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The use of specific immunoglobulin E in nasal secretions for the diagnosis of allergic rhinitis
ConclusionsIgE level in nasal secretions of subjects with rhinitis is a reliable noninvasive alternative to serum sIgE for diagnosis of allergic rhinitis. Level of Evidence4. Laryngoscope, 2018
Source: The Laryngoscope - February 1, 2018 Category: ENT & OMF Authors: Yifan Meng, Hongfei Lou, Yang Wang, Chengshuo Wang, Luo Zhang Tags: Allergy/Rhinology Source Type: research

Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice
ConclusionsIntranasal administration of PC‐KLH suppressed allergic inflammation in nasal mucosa and antigen‐specific IgE production by downregulating Th2‐type immune response. Intranasal immunization with PC might be useful to prevent AR and upper airway bacterial infection. Level of EvidenceNA Laryngoscope, 2017
Source: The Laryngoscope - November 29, 2017 Category: ENT & OMF Authors: Keiichi Miyashita, Junichiro Ohori, Hiromi Nagano, Satoshi Fukuyama, Yuichi Kurono Tags: Allergy/Rhinology Source Type: research

Botolinum toxin in rhinitis: Literature review and posterior nasal injection in allergic rhinitis
ConclusionBased on our review of current literature, BTX shows clear efficacy on symptoms of both intrinsic and allergic rhinitis, with a good safety profile. Single‐dose posterior nasal injection demonstrates good efficacy and duration of action, with moderate discomfort. Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - July 6, 2017 Category: ENT & OMF Authors: Edward Zhiyong Zhang, Sophocles Tan, Ian Loh Tags: Allergy/Rhinology Source Type: research

Alternaria and Cladosporium calendar of Western Thrace: Relationship with allergic rhinitis symptoms
ConclusionsWe found Cladosporium to be the most frequently detected airborne mould, whereas Alternaria was the most prevalent with regard to sensitization rate. Patients' symptoms score was significantly correlated to spore concentrations. Both fungi were clearly affected by climate factors, such as temperature and relative humidity. These findings are important in AR management. Level of EvidenceN/A. Laryngoscope, 2015
Source: The Laryngoscope - September 15, 2015 Category: ENT & OMF Authors: Michael Katotomichelakis, Christos Nikolaidis, Michael Makris, Efklidis Proimos, Xenophon Aggelides, Theodoros C. Constantinidis, Chariton E. Papadakis, Vassilios Danielides Tags: Allergy/Rhinology Source Type: research

Level of secreted HMGB1 correlates with severity of inflammation in chronic rhinosinusitis
ConclusionOur results showed that HMGB1 is secreted into the extracellular area space in the upper airway, and HMGB1 levels in nasal lavage fluid correlate with severity of inflammation, as assessed by the Lund‐Mackay staging system for chronic rhinosinusitis. These results provide evidence for HMGB1 as an inflammatory mediator associated with the severity of chronic rhinosinusitis. Level of EvidenceN/A. Laryngoscope, 2015
Source: The Laryngoscope - January 30, 2015 Category: ENT & OMF Authors: Hyun Jin Min, Su Jin Kim, Tae Hoon Kim, Hyo Jin Chung, Joo‐Heon Yoon, Chang‐Hoon Kim Tags: Allergy/Rhinology Source Type: research

Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: A proteomic study
ConclusionThis study confirms the significantly higher abundance of apolipoproteins A‐I and AII in allergic rhinitis mucus. Their release seems to be triggered by local mechanisms as an antiinflammatory response to allergens. Level of Evidence3b. Laryngoscope, 2014
Source: The Laryngoscope - November 1, 2014 Category: ENT & OMF Authors: Peter Valentin Tomazic, Ruth Birner‐Gruenberger, Anita Leitner, Barbara Darnhofer, Stefan Spoerk, Doris Lang‐Loidolt Tags: Allergy/Rhinology Source Type: research

Effectiveness of subcutaneous immunotherapy for allergic rhinoconjunctivitis and asthma: A systematic review
ConclusionsGenerally moderate to strong evidence supports the effectiveness of SCIT for treatment of allergic rhinitis and asthma, particularly with single‐allergen immunotherapy regimens. Adverse reactions to SCIT are common, but no deaths were reported in the included studies. Level of Evidence1a Laryngoscope, 2013
Source: The Laryngoscope - July 1, 2013 Category: ENT & OMF Authors: Nkiruka Erekosima, Catalina Suarez‐Cuervo, Murugappan Ramanathan, Julia M. Kim, Yohalakshmi Chelladurai, Jodi B. Segal, Sandra Y. Lin Tags: Systematic Review Source Type: research

Efficacy of intra‐ and extraturbinal microdebrider turbinoplasty in perennial allergic rhinitis
Conclusion: Although both methods showed significant improvement, extraturbinal MAIT seemed more effective for long‐term relief of allergic symptoms. However, the advantages and disadvantages of each method should be considered before choosing the surgical technique.
Source: The Laryngoscope - May 27, 2013 Category: ENT & OMF Authors: Jae Yong Lee Tags: Allergy/Rhinology Source Type: research

Improvement of olfactory function for quality of life recovery
ConclusionsQoL and mental health of patients suffering from chronic sinonasal diseases are totally recovered after treatment, presenting a direct positive relationship with smell improvement. An increase of olfactory function by 3.50 points for AR and 4.75 points for CRS might be considered the cutoff point for patients' QoL significant recovery. Level of Evidence4. Laryngoscope, 2013
Source: The Laryngoscope - May 17, 2013 Category: ENT & OMF Authors: Michael Katotomichelakis, Efthimios Simopoulos, Gregory Tripsianis, Emmanuel Prokopakis, Gerasimos Danielides, Stelios George Velegrakis, Miltos Livaditis, Vassilios Danielides Tags: Allergy/Rhinology Source Type: research

Fast onset of action of sublingual immunotherapy in house dust mite‐induced allergic rhinitis: A multicenter, randomized, double‐blind, placebo‐controlled trial
ConclusionSLIT with a mixture of D.f. and D.p. extract is an effective and safe treatment for patients with house dust mite‐induced AR. Its onset of action can be observed as early as 14 weeks after treatment. Level of Evidence:1B. Laryngoscope, 2012
Source: The Laryngoscope - April 24, 2013 Category: ENT & OMF Authors: De‐Hui Wang, Lei Chen, Lei Cheng, Ke‐Nan Li, Hu Yuan, Ji‐Hong Lu, Han Li Tags: Allergy/Rhinology Source Type: research

Trends in Otolaryngologic Utilization of Computed Tomography for Sinonasal Disorders
ConclusionsDespite widespread availability of imaging and a strong prevalence of sinonasal diagnoses, otolaryngologists' CT ordering patterns have not resulted in increased utilization over the past 6 years. This suggests that otolaryngologists are remaining consistent in their ordering patterns for sinonasal CT. Level of Evidence2c. Laryngoscope, 2013
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Neil Bhattacharyya Tags: Allergy/Rhinology Source Type: research

Comparison of antiallergic effects of pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine in a murine model of allergic rhinitis
Conclusion and Clinical RelevanceBoth PV and PCV suppressed the allergen‐specific T helper 2 response and induced regulatory T cells in a murine model of allergic rhinitis. However, PV and PCV may activate Treg cells via different mechanisms. Level of EvidenceN/A. Laryngoscope, 2013
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Boo‐Young Kim, Ji‐Hyeon Shin, Hyang Rim Park, Sung Won Kim, Soo Whan Kim Tags: Allergy/Rhinology Source Type: research

Expression levels of endogenous hydrogen sulfide are altered in patients with allergic rhinitis
Conclusions:The current findings indicate that, in parallel with increased expression levels of CSE and CBS, H2S is upregulated in nasal mucosa and plasma of allergic patients. Based on localization of CSE and CBS, H2S may play multiple functions in human nasal mucosa, contributing to the development of allergic symptoms such as rhinorrhea, sneezing, and nasal stuffiness. Laryngoscope, 2013
Source: The Laryngoscope - January 9, 2013 Category: ENT & OMF Authors: Se Jin Park, Tae Hoon Kim, Seung Hoon Lee, Hyei Yul Ryu, Ki Hong Hong, Jong Yoon Jung, Gyu Ho Hwang, Sang Hag Lee Tags: Allergy/Rhinology Source Type: research