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Condition: Aortic Aneurysm
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Total 36 results found since Jan 2013.
Long non-coding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-Myocardin axis
Am J Physiol Cell Physiol. 2023 Aug 29. doi: 10.1152/ajpcell.00275.2023. Online ahead of print.ABSTRACTAbdominal Aortic Aneurysms (AAAs) are asymptomatic vascular diseases that have life-threatening outcomes. Smooth-muscle cell (SMC) dysfunction plays an important role in AAA development. The contribution of non-coding genome, specifically the role of long non-coding RNAs (lncRNAs) in SMC dysfunction is relatively unexplored. we investigated the role of lncRNA TUG1 in SMC dysfunction. To identify potential lncRNAs relevant to SMC functionality, lncRNA profiling was performed in angiotensin-II treated SMCs. AAA was induced ...
Source: American Journal of Physiology. Cell Physiology - August 29, 2023 Category: Cytology Authors: Ravi Abishek Bharadhwaj Regalla Kumarswamy Source Type: research
The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis
In conclusion, as a promising genetic biomarker for AAA susceptibility, the SNP rs4591246 may exert its effects on AAA risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis.PMID:36931173 | DOI:10.1016/j.intimp.2023.110016
Source: International Immunopharmacology - March 17, 2023 Category: Allergy & Immunology Authors: Tan Li Jingjing Jing Liping Sun Yuehua Gong Jun Yang Chunyan Ma Yuan Yuan Source Type: research
