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Renal denervation for resistant hypertension
CONCLUSIONS: In patients with resistant hypertension, there is low-certainty evidence that renal denervation does not improve major cardiovascular outomes and renal function. Conversely, moderate-certainty evidence exists that it may improve 24h ABPM and diastolic office-measured BP. Future trials measuring patient-centred instead of surrogate outcomes, with longer follow-up periods, larger sample size and more standardised procedural methods are necessary to clarify the utility of this procedure in this population.PMID:34806762 | DOI:10.1002/14651858.CD011499.pub3
Source: Cochrane Database of Systematic Reviews - November 22, 2021 Category: General Medicine Authors: Anna Pisano Luigi Francesco Iannone Antonio Leo Emilio Russo Giuseppe Coppolino Davide Bolignano Source Type: research

Renal denervation for resistant hypertension.
CONCLUSIONS: In patients with resistant hypertension, there is low quality evidence that renal denervation does not change major cardiovascular events, and renal function. There was moderate quality evidence that it does not change blood pressure and and low quality evidence that it caused an increaseof bradycardia episodes. Future trials measuring patient-centred instead of surrogate outcomes, with longer follow-up periods, larger sample size and more standardized procedural methods are necessary to clarify the utility of this procedure in this population. PMID: 28220472 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 20, 2017 Category: Journals (General) Authors: Coppolino G, Pisano A, Rivoli L, Bolignano D Tags: Cochrane Database Syst Rev Source Type: research

Functional changes of neural circuits in stroke patients with dysphagia: a meta ‐analysis
ConclusionsThe hyperactivity of precentral gyrus is crucial in stroke patients with dysphagia and may be associated with the severity of stroke. Besides the motor areas, the Default‐Mode Network regions (DMN) and Affective Network regions (AN) circuits are also involved in dysphagia after stroke.This article is protected by copyright. All rights reserved
Source: Journal of Evidence-Based Medicine - October 31, 2016 Category: Journals (General) Authors: Lu Liu, Yuan Xiao, Wenjing Zhang, Li Yao, Xin Gao, Shah Chandan, Su Lui Tags: ARTICLE Source Type: research

Food addiction: Definition, measurement and limits of the concept, associated factors, therapeutic and clinical implications.
Abstract Addictions, which are characterized by the inability to control a behavior despite existence of physical or psychological consequences, have biological, psychological and social determinants. Although the possibility of developing an addiction to some psychoactive substances (e.g. alcohol, tobacco, cannabis) and to gambling (i.e., gambling disorder) is now well demonstrated, the possibility to develop a non-drug addiction (i.e., behavioral addiction) to certain behaviors which provide pleasure (e.g. eating, having sex, buying things) is still in debate. The concept of food addiction, which refers to peopl...
Source: Presse Medicale - May 18, 2016 Category: Journals (General) Authors: Cathelain S, Brunault P, Ballon N, Réveillère C, Courtois R Tags: Presse Med Source Type: research

Myocardial injury in a 41-year-old male treated with methylphenidate: a case report
Conclusions: When interpreting troponin results it is important to take into account the context of the patient's clinical presentation, including the possibility of adverse drug reactions. The adverse drug reaction could include a combination of vasospasm and/or increased oxygen demand due to tachycardia. This case should be borne in mind before a diagnosis of myocardial infarction is given, or a decision to perform invasive coronary angiography is made in patients that use methylphenidate or related substances. Cardiac magnetic resonance imaging could be of diagnostic value in such cases.
Source: BioMed Central - July 29, 2014 Category: Journals (General) Authors: Lisa Drange HoleJan Schjøtt Source Type: research