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Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
CONCLUSION: Neither egg nor cholesterol intakes were associated with stroke risk in this cohort, regardless of apoE phenotype.This trial was registered at www.clinicaltrials.gov as NCT03221127. PMID: 31095282 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 15, 2019 Category: Nutrition Authors: Abdollahi AM, Virtanen HEK, Voutilainen S, Kurl S, Tuomainen TP, Salonen JT, Virtanen JK Tags: Am J Clin Nutr Source Type: research

The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK).
Conclusions: Higher plasma PAr was independently associated with increased risk of incident stroke in all participants and across all subgroups stratified by conventional risk predictors. Our novel findings point to and expand the range of inflammation and immune activation processes that may be relevant for the pathogenesis and prevention of stroke. This trial was registered at clinicaltrials.gov as NCT03013725. PMID: 29381795 [PubMed - in process]
Source: The American Journal of Clinical Nutrition - January 1, 2018 Category: Nutrition Authors: Zuo H, Tell GS, Ueland PM, Nygård O, Vollset SE, Midttun Ø, Meyer K, Ulvik A Tags: Am J Clin Nutr Source Type: research

Intake of trans fat and all-cause mortality in the Reasons for Geographical and Racial Differences in Stroke (REGARDS) cohort.
CONCLUSION: Higher trans fat intake is associated with an increased risk of all-cause mortality. PMID: 23553155 [PubMed - in process]
Source: The American Journal of Clinical Nutrition - May 1, 2013 Category: Nutrition Authors: Kiage JN, Merrill PD, Robinson CJ, Cao Y, Malik TA, Hundley BC, Lao P, Judd SE, Cushman M, Howard VJ, Kabagambe EK Tags: Am J Clin Nutr Source Type: research

Dietary cholesterol and egg intake in relation to incident cardiovascular disease and all-cause and cause-specific mortality in postmenopausal women.
CONCLUSIONS: Both higher dietary cholesterol intake and higher egg consumption appeared to be associated with modestly elevated risk of incident CVD and all-cause mortality in US postmenopausal women. PMID: 33330926 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - December 17, 2020 Category: Nutrition Authors: Chen GC, Chen LH, Mossavar-Rahmani Y, Kamensky V, Shadyab AH, Haring B, Wild RA, Silver B, Kuller LH, Sun Y, Saquib N, Howard B, Snetselaar LG, Neuhouser ML, Allison MA, Van Horn L, Manson JE, Wassertheil-Smoller S, Qi Q Tags: Am J Clin Nutr Source Type: research

Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis.
CONCLUSION: Reviewed studies were heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of dietary cholesterol on CVD risk. Carefully adjusted and well-conducted cohort studies would be useful to identify the relative effects of dietary cholesterol on CVD risk. PMID: 26109578 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - June 24, 2015 Category: Nutrition Authors: Berger S, Raman G, Vishwanathan R, Jacques PF, Johnson EJ Tags: Am J Clin Nutr Source Type: research

WHO guidelines for a healthy diet and mortality from cardiovascular disease in European and American elderly: the CHANCES project.
CONCLUSION: Overall, greater adherence to the WHO dietary guidelines was not significantly associated with CVD mortality, but the results varied across regions. Clear inverse associations were observed in elderly populations in southern Europe and the United States. PMID: 26354545 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - September 9, 2015 Category: Nutrition Authors: Jankovic N, Geelen A, Streppel MT, de Groot LC, Kiefte-de Jong JC, Orfanos P, Bamia C, Trichopoulou A, Boffetta P, Bobak M, Pikhart H, Kee F, O'Doherty MG, Buckland G, Woodside J, Franco OH, Ikram MA, Struijk EA, Pajak A, Malyutina S, Kubinova R, Wennberg Tags: Am J Clin Nutr Source Type: research

Low-fat dietary pattern and cardiovascular disease: results from the Women's Health Initiative randomized controlled trial.
Conclusions: CVD risk in postmenopausal women appears to be sensitive to a change to a low-fat dietary pattern and, among healthy women, includes both CHD benefit and stroke risk. This trial was registered at clinicaltrials.gov as NCT00000611. PMID: 28515068 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 17, 2017 Category: Nutrition Authors: Prentice RL, Aragaki AK, Van Horn L, Thomson CA, Beresford SA, Robinson J, Snetselaar L, Anderson GL, Manson JE, Allison MA, Rossouw JE, Howard BV Tags: Am J Clin Nutr Source Type: research

Different associations between HDL cholesterol and cardiovascular diseases in people with diabetes mellitus and people without diabetes mellitus: a prospective community-based study
CONCLUSIONS: High HDL-cholesterol concentrations were paradoxically associated with high risk of composite CVD outcomes in individuals with or without DM. However, low HDL-cholesterol concentrations failed to predict future CVD risk in individuals with DM.PMID:34019626 | DOI:10.1093/ajcn/nqab163
Source: The American Journal of Clinical Nutrition - May 21, 2021 Category: Nutrition Authors: Zhijun Wu Zhe Huang Alice H Lichtenstein Cheng Jin Shuohua Chen Shouling Wu Xiang Gao Source Type: research

Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet.
Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD. PMID: 28814398 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - August 16, 2017 Category: Nutrition Authors: Toledo E, Wang DD, Ruiz-Canela López M, Clish CB, Razquin C, Zheng Y, Guasch-Ferré M, Hruby A, Corella D, Gómez-Gracia E, Fiol M, Estruch R, Ros E, Lapetra J, Fito M, Aros F, Serra-Majem L, Liang L, Salas-Salvadó J, Hu FB, Martínez-González MA Tags: Am J Clin Nutr Source Type: research

Avocado consumption and risk factors for heart disease: a systematic review and meta-analysis.
Conclusions: Avocado intake resulted in no difference in serum TC, LDL-cholesterol, and TG concentrations, but it did increase serum HDL-cholesterol concentrations, with significant heterogeneity. The association between avocado intake and CVD risk should be confirmed by well-conducted prospective observational studies or long-term trials. PMID: 29635493 [PubMed - in process]
Source: The American Journal of Clinical Nutrition - April 1, 2018 Category: Nutrition Authors: Mahmassani HA, Avendano EE, Raman G, Johnson EJ Tags: Am J Clin Nutr Source Type: research

A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative.
CONCLUSIONS: These results lay the foundation for the combination of many genome-wide gene-diet interactions for diet response prediction while highlighting the need for further research and larger samples in order to achieve robust biomarkers for use in personalized nutrition. PMID: 32135010 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - March 4, 2020 Category: Nutrition Authors: Westerman K, Liu Q, Liu S, Parnell LD, Sebastiani P, Jacques P, DeMeo DL, Ordovás JM Tags: Am J Clin Nutr Source Type: research