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Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men.
CONCLUSIONS: Areduced proportion of undercarboxylated osteocalcin or higherP1NPare associated with increased incidence of MI. UcOC/TOC ratio and P1NP predict risk of MI but not stroke, in a manner distinct from CTX. Further studies are needed to investigate potential mechanisms by which bone turnover markers related to metabolic risk and to collagen formation could modulate cardiovascular risk. PMID: 26308289 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 26, 2015 Category: Endocrinology Authors: Yeap BB, Alfonso H, Chubb SA, Byrnes E, Beilby JP, Ebeling PR, Allan CA, Schultz C, Hankey GJ, Golledge J, Flicker L, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

Sitagliptin Reduces Inflammation and Chronic Immune Cell Activation in HIV+ Adults with Impaired Glucose Tolerance.
CONCLUSION: Sitagliptin had beneficial systemic and adipose anti-inflammatory effects in cART-treated HIV+ adults with impaired glucose tolerance. Large scale, long-term studies should determine if sitagliptin reduces cardiovascular risk and events in HIV+ adults. PMID: 25938633 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - May 4, 2015 Category: Endocrinology Authors: Best C, Struthers H, Laciny E, Royal M, Reeds DN, Yarasheski KE Tags: J Clin Endocrinol Metab Source Type: research

Impact of age-adjusted Insulin-like Growth Factor I on major cardiovascular events after acute myocardial infarction.
CONCLUSIONS: Low IGF-I score is associated with increased risk of all cause-death, recurrent MI and stroke in AMI patients. Whether patients treated by IGF-I axis inhibitors have a specific clinical course after AMI would be worth studying. PMID: 25699636 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 20, 2015 Category: Endocrinology Authors: Bourron O, Le Bouc Y, Berard L, Kotti S, Brunel N, Ritz B, Leclercq F, Tabone X, Drouet E, Mulak G, Danchin N, Simon T Tags: J Clin Endocrinol Metab Source Type: research

Diabetes, myocardial infarction and stroke are distinct and duration-dependent predictors of subsequent cardiovascular events and all-cause mortality in older men.
Conclusions: In older men, increasing duration of diabetes predicts stable increases in all-cause and MI-related mortality and a progressively higher risk of stroke deaths. Prior MI was associated with increased risk of subsequent MI, and prior stroke with subsequent stroke, particularly in the 10-20 years following the first event. Diabetes is a duration-dependent risk factor for cardiovascular events which influences outcomes differently from prior vascular disease. PMID: 25548977 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 30, 2014 Category: Endocrinology Authors: Yeap BB, McCaul KA, Flicker L, Hankey GJ, Almeida OP, Golledge J, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

In older men, higher plasma testosterone or dihydrotestosterone are independent predictors for reduced incidence of stroke but not myocardial infarction.
Conclusions: Higher plasma T or DHT are biomarkers for reduced risk of stroke but not MI. Androgen exposure may influence outcomes following rather than incidence of MI, while androgens but not E2 are independent predictors of stroke risk. Randomised clinical trials are needed to clarify the impact of modifying T or DHT on the risk of stroke in ageing men. PMID: 25268392 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 30, 2014 Category: Endocrinology Authors: Yeap BB, Alfonso H, Paul Chubb SA, Hankey GJ, Handelsman DJ, Golledge J, Almeida OP, Flicker L, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

Hyperandrogenic Oligomenorrhea and Metabolic Risks Across Menopausal Transition.
CONCLUSIONS: Longitudinal evidence suggests that a history of androgen excess and menstrual irregularity is not associated with worsening of metabolic health after menopause. Our findings challenge the notion that a history of concurrent HA and Oligo reflects ongoing cardiometabolic risk in postmenopausal women. PMID: 24517154 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 11, 2014 Category: Endocrinology Authors: Polotsky AJ, Allshouse AA, Crawford SL, Harlow SD, Khalil N, Kazlauskaite R, Santoro N, Legro RS Tags: J Clin Endocrinol Metab Source Type: research

Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyperglycemic Therapies in Type 2 Diabetes.
Conclusions: In people with T2DM, exogenous insulin therapy was associated with an increased risk of diabetes-related complications, cancer, and all-cause mortality. Differences in baseline characteristics between treatment groups should be considered when interpreting these results. PMID: 23372169 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - February 1, 2013 Category: Endocrinology Authors: Currie CJ, Poole CD, Evans M, Peters JR, Morgan CL Tags: J Clin Endocrinol Metab Source Type: research

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