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Role of ZHX2 in regulating dorsal root ganglion μ-opioid receptor expression in mice with peripheral nerve injuryinduced pain hypersensitivity.
CONCLUSIONS: ZHX2 knockdown in the DRG reverses CCI-induced down-regulation of μ opioid receptor to alleviate periphery nerve injury-induced pain hypersensitivity in mice. PMID: 31511211 [PubMed - in process]
Source: Journal of Southern Medical University - August 29, 2019 Category: Universities & Medical Training Authors: Sheng H, Mo K Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.
Abstract Previous studies have demonstrated that myeloid zinc finger 1 (MZF1) in the dorsal root ganglion (DRG) participates in neuropathic pain induced by chronic-constriction injury (CCI) via regulation of voltage-gated K+ channels (Kv). Emerging evidence indicates that transient receptor potential vanilloid 1 (TRPV1) is involved in the development and maintenance of neuropathic pain. Although it is known that the transcription of TRPV1 is regulated by Kruppel-like zinc-finger transcription factor 7 (Klf7)-and that the structure of TRPV1 is similar to that of Kv-few studies have systematically investigated the r...
Source: Neural Plasticity - October 6, 2019 Category: Neurology Authors: Xing F, Gu H, Niu Q, Fan X, Wang Z, Yuan J, Li Z, Xu JT, Zhang W Tags: Neural Plast Source Type: research