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Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction
In conclusion, FYXN exerts a protective effect against DMCI by promoting angiogenesis via the Rab1/AT1R pathway, which provides strong evidence for the therapeutic effect of FYXN on DMCI.
Source: Frontiers in Pharmacology - February 17, 2021 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory effect of the extracts from the branch of Taxillus yadoriki being parasitic in Neolitsea sericea in LPS-stimulated RAW264.7 cells
In this study, we evaluated the anti-inflammatory effect of extracts of branch from Taxillus yadoriki being parasitic in Neolitsea sericea (TY-NS-B) using in vitro model. TY-NS-B significantly inhibited LPS-induced secretion of NO and PGE2 in RAW264.7 cells. TY-NS-B was also observed to inhibit LPS-mediated iNOS COX-2 expression. In addition, TY-NS-B attenuated production of inflammatory cytokines such as TNF-α and IL-1β induced by LPS. TY-NS-B blocked LPS-mediated inhibitor of IκB-α, and inhibited p65 translocation to the nucleus and NF-κB activation. Furthermore, TY-NS-B reduced the phosphorylation of MAPKs such as ...
Source: Biomedicine and Pharmacotherapy - May 11, 2018 Category: Drugs & Pharmacology Source Type: research

Ginkgo biloba Extract Reduces High-Glucose-Induced Endothelial Reactive Oxygen Species Generation and Cell Adhesion Molecule Expression by Enhancing HO-1 Expression via Akt/eNOS and P38 MAP Kinase Pathways.
CONCLUSION: GBE could reduce high glucose-induced endothelial adhesion via enhancing HO-1 expression through the Akt/eNOS and P38/MAPK pathways. Our findings suggest a potential strategy targeting on HO-1 induction by GBE for endothelial protection in the presence of high glucose such as that in diabetes mellitus. PMID: 23357604 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - January 25, 2013 Category: Drugs & Pharmacology Authors: Tsai HY, Huang PH, Lin FY, Chen JS, Lin SJ, Chen JW Tags: Eur J Pharm Sci Source Type: research