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Understanding Digoxin
 Most of us have heard of, or encountered a patient taking Digoxin at some point in our carreers. But, do we understand what it is and how it affects our patient?    Digoxin (Lanoxin), is a Cardiac Glycoside, derived from the foxglove plant, Digitalis. This medication is often seen in the pre-hospital setting, used for the treatment of:    Heart Failure (HF) with reduced Systolic Function   Atrial Fibrillation (AF) and Atrial Flutter (A-flutter) associated with Rapid Ventricular Response (RVR)   Cardiomyopathies   Often combined with Calcium and Beta Channel Blockers, Angiot...
Source: EMS 12-Lead - January 10, 2014 Category: Cardiology Authors: Ivan Rios Tags: Atrial Fibrillation Bidirectional Ventricular Tachycardia Digoxin Digoxin toxicity Heart Failure Source Type: research

Racial Differences in Incidence and Clinical Course of Atrial Fibrillation and What Remains to be Investigated
Abstract There are many risk factors identified for atrial fibrillation (AF), some of which differ between blacks and whites. These differences and differences in stroke occurrence and clinical course of AF between blacks and whites are reviewed. Risk factors identified to date include age, white race, male sex, body mass index (BMI) ≥30, height ≥173 cm, weight, increased waist circumference, higher levels of systolic (SBP) and diastolic blood pressure (DBP), increased pulse pressure, diagnosis of hypertension, antihypertensive medication use, HDL <40 mg/dL, triglycerides >200 mg/dL, lower heart rate...
Source: Current Cardiovascular Risk Reports - January 27, 2015 Category: Cardiology Source Type: research

Myocardial Function in Saudi Adolescents with Vitamin D Deficiency, Tissue Doppler Imaging Study
This study was conducted to evaluate the effect of 25 (OH)D deficiency on the myocardial function and other echocardiographic variables in adolescent, using Tissue Doppler Imaging (TDI) and to correlate these parameters with 25 (OH)D level. The study included 84 healthy adolescents, consecutively selected from adolescents attending the outpatient clinic of Saad Specialist Hospital, KSA between September 2013 and October 2014. The study population was classified into two groups; vitamin D deficient group with 25(OH)D level less than 20 ng/mL and normal vitamin D (control group) with 25(OH)D equal or more than 30 ng/mL. Both...
Source: Journal of the Saudi Heart Association - June 26, 2015 Category: Cardiology Source Type: research

Myocardial function in Saudi adolescents with vitamin D deficiency: Tissue Doppler imaging study
This study was conducted to evaluate the effect of 25(OH)D deficiency on the myocardial function and other echocardiographic variables in adolescent, using tissue Doppler imaging (TDI) and to correlate these parameters with 25(OH)D level. The study included 84 healthy adolescents, consecutively selected from adolescents attending the outpatient clinic of Saad Specialist Hospital, KSA between September 2013 and October 2014. The study population was classified into two groups; vitamin D deficient group with 25(OH)D level less than 20ng/mL and normal vitamin D (control group) with 25(OH)D equal or more than 30ng/mL. Both gro...
Source: Journal of the Saudi Heart Association - July 17, 2015 Category: Cardiology Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Late-Breaking Data from Pivotal Phase 3 PRECISION Study Demonstrates Significant and Sustained Effect of Aprocitentan on Lowering Blood Pressure for Patients with Difficult-to-Control Hypertension
RARITAN, NJ, November 7, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson, in collaboration with Idorsia Ltd, today announced results from the Phase 3 PRECISION study, which found aprocitentan, an investigational, novel dual endothelin receptor antagonist (ERA), significantly reduced blood pressure (BP) and maintained the effect for up to 48 weeks when added to standardized combination background antihypertensive therapy in patients with difficult-to-control hypertension (sometimes referred to as resistant hypertension). These data were presented as a Late-Breaking Science presentation during the Amer...
Source: Johnson and Johnson - November 7, 2022 Category: Pharmaceuticals Source Type: news

A New Study Shows How Seriously Air Pollution Can Affect Your Heartbeat
For China’s 1.4 billion people, the simple act of breathing has long been something of a risk. Living in the ninth-dirtiest country in the world in terms of air quality, China’s residents lose an average of 2.6 years of life per capita due to atmospheric pollution alone. The greatest risk, of course, is pulmonary, with air pollution leading to shortness of breath, wheezing, coughing, asthma episodes, and chest pain. But pollution affects the heart too; the U.S. Environmental Protection Agency reports that exposure to fine-particulate matter as well as to nitrogen oxides alone can lead to premature aging in bloo...
Source: TIME: Health - May 1, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized climate change Climate Is Everything Environment healthscienceclimate Source Type: news