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Signaling sphingolipids are biomarkers for atopic dermatitis prone to disseminated viral infections
CONCLUSION: Our data point to long-term abnormalities in the S1P signaling system as a biomarker for previous disseminated viral diseases and a potential treatment target in recurring infections.PMID:35304160 | DOI:10.1016/j.jaci.2022.02.027
Source: Herpes - March 19, 2022 Category: Infectious Diseases Authors: Evgeny Berdyshev Elena Goleva Irina Bronova Anna S Bronoff Joanne E Streib Kathryn A Vang Brittany N Richers Patricia Taylor Lisa Beck Miguel Villarreal Keli Johnson Gloria David Mark K Slifka Jon Hanifin Donald Ym Leung Source Type: research

Lipid Profiles in Eczema Herpeticum and Eczema Vaccinatum Reflect Changes that Predispose to Disseminated Viral Infection
Atopic dermatitis (AD) is the most common inflammatory skin disease. Less than 5% of AD is complicated by eczema herpeticum (EH) and eczema vaccinatum (EV) but this has led to the CDC recommendation that all AD should not receive smallpox vaccination. Biomarkers of susceptibility to EH and EV are not known.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Evgeny Berdyshev, Elena Goleva, Irina Bronova, Patricia Taylor, Anna Sofia Bronoff, Jon Hanifin, Mark Slifka, Donald Leung Source Type: research

Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis
Eczema vaccinatum (EV) is a life-threatening complication of exposure to smallpox vaccination in patients with atopic dermatitis (AD) characterized by dissemination of vaccinia virus (VV) in the skin and internal organs.1 We have shown that BALB/c mice inoculated with VV at sites of allergic skin inflammation elicited by epicutaneous sensitization with ovalbumin (OVA) exhibit features of EV.2 They include satellite lesions and VV dissemination to internal organs. EV features were absent in mice inoculated with VV in control skin epicutaneously sensitized with saline, suggesting that allergic skin inflammation predisposes ...
Source: Journal of Allergy and Clinical Immunology - January 29, 2016 Category: Allergy & Immunology Authors: Michiko K. Oyoshi, Nicholas Venturelli, Raif S. Geha Tags: Letter to the Editor Source Type: research

Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus
Eczema vaccinatum is a life-threatening complication of smallpox vaccination in patients with atopic dermatitis (AD) characterized by dissemination of vaccinia virus (VV) in the skin and internal organs. Mutations in the filaggrin (FLG) gene, the most common genetic risk factor for AD, confer a greater risk for eczema herpeticum in patients with AD, suggesting that it impairs the response to cutaneous viral infections.
Source: Journal of Allergy and Clinical Immunology - January 30, 2015 Category: Allergy & Immunology Authors: Michiko K. Oyoshi, Jacqueline Beaupré, Nicholas Venturelli, Christopher N. Lewis, Yoichiro Iwakura, Raif S. Geha Source Type: research

Transcutaneous yellow fever vaccination of subjects with or without atopic dermatitis
Conclusions: YFV vaccination of patients with AD through the transcutaneous route revealed that high baseline IgE levels provide a potential biomarker for predicting reduced virus-specific immune memory after transcutaneous infection with a live virus.
Source: Journal of Allergy and Clinical Immunology - December 12, 2013 Category: Allergy & Immunology Authors: Mark K. Slifka, Donald Y.M. Leung, Erika Hammarlund, Hans-Peter Raué, Eric L. Simpson, Susan Tofte, Shahana Baig-Lewis, Gloria David, Henry Lynn, Rob Woolson, Tissa Hata, Henry Milgrom, Jon Hanifin Tags: Atopic dermatitis and skin disease Source Type: research

C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation
Eczema vaccinatum (EV) is a life-threatening complication of exposure to smallpox vaccination in patients with atopic dermatitis (AD). The reason patients with AD are at risk for EV is not known. We showed that inoculation of vaccinia virus (VV) in sites of TH2-dominated allergic skin inflammation elicited by repeated epicutaneous (EC) sensitization with ovalbumin (OVA) promotes local and systemic VV dissemination in mice. We previously showed that the C3a receptor (C3aR) downregulates the TH2 response and promotes the TH1 response locally and systemically in mice epicutaneously sensitized with OVA. We investigated whether...
Source: Journal of Allergy and Clinical Immunology - May 20, 2013 Category: Allergy & Immunology Authors: Lalit Kumar, Bao Lu, Craig Gerard, Raif S. Geha Tags: Letters to the Editor Source Type: research