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Sweet and brittle — Diabetes mellitus and the skeleton
Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), has become a medical mass phenomenon in many parts of the world. Unrestricted access to a high-carbohydrate/high-fat diet in combination with considerably higher energy uptake compared to expenditure has led to a pandemic of the metabolic syndrome and T2DM in many countries. Vascular complications resulting from T2DM include nephropathy, neuropathy and retinopathy as well as ischemic heart disease, peripheral vascular disease and stroke.
Source: Bone - September 9, 2015 Category: Orthopaedics Authors: Lorenz C. Hofbauer, Beata Lecka-Czernik, Markus J. Seibel Tags: Editorial Source Type: research

Bariatric Surgery: "Roux"-minating on Endothelial Cell and HDL Function.
Abstract Obesity, defined as a body mass index ≥ 30 kg/m2, is pandemic. Though prevalence in the United States has plateaued at ~31% of adults (78 million), worldwide obesity rates continue to rise(1). Perhaps more concerning is the high level of childhood obesity: 16.9% in US and ~13% (and rising) in developing countries(2). Why the alarm? Longitudinal studies of overweight or obese individuals have identified a 20 fold increase in risk for developing diabetes mellitus type 2 (T2D) and 1.5 fold increase risk for cardiovascular disease (CVD), including myocardial infarction, stroke and heart failure(3, 4). As ob...
Source: Circulation - February 11, 2015 Category: Cardiology Authors: Brown JD Tags: Circulation Source Type: research

Diabetes, incretin hormones and cardioprotection
The diabetes pandemic In 2012 an estimated 371 million people had diabetes and of those about a half were undiagnosed. That number is set to expand to 552 million by 2030. Type 2 diabetes mellitus (T2DM) constitutes 85–95% of all diabetes in high income nations and may account for an even greater proportion in their low and middle income counterparts (figure 1). As a global pandemic, diabetes claimed the lives of 4.8 million people in 2012, half of whom were below the age of 60 years.w1 The predominant cause of morbidity and mortality in diabetes is cardiovascular disease, with at least a twofold excess risk of ...
Source: Heart - September 9, 2014 Category: Cardiology Authors: Myat, A., Redwood, S. R., Gersh, B. J., Yellon, D. M., Marber, M. S. Tags: Diabetic heart disease, Education in Heart, Drugs: cardiovascular system, Epidemiology, Diabetes, Metabolic disorders Source Type: research

Evaluation of Central and Peripheral Neuropathy in Type 2 Diabetes: A Case-Control Study (P6.094)
Conclusion: Abnormal VEP may be due to structural damage to myelinated optic nerve fibres or retinal ganglion cells. Central neuropathy is very common in DM. It is related to duration of DM and not HbA1c unlike PNP which is related to both. Central neuropathy occurs even prior to development of retinopathy or PNP. Hence VEP is a non invasive and sensitive screening tool for early neurological involvement in DM.Disclosure: Dr. Eswaradass has nothing to disclose. Dr. Kalidoss has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Eswaradass, P. V., Kalidoss, R. Tags: Neuromuscular Disease Source Type: research

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