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Prior chronic clopidogrel therapy is associated with increased adverse events and early stent thrombosis.
Abstract Despite the growing use of clopidogrel, limited data exist regarding the prognostic significance of chronic clopidogrel therapy in patients sustaining acute coronary syndrome (ACS). Our aim was to determine whether patients sustaining ACS while on chronic clopidogrel therapy have a worse prognosis than clopidogrel-naïve patients. A total of 5,386 consecutive ACS patients were prospectively characterised and followed-up for 30 days. Of them, 680 (13 %) were treated with clopidogrel prior to the index ACS. Major adverse cardiovascular events (MACE) were defined as death, recurrent ACS, stroke and/or sten...
Source: Thrombosis and Haemostasis - October 8, 2015 Category: Hematology Authors: Asher E, Fefer P, Sabbag A, Herscovici R, Regev E, Mazin I, Shlomo N, Zahger D, Atar S, Hammerman H, Polak A, Beigel R, Matetzky S, PLATIS (Platelets and Thrombosis in Sheba) Study Group Tags: Thromb Haemost Source Type: research

Additional filtering of blood from a cell salvage device is not likely to show important additional benefits in outcome in cardiac surgery.
CONCLUSION: The routine use of an additional filter for transfusion of salvaged blood is unlikely to show important additional benefits. PMID: 30610759 [PubMed - as supplied by publisher]
Source: Transfusion - January 4, 2019 Category: Hematology Authors: de Vries AJ, Vermeijden WJ, van Pelt LJ, van den Heuvel ER, van Oeveren W Tags: Transfusion Source Type: research