurology Authors: Goldstein, L. B. Tags: Secondary prevention, Acute Cerebral Hemorrhage Controversies in Stroke Source Type: research

Effects of Early Exercise Engagement on Vascular Risk in Patients with Transient Ischemic Attack and Nondisabling Stroke
The objective of this study was to conduct a randomized, parallel-group clinical trial assessed the efficacy of a health-enhancing physical activity program (exercise and education) on vascular risk factors and aerobic fitness in patients who have experienced a transient ischemic attack (TIA) or nondisabling stroke. Sixty patients (69 ± 11 years) completed a baseline (BL) vascular risk stratification and aerobic fitness examination (cycle test) within 2 weeks of symptom onset. Subjects were then randomized to either an 8-week, twice weekly exercise program or to a usual-care control (CON) group. Postintervention (PI) ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2013 Category: Neurology Authors: James Faulkner, Danielle Lambrick, Brandon Woolley, Lee Stoner, Lai-kin Wong, Gerard McGonigal Tags: Original Articles Source Type: research

Demographic and Clinical Predictors of Leptomeningeal Collaterals in Stroke Patients
Background: Leptomeningeal collaterals improve outcome after stroke, including reduction of hemorrhagic complications after thrombolytic or endovascular therapy, smaller infarct size, and reduction in symptoms at follow-up evaluation. The purpose of this study was to determine the demographic and clinical variables that are associated with a greater degree of cerebral collaterals.Methods: Clinical data of patients presenting with M1 occlusions of the middle cerebral artery (MCA) and associated computed tomography angiography studies after admission from 3 separate institutions were retrospectively compiled (n = 82). Occl...
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Nitin Malik, Qinghua Hou, Achala Vagal, James Patrie, Wenjun Xin, Patrik Michel, Ashraf Eskandari, Tudor Jovin, Max Wintermark Tags: Original Articles Source Type: research

Strong Reduction of Low-Density Lipoprotein Receptor/Apolipoprotein E Expressions by Telmisartan in Cerebral Cortex and Hippocampus of Stroke Resistant Spontaneously Hypertensive Rats
Conclusions: These findings suggest that a long-term treatment with telmisartan directly improved neuronal lipid metabolism in the cerebral cortex and hippocampus of SHR-SR, mainly improving LDL-R and ApoE metabolism (SHR/Low) with a small additive benefit by BP lowering (SHR/High), which could provide a preventative approach in patients with hypertension at risk of Alzheimer disease.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2014 Category: Neurology Authors: Yun Zhai, Toru Yamashita, Tomoko Kurata, Yusuke Fukui, Kota Sato, Syoichiro Kono, Wentao Liu, Yoshio Omote, Nozomi Hishikawa, Kentaro Deguchi, Koji Abe Tags: Original Articles Source Type: research