Filtered By:
Condition: Brain Tumor
Nutrition: Zinc
This page shows you your search results in order of date.
Order by Relevance | Date
Total 160 results found since Jan 2013.
< em > hGFAP < /em > -mediated < em > GLI2 < /em > overexpression leads to early death and severe cerebellar malformations with rare tumor formation
iScience. 2023 Jul 28;26(9):107501. doi: 10.1016/j.isci.2023.107501. eCollection 2023 Sep 15.ABSTRACTThe zinc-finger transcription factor GLI2 is frequently amplified in childhood medulloblastoma of the Sonic-hedgehog type (SHH-MB), with or without amplification of NMYC or deletion of TP53. Despite the aggressive tumor behavior, tumorigenesis is not well understood, and adequate mouse models are lacking. Therefore, we generated mice with a GLI2 overexpression under control of the hGFAP-promoter. These mice died within 150 days. The majority only survived until postnatal day 40. They displayed severe cerebellar hypoplasia, ...
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Judith Niesen Irm Hermans-Borgmeyer Christina Kr üger Melanie Schoof Franziska Modemann Ulrich Sch üller Source Type: research
Overexpression of ZEB1 and YAP1 is related to poor prognosis in patients with gliomas with different IDH1 status
CONCLUSIONS: Our study showed that ZEB1 and YAP1 were significantly activated in GBM, and patients with high ZEB1 and YAP1 expression had worse OS. ZEB1 expression was significantly correlated with YAP1 in glioma. ZEB1 and YAP1 coexpression may serve as a useful prognostic biomarker for glioma, and aberrant YAP1 expression may be associated with IDH1 gene state.PMID:37559682 | PMC:PMC10408435
Source: International Journal of Clinical and Experimental Pathology - August 10, 2023 Category: Pathology Authors: Na Miao Zhi-Qiang Wang Ning Zhang Zhi-Ping Ma Li-Ping Su Yang-Yang Zhai Yan-Ran Hu Wei Sang Wei Zhang Source Type: research
