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Trends in low-density lipoprotein cholesterol goal achievement and changes in lipid-lowering therapy after incident atherosclerotic cardiovascular disease: Danish cohort study
CONCLUSION: LDL-C goal achievement within the first 2 years after inclusion increased from 40.5% in 2010 to 50.6% in 2015. LLT initiation within the first year after inclusion increased, especially for intensive LLT, although only one third initiated intensive LLT in 2015. Despite trends show improvements in LDL-C goal achievement, 49.4% of individuals at very high risk of a CV event did not achieve the LDL-C goal within 2 years after ASCVD hospitalization.PMID:37256879 | PMC:PMC10231813 | DOI:10.1371/journal.pone.0286376
Source: Atherosclerosis - May 31, 2023 Category: Cardiology Authors: Annette Kj ær Ersbøll Marie Skov Kristensen Mads Nybo Simone M øller Hede Kristian Handberg Mikkelsen Gunnar Gislason Mogens Lytken Larsen Anders Green Source Type: research

Dual elevated remnant cholesterol and C-reactive protein in myocardial infarction, atherosclerotic cardiovascular disease, and mortality
CONCLUSIONS: Dual elevated remnant cholesterol and C-reactive protein confers the highest risk of myocardial infarction, ASCVD, and all-cause mortality, that is, compared to either of these two factors individually.PMID:37217436 | DOI:10.1016/j.atherosclerosis.2023.05.010
Source: Atherosclerosis - May 22, 2023 Category: Cardiology Authors: Takahito Doi Anne Langsted B ørge G Nordestgaard Source Type: research

Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry
CONCLUSIONS: LDL-C appears to be almost exclusively associated with ASCVD events over ≈5 years of follow-up in middle-aged individuals with versus without evidence of coronary atherosclerosis. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.PMID:36621817 | DOI:10.1161/CIRCULATIONAHA.122.061010
Source: Circulation - January 9, 2023 Category: Cardiology Authors: Martin B ødtker Mortensen Omar Dzaye Hans Erik B øtker Jesper M øller Jensen Michael Maeng Jacob Fog Bentzen Helle Kanstrup Henrik Toft S ørensen Jonathon Leipsic Ron Blankstein Khurram Nasir Michael J Blaha Bjarne Linde N ørgaard Source Type: research

Association of Coronary Plaque With Low-Density Lipoprotein Cholesterol Levels and Rates of Cardiovascular Disease Events Among Symptomatic Adults
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that in symptomatic patients with severely elevated LDL-C levels of at least 190 mg/dL who are universally considered to be at high risk by guidelines, absence of calcified and noncalcified plaque on coronary computed tomographic angiography was associated with low risk for ASCVD events. These results further suggest that atherosclerosis burden, including CAC, can be used to individualize treatment intensity in patients with severely elevated LDL-C levels.PMID:35147685 | DOI:10.1001/jamanetworkopen.2021.48139
Source: Atherosclerosis - February 11, 2022 Category: Cardiology Authors: Martin B ødtker Mortensen Miguel Ca ínzos-Achirica Flemming Hald Steffensen Hans Erik B øtker Jesper M øller Jensen Niels Peter R ønnow Sand Michael Maeng Jens Meldgaard Bruun Michael J Blaha Henrik Toft S ørensen Manan Pareek Khurram Nasir Bjarne L Source Type: research

Temporal Changes in Secondary Prevention and Cardiovascular Outcomes after Revascularization for Peripheral Arterial Disease in Denmark: A Nationwide Cohort Study.
Conclusions: Medical prevention of adverse events has increased considerably over time in patients that underwent revascularization for symptomatic PAD. This increase was accompanied by reductions in all adverse outcomes, except major amputations. PMID: 33300375 [PubMed - as supplied by publisher]
Source: Circulation - December 10, 2020 Category: Cardiology Authors: Søgaard M, Nielsen PB, Skjøth F, Eldrup N, Larsen TB Tags: Circulation Source Type: research