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Source: The American Journal of Cardiology
Condition: Heart Failure
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Total 105 results found since Jan 2013.
Meta-Analysis Addressing the Effect of Mineralcorticoid Receptor Antagonists on the Risk for New-Onset Atrial Fibrillation
Atrial fibrillation (AF) constitutes the most common, major cardiac arrhythmia worldwide, with an estimated prevalence in the United States equal to 2.3 million affected subjects, projected to increase to 5.6 million by 2050.1 Hypertension and background heart disease (mainly, congestive heart failure) or valve disease represent main risk factors for AF development.1 Other modifiable risk factors are sedentary lifestyle, smoking, obesity, diabetes mellitus, and obstructive sleep apnea.2 AF is associated with a significant increase in the risk for all-cause and cardiovascular death, ischemic stroke, heart failure (HF), isch...
Source: The American Journal of Cardiology - August 13, 2021 Category: Cardiology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Maria Toumpourleka, Michael Doumas Source Type: research
Effect of Near Monopoly in the Left Ventricular Assist Device Market
In 2001, the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart (REMATCH) trial changed the trajectory of the treatment of heart failure when results revealed a clinically meaningful survival benefit and an improved quality of life in patients with the HeartMate XVE left ventricular assist device (LVAD).1 Nearly 2 decades later, LVADs evolved and the results of the ENDURANCE trial revealed that 2 continuous-flow LVADs were noninferior to each other. The HeartWare LVAD (HVAD) was associated with a higher risk of stroke, whereas the use of the HeartMate II (HM2) was associated with more freq...
Source: The American Journal of Cardiology - October 24, 2021 Category: Cardiology Authors: Amit Alam Source Type: research
Long-Term Variation in Kidney Function and Its Impact After Acute Myocardial Infarction
Kidney disease (KD) in patients with acute myocardial infarction (AMI) is associated with major cardiovascular events (MACE). We sought to compare the long-term variation in KD in patients with AMI versus controls and its value as a risk factor for MACE in patients with AMI. A cohort of 300 outpatients with AMI, recruited between 2014 and 2016 in Barcelona, Spain, were compared with a control cohort matched 1:1 based on age and several risk factors for developing KD. Annual estimated glomerular filtration rate (eGFR) using MDRD-4 formula and albuminuria were collected and patients were followed up for the occurrence of MAC...
Source: The American Journal of Cardiology - November 9, 2021 Category: Cardiology Authors: Eduard R ódenas-Alesina, Paolo Cabeza-Martínez, Valeria Zamora-Putin, Ivana Pariggiano, Roxana Escalona, Yassin Belahnech, Montse Delgado de la Cruz, Paolo Calabrò, Ignacio Ferreira-González, Jordi Bañeras Source Type: research
Derivation and Validation of a Clinical Score for Predicting Postoperative Atrial Fibrillation in Noncardiac Elective Surgery (the HART Score)
Postoperative atrial fibrillation (POAF) represents the most frequent cardiac arrhythmia in the surgical setting. It affects almost 3% of all patients over 45 years old who underwent noncardiovascular surgery and is associated with a higher risk of stroke, heart failure, myocardial infarction, and cardiac arrest. The study aimed to assess independent predictors of POAF and derive and validate a score for risk prediction in clinical practice. This was a retrospective cohort study including all consecutive candidates to all types of noncardiac elective surgery attending a cardiological preoperative assessment from 2016 to 2019.
Source: The American Journal of Cardiology - February 23, 2022 Category: Cardiology Authors: Giulia Stronati, Carlo Mondelli, Alessia Urbinati, Giuseppe Ciliberti, Alessandro Barbarossa, Paolo Compagnucci, Michela Casella, Antonio Dello Russo, Federico Guerra Source Type: research
Effect of Sodium-Glucose Cotransporter Inhibitors on Major Adverse Cardiovascular Events and Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus and Atrial Fibrillation
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to lower cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risks. Here, we aimed to evaluate the effect of SGLT2 inhibitors on major adverse cardiovascular events (MACE), a composite of cardiovascular mortality, myocardial infarction, or ischemic stroke and hospitalization for heart failure in patients with T2DM and atrial fibrillation (AF). Using the Korean National Health Insurance Service database, we identified 40,268 patients with T2DM and AF who were newly prescribed oral hypoglycemic drugs ...
Source: The American Journal of Cardiology - July 7, 2022 Category: Cardiology Authors: Chang Hee Kwon, Ye-Jee Kim, Min-Ju Kim, Myung-Jin Cha, Min Soo Cho, Gi-Byoung Nam, Kee-Joon Choi, Jun Kim Source Type: research
CHA2DS2-VASc Score, Mortality and Acute Myocardial Infarction in Patients With Nonvalvular Atrial Fibrillation
Patients with atrial fibrillation (AF) are at increased cardiovascular risk. The CHA2DS2-VASc score (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, previous stroke, vascular disease, age 65 to 74 years, female gender) has been used to predict thromboembolic risk in patients with nonvalvular AF. We aimed to evaluate the association between the CHA2DS2-VASc score and the risk of acute myocardial infarction (AMI) a nd all-cause mortality in patients with AF treated with direct oral anticoagulants (DOACs).
Source: The American Journal of Cardiology - August 12, 2022 Category: Cardiology Authors: Mustafa Gabarin, Tzipi Hornik-Lurie, Saar Minha, Alexander Omelchenko, Rami Barashi, Ziad Arow, Abid Assali, David Pereg Source Type: research
Usefulness of Self-Reported Physical Activity and Clinical Outcomes in Older Patients With Atrial Fibrillation
Current guidelines encourage regular physical activity (PA) to gain cardiovascular health benefit. However, little is known about whether older adults with atrial fibrillation (AF) who engage in the guideline-recommended level of PA are less likely to experience clinically relevant outcomes. We did a retrospective study based on the data from Systemic Assessment of Geriatric Elements in AF (SAGE-AF) prospective cohort study. The study population consisted of older participants with AF ( ≥65 years) and a congestive heart failure, hypertension, age, diabetes, stroke vascular disease, age 65 to 75 and sex(CHA2DS2-VASc) score ≥2.
Source: The American Journal of Cardiology - August 16, 2022 Category: Cardiology Authors: Qiying Dai, Jordy Mehawej, Jane S. Saczynski, Khanh-Van Tran, Hawa O. Abu, Darleen Lessard, Andreas Fillippaios, Tenes Paul, Essa Hariri, Weijia Wang, Mayra Tisminetzky, Apurv Soni, Sakeina Howard-Wilson, Molly E. Waring, Robert J. Goldberg, David D. McMa Source Type: research
Diagnostic and Therapeutic Decision-Making Problems Evoked by Mitral Regurgitation in Heart Failure With Preserved Left Ventricular Ejection Fraction
Given that in the presence of mitral regurgitation (MR), the difference between the left ventricular (LV) end-diastolic and end-systolic volume is no longer the forward stroke volume (SVf) but becomes the sum of SVf and regurgitant volume, it is evident that MR can increase the volumetrically measured ejection fraction (EF) correspondingly with the increased blood volume leaving the LV during the systole.1–3 With aggravation of MR, the regurgitant fraction increases to the detriment of SVf without reduction of the LVEF, even with further reduction of the SVf.
Source: The American Journal of Cardiology - November 3, 2022 Category: Cardiology Authors: Michael Dandel Source Type: research
Why Are Cardiologists Not Prescribing the New Diabetes Medications?
Randomized clinical trials and guidelines from multiple societies have established significant cardiovascular (CV) outcome benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes (T2D). Among patients with T2D, those with known CV disease and those at high risk who are receiving metformin have lower risks of death, myocardial infarction, and stroke if they are treated with GLP-1RAs, and those treated with SGLT2is have reduced risks of hospital admission for heart failure, CV mortality, and all-cause mortality.
Source: The American Journal of Cardiology - December 14, 2022 Category: Cardiology Authors: Lloyd W. Klein Source Type: research
Biventricular Noncompaction Cardiomyopathy in a Patient Presenting With a New Cerebrovascular Event
Noncompaction (NC) cardiomyopathy (NCCM) is a rare, genetically heterogeneous cardiomyopathy (CM) caused by failure to compact the intertrabecular recesses of the myocardium. This condition usually affects the apical segment of the left ventricle, yet there are noted basal segment, biventricular, and right ventricular predominant cases. NCCM is largely diagnosed in the pediatric population; however, there is increasing recognition in older patients with heart failure and stroke and patients with arrhythmias.
Source: The American Journal of Cardiology - January 6, 2023 Category: Cardiology Authors: Himani Madnawat, Issam Atallah, Ali Ahmad, Kishore Harjai Source Type: research
Prevalence of Social Determinants Among US Residents With Heart Failure by Race/Ethnicity and Household Income
Patients with heart failure (HF) are susceptible to the impacts of social determinants of health (SDOH). Previous studies consistently suggest that a greater burden of SDOH is associated with poorer health outcomes.1,2 Data from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study reported that>70% of patients hospitalized with HF had at least 1 SDOH.3 However, the national prevalence of SDOH among patients who are ambulatory and have HF has not been reported and represents an important gap in understanding of HF SDOH.
Source: The American Journal of Cardiology - April 13, 2023 Category: Cardiology Authors: Lajjaben Patel, Nidhish Lokesh, Shreya Rao, Tiffany M. Powell-Wiley, Andrew Sumarsono Source Type: research
Impact of a Novel Score to Predict Left Ventricular Diastolic Dysfunction After Catheter Ablation of Nonparoxysmal Atrial Fibrillation With Preserved Ejection Fraction
This study aimed to develop a novel risk score to predict LV diastolic dysfunction (LVDD) 12 months after AFCA (12-month LVDD) and to evaluate whether the risk score was associated with cardiovascular events (cardiovascular death, transient ischemic attack/stroke, myocardial infarction, or heart failure hospitalization). We studied 397 patients with nonparoxysmal AF with preserved ejectio n fraction who underwent initial AFCA (age: 69 years, women: 32%).
Source: The American Journal of Cardiology - June 13, 2023 Category: Cardiology Authors: Yasuyuki Egami, Hiroaki Nohara, Shodai Kawanami, Hiroki Sugae, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Masamichi Yano, Masami Nishino, Jun Tanouchi Source Type: research
Gender Differences in Atrial Fibrosis and Cardiomyopathy Assessed by Left Atrial Low-Voltage Areas During Catheter Ablation of Atrial Fibrillation
This study aimed to delineate gender differences in the prevalence, predictors, and prognostic impact of left atrial low-voltage areas (LVAs). This observational study included 1,488 consecutive patients who underwent initial ablation for AF. Voltage mapping was performed after pulmonary vein isolation during sinus rhythm.
Source: The American Journal of Cardiology - July 21, 2023 Category: Cardiology Authors: Masaharu Masuda, Yasuhiro Matsuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Taku Toyoshima, Naoko Higashino, Sho Source Type: research
Age-Related Differences in the Contribution of Systolic Blood Pressure and Biomarkers to Cardiovascular Disease Risk Prediction: The Atherosclerosis Risk in Communities (ARIC) Study
We sought to determine how biomarkers known to be associated with hypertension-induced end-organ injury complement the use of systolic blood pressure (SBP) for cardiovascular disease (CVD) risk prediction at different ages. Using data from visits 2 (1990 to 1992) and 5 (2011 to 2013) of the Atherosclerosis Risk in Communities (ARIC) study, 3 models were used to predict CVD (composite of coronary heart disease, stroke, and heart failure). Model A included traditional risk factors (TRFs) except SBP, model B —TRF plus SBP, and model C—TRF plus biomarkers (high-sensitivity troponin T [hsTnT] and N-terminal pro-B-type natri...
Source: The American Journal of Cardiology - August 9, 2023 Category: Cardiology Authors: Mahmoud Al Rifai, George E. Taffet, Kunihiro Matsushita, Salim S. Virani, James De Lemos, Amit Khera, Jarrett Berry, Chiadi Ndumele, David Aguilar, Caroline Sun, Ron C. Hoogeveen, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi Source Type: research
Angiotensin Receptor –Neprilysin Inhibitor Effects on Atherosclerotic Cardiovascular Disease Events: A Meta-Analysis of Randomized Controlled Trials
Sacubitril-valsartan is an angiotensin receptor –neprilysin inhibitor (ARNI) associated with a decreased risk of death and hospitalization for selected patients with heart failure (HF). However, its association with improved atherosclerotic cardiovascular disease (ASCVD) events remains unclear. We performed a meta-analysis to evaluate the assoc iation of ARNI with ASCVD events in patients with HF. We systematically searched PubMed, Embase, Cochrane, and ClinicalTrials.gov for studies comparing ARNIs with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in terms of myocardial infarc...
Source: The American Journal of Cardiology - August 22, 2023 Category: Cardiology Authors: Lis Victoria Ravani, Douglas Mesadri Gewehr, Pedro Calomeni, Mateus de Miranda Gauza, Jussara Pereira, Rhanderson Cardoso, Henrique Barbosa Ribeiro, Edimar Bocchi Source Type: research
