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Heterogeneity, Subsets, and Plasticity of T Follicular Helper cells in Allergy
Antibody responses are critical for protection against pathogens. However, diseases like allergic rhinitis or food allergy result from aberrant production of IgE antibodies against otherwise innocuous environmental antigens. The production of allergen-specific IgE requires interaction between B cells and CD4+ T cells and a granular understanding of these interactions is required to develop novel therapies for allergic disease. CD4+ T cells are exceptionally heterogeneous in their transcriptional, epigenetic, and proteomic profiles, which poses significant challenges when attempting to define subsets relevant to the study o...
Source: Journal of Allergy and Clinical Immunology - September 4, 2022 Category: Allergy & Immunology Authors: Emily Grydziuszko, Allyssa Phelps, Kelly Bruton, Manel Jordana, Joshua F.E. Koenig Source Type: research
Heterogeneity, subsets, and plasticity of T follicular helper cells in allergy
Antibody responses are critical for protection against pathogens. However, diseases such as allergic rhinitis or food allergy result from aberrant production of IgE antibodies against otherwise innocuous environmental antigens. The production of allergen-specific IgE requires interaction between B cells and CD4+ T cells, and a granular understanding of these interactions is required to develop novel therapies for allergic disease. CD4+ T cells are exceptionally heterogeneous in their transcriptional, epigenetic, and proteomic profiles, which poses significant challenges when attempting to define subsets relevant to the stu...
Source: Journal of Allergy and Clinical Immunology - September 4, 2022 Category: Allergy & Immunology Authors: Emily Grydziuszko, Allyssa Phelps, Kelly Bruton, Manel Jordana, Joshua F.E. Koenig Tags: Rostrum Source Type: research
Atopic Dermatitis With Coexisting Food Allergy in Early Life Is Associated With Childhood Asthma
CONCLUSIONS: AD with FA in early life is strongly associated with asthma and AR in school children, and the early-onset persistent AD with FA had a strong additive effect on the risk of asthma at school age. Classifying AD phenotypes regarding FA in early life will help predict and prevent asthma and AR in school children.PMID:36174996 | DOI:10.4168/aair.2022.14.5.565
Source: Allergy, Asthma and Immunology Research - September 29, 2022 Category: Allergy & Immunology Authors: Sungsu Jung So-Yeon Lee Jisun Yoon Hyun-Ju Cho Min Jee Park Kun Baek Song Eom Ji Choi Eun Young Paek Song-I Yang Eun Lee Soo-Jong Hong PSKC Study Group Source Type: research
