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Specialty: Research
Condition: Heart Disease
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Total 175 results found since Jan 2013.
Study Shows Value of Calcium Scan in Predicting Heart Attack and Stroke Among Those Considered at Either Low or High Risk - 12/23/13
A new study shows that coronary artery calcium (CAC) screening, an assessment tool that is not currently recommended for people considered at low risk, should play a more prominent role in helping determine a person’s risk for heart attack and heart disease-related death, as well as the need for angioplasty or bypass surgery.
Source: Johns Hopkins Medicine News - December 23, 2013 Category: Research Source Type: news
Unusual Suspect: Johns Hopkins Scientists Find ‘Second Fiddle’ Protein has Leading Role in Type 2 Diabetes - 4/10/13
A team of researchers at the Johns Hopkins Children’s Center has found that a protein long believed to have a minor role in type 2 diabetes is, in fact, a central player in the development of the condition that affects nearly 26 million people in the United States alone and counts as one of the leading causes of heart disease, stroke and kidney, eye and nerve damage.
Source: Johns Hopkins Medicine News - April 10, 2013 Category: Research Source Type: news
A Novel Strategy To Regulate Cholesterol Biosynthesis With MicroRNAs
A Method of Reducing Cholesterol Biosynthesis with Specific MicroRNAsDescription of Invention:
This technology is directed to the discovery of specific microRNAs that target and downregulate enzymes within the cholesterol biosynthetic pathway and is currently being tested in vivo.Briefly, microRNAs regulate the translation of messenger RNAs (mRNAs) into protein. The inventors have discovered a set of specific microRNAs that downregulate the expression of multiple enzymes in the cholesterol biosynthetic pathway. Importantly, this technology may provide the benefits of cholesterol lowering therapies to patients that are not ...
Source: NIH OTT Licensing Opportunities - April 20, 2010 Category: Research Authors: ott-admin Source Type: research
A Method of Reducing Cholesterol Biosynthesis with Specific MicroRNAs
This technology is directed to the discovery of specific microRNAs that target and downregulate enzymes within the cholesterol biosynthetic pathway and is currently being tested in vivo.Briefly, microRNAs regulate the translation of messenger RNAs (mRNAs) into protein. The inventors have discovered a set of specific microRNAs that downregulate the expression of multiple enzymes in the cholesterol biosynthetic pathway. Importantly, this technology may provide the benefits of cholesterol lowering therapies to patients that are not suited for statin-based treatments. Statins block the cholesterol biosynthetic pathway at a sin...
Source: NIH OTT Licensing Opportunities - April 20, 2010 Category: Research Authors: ott-admin Source Type: research
Therapeutic Peptide Treatment for Dyslipidemic and Vascular Disorders
This invention is directed to use of certain peptide analogs comprising multiple amphipathic helical domains that are able to promote cellular lipid efflux and stimulate lipoprotein lipase activity. As a result, administration of invention peptides lead to reduced incidences of hypertriglyceridemia without inducing toxicity. Existing peptides that stimulate efflux of lipids from cells exhibit unacceptably high toxicity. Invention peptides are superior to existing peptides and can also be used to treat or prevent a vast range of vascular diseases, and their dyslipidemic precursors. Exemplary vascular diseases and conditions...
Source: NIH OTT Licensing Opportunities - July 29, 2009 Category: Research Authors: ajoyprabhu3 Source Type: research
Methods of Preventing Tissue Ischemia
Nitric oxide (NO) plays an important role as a major intrinsic vasodilator, and increases blood flow to tissues and organs. Disruption of this process leads to peripheral vascular disease, ischemic heart disease, stroke, diabetes, and many more significant diseases.
Researchers at the NIH have discovered that the matrix protein thrombospondin-1 blocks the beneficial effects of NO, and prevents it from dilating blood vessels and increasing blood flow to organs and tissues. Additionally, the inventors discovered that this regulation requires interaction with thrombospondin-1's cell receptor CD47. Murine studies revealed that...
Source: NIH OTT Licensing Opportunities - August 1, 2008 Category: Research Authors: admin Source Type: research
Genes For Niemann-Pick Type C Disease
Niemann-Pick disease is a class of inherited lipid storage diseases. Niemann-Pick Type C disease is an autosomal recessive neurovisceral lipid storage disorder which leads to systemic and neurological abnormalities including ataxia, seizures, and loss of speech. Patients with the disease typically die as children. The biochemical hallmark of Niemann-Pick Type C cells is the abnormal accumulation of unesterified cholesterol in lysosomes, which results in the delayed homeostatic regulation of both uptake and esterification of low density lipoprotein (LDL) cholesterol. Niemann-Pick Type C is characterized by phenotypic variab...
Source: NIH OTT Licensing Opportunities - February 1, 2006 Category: Research Authors: ajoyprabhu3 Source Type: research
Anti-Marinobufagenin Antibodies and Methods for Diagnosis and Treatment of Cardiovascular Disease
Hypertension is a condition characterized by persistent high arterial blood pressure. Hypertension may have no known cause (essential or idiopathic hypertension) or may be associated with other primary diseases (secondary hypertension), and is considered a risk factor for the development of heart disease, peripheral vascular disease, stroke, and kidney disease. Preeclampsia is a similar condition that occurs in 5-10% of all pregnancies (most common in first time pregnancies) and is characterized by high blood pressure, edema, and protein in the urine. Complications of preeclampsia include eclampsia (convulsions and coma) a...
Source: NIH OTT Licensing Opportunities - August 1, 2005 Category: Research Authors: ajoyprabhu3 Source Type: research
