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Mechanical thrombectomy with the Solitaire stent: is there a learning curve in achieving rapid recanalization times?
Conclusions There is a learning curve involved in the efficient use of the Solitaire stent in endovascular acute stroke therapy. Along with improvements in patient transfer to angiography and improved efficiency with intracranial access, mastering this device contributed significantly towards reducing recanalization times.
Source: Journal of NeuroInterventional Surgery - October 7, 2014 Category: Neurosurgery Authors: Eesa, M., Burns, P. A., Almekhlafi, M. A., Menon, B. K., Wong, J. H., Mitha, A., Morrish, W., Demchuk, A. M., Goyal, M. Tags: Ischemic stroke Source Type: research

Effects of vascular comorbidity in parkinson's disease
Vascular disease and risk factors are common in Parkinson's disease (PD) and may influence phenotype. Statin therapy may thus be indicated. 1759 recently diagnosed PD cases from a multicentre prospective study underwent a Montreal Cognitive Assessment and the Unified PD Rating Scale part 3 (UPDRS 3). History of vascular events, risk factors and statin usage was recorded. QRISK2 quantified cardiovascular risk. Mean age was 67.5 (SD 9.3), disease duration 1.3 (SD 0.9) years, 65.2% male. 4.7% had prior stroke/TIA, 12.5% cardiac disease, 30.4% hypertension, 27.3% high cholesterol, 20.7% obesity, 7.2% diabetes and 4.6% smokers....
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Swallow, D. M. A., Malek, N., Grosset, K. A., Lawton, M. A., Bajaj, N. P., Barker, R. A., Ben-Shlomo, Y., Burn, D. J., Morris, H. R., Williams, N., Wood, N. W., Grosset, D. G., on behalf of the PRoBaND collaborators Tags: Drugs: CNS (not psychiatric), Parkinson's disease, Hypertension, Memory disorders (psychiatry) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Grey matter and csf amyloid in early non-demented parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation in parkinson's disease (icicle-pd) study
Conclusion We report a significant correlation between reduced GM volume and lower Aβ1–40 and Aβ1–42 levels in patients with newly diagnosed PDND. These data suggest that even in early PD, CSF markers may be associated with measures of brain atrophy. Although neither GM loss nor Aβ1–40 or Aβ1–42 levels correlated with cognitive performance, we postulate that this reflects the very early nature of the neurodegenerative process in this cohort.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Duncan, G. W., Yarnall, A. J., Firbank, M. J., Barker, R. A., O'Brien, J. T., Burn, D. J. Tags: Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Grey matter correlations of cognitive impairment in early parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation-parkinson's disease (icicle-pd) study
Conclusion GM loss is not present in newly diagnosed PD, either in patients with PD–MCI or PD–NC. These data are consistent with neuropathological studies suggesting that GM loss occurs with disease progression and is not prominent in early PD where the neurodegenerative process is more limited.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Duncan, G. W., Firbank, M. J., Yarnall, A. J., Barker, R. A., O'Brien, J. T., Burn, D. J. Tags: Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Octo Source Type: research

Endoscopic supraorbital eyebrow approach for the surgical treatment of extraaxialand intraaxial tumors.
Conclusions The endoscopic supraorbital eyebrow approach is a safe and effective minimally invasive approach to remove extra- and intraaxial anterior skull base, parasellar, and frontal lesions, promoting a rapid recovery and short hospital stay. The location of the eyebrow incision demands a meticulous cosmetic closure, but, with proper technique, cosmetic results are excellent. PMID: 25270140 [PubMed - in process]
Source: Neurosurgical Focus - October 1, 2014 Category: Neurosurgery Authors: Gazzeri R, Nishiyama Y, Ph D, Teo C Tags: Neurosurg Focus Source Type: research

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study
Conclusions Reductions in cortical FDG metabolism were present in newly diagnosed PD, and correlated with performance on neuropsychological tests. A reduced baseline parietal metabolism is associated with risk of cognitive decline and may represent a potential biomarker for this state and the development of PD dementia.
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 16, 2017 Category: Neurosurgery Authors: Firbank, M. J., Yarnall, A. J., Lawson, R. A., Duncan, G. W., Khoo, T. K., Petrides, G. S., O'Brien, J. T., Barker, R. A., Maxwell, R. J., Brooks, D. J., Burn, D. J. Tags: Open access, Brain stem / cerebellum, Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) Movement disorders Source Type: research

188 Structural differences in access to neurological healthcare in Northern Ireland: a neurodisparity index
Disparities in management of neurological patients should be minimal in a universal healthcare system. Northern Ireland has one neuroscience centre but no neurology centres. We have devised an easily- applied neurodisparity index (NDI) to measure population equity of neurological healthcare. NDI=number of patients managed per 105 population per Trust/number of patients managed per 105 population of the tertiary centre Trust. NDIs <0.75 and >1.25 were arbitrarily designated as neurodisparities. NDIs were calculated between 2013–2016 for intravenous thrombolysis (eight centres) or mechanical thrombectomy (one cen...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: McCarron, M., Burns, P., Forbes, R., McCarron, L., Mcverry, F. Tags: Poster Presentations Source Type: research