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Specialty: Neurology
Condition: Dementia

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Total 1006 results found since Jan 2013.

Systematic Review and Meta-Analysis of Interventions Tested in Animal Models of Lacunar Stroke Basic Sciences
Conclusions— No intervention has yet been tested in sufficient range and depth to support translation to clinical trial. There is limited reporting of measures to reduce the risk of bias and evidence for a substantial publications bias.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Pedder, H., Vesterinen, H. M., Macleod, M. R., Wardlaw, J. M. Tags: Acute Cerebral Infarction, Cerebral Lacunes, Emergency treatment of Stroke Basic Sciences Source Type: research

Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula Brief Reports
Conclusions— Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Garcia-Cordero, I., Sedeno, L., Fraiman, D., Craiem, D., de la Fuente, L. A., Salamone, P., Serrano, C., Sposato, L., Manes, F., Ibanez, A. Tags: Computerized tomography and Magnetic Resonance Imaging, Other imaging, Pathology of Stroke Brief Reports Source Type: research

Progressive Cognitive Deficits in a Mouse Model of Recurrent Photothrombotic Stroke Brief Reports
Conclusions— Our results show progressive cognitive deficits in a mouse model of recurrent photothrombotic stroke. The presented model resembles the clinical features of human multi-infarct dementia and enables the investigation of its pathophysiological mechanisms and the evaluation of treatment strategies.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Schmidt, A., Diederich, K., Strecker, J.-K., Geng, B., Hoppen, M., Duning, T., Schabitz, W.-R., Minnerup, J. Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

Methodological Factors in Determining Risk of Dementia After Transient Ischemic Attack and Stroke: (II) Effect of Attrition on Follow-Up Clinical Sciences
Conclusions— Exclusion of patients unavailable for clinic follow-up reduces the measured risk of postevent dementia. Use of multiple follow-up methods, including home visits, telephone assessments, and consent, to access primary care records substantially increases ascertainment of longer-term dementia outcomes.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Pendlebury, S. T., Chen, P.-J., Welch, S. J. V., Cuthbertson, F. C., Wharton, R. M., Mehta, Z., Rothwell, P. M., for the Oxford Vascular Study Tags: Behavioral Changes and Stroke Clinical Sciences Source Type: research

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia Clinical Sciences
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Baseline Cognitive Function, Recurrent Stroke, and Risk of Dementia in Patients With Stroke Clinical Sciences
Conclusions— Patients with stroke with low MMSE scores are at high risk of dementia over time, even in the absence of a recurrent stroke, and should therefore be followed closely for further cognitive decline.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Rist, P. M., Chalmers, J., Arima, H., Anderson, C., MacMahon, S., Woodward, M., Kurth, T., Tzourio, C. Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

ICARUSS, the Integrated Care for the Reduction of Secondary Stroke trial: rationale and design of a randomized controlled trial of a multimodal intervention to prevent recurrent stroke in patients with a recent cerebrovascular event, ACTRN = 12611000264987
ConclusionThe ICARUSS study aims to recruit and follow up patients between 2007 and 2013 and demonstrate the effectiveness of exposure to the ICARUSS model in stroke survivors to reduce recurrent stroke or vascular events and promote the implementation of best practice risk factor management at primary care level.
Source: International Journal of Stroke - April 1, 2015 Category: Neurology Authors: J. Joubert, S. M. Davis, G. J. Hankey, C. Levi, J. Olver, G. Gonzales, G. A. Donnan Tags: Protocol Source Type: research

Does Stroke Contribute to Racial Differences in Cognitive Decline? Clinical Sciences
Conclusions— In this population-based cohort of older adults, incident stroke did not explain black–white differences in cognitive decline or impact cognition differently by race.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Levine, D. A., Kabeto, M., Langa, K. M., Lisabeth, L. D., Rogers, M. A. M., Galecki, A. T. Tags: Health policy and outcome research, Acute Cerebral Infarction Clinical Sciences Source Type: research

Does the Influence of Stroke on Dementia Vary by Different Levels of Prestroke Cognitive Functioning?: A Cohort Study Clinical Sciences
Conclusions— Stroke and prestroke cognition were independently associated with increased probability of poststroke dementia. Stroke results in disproportionate increase in the risk of dementia when premorbid cognitive functioning is high.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Dregan, A., Wolfe, C. D. A., Gulliford, M. C. Tags: Clinical Sciences Source Type: research

Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to prevent stroke, the Stroke Council of the American Heart Association convened a writing committee to evaluate existing evidence, to discuss clinical considerations, and to offer suggestions for future research on stroke prevention in patients with 3 cardinal manifestations of silent cerebrovascular disease: silent brain infarcts...
Source: Stroke - January 22, 2017 Category: Neurology Authors: Eric E. Smith, Gustavo Saposnik, Geert Jan Biessels, Fergus N. Doubal, Myriam Fornage, Philip B. Gorelick, Steven M. Greenberg, Randall T. Higashida, Scott E. Kasner, Sudha Seshadri Tags: Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Probable REM sleep behavior disorder and risk of stroke: A prospective study
Conclusions: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Ma, C., Pavlova, M., Liu, Y., Liu, Y., Huangfu, C., Wu, S., Gao, X. Tags: All Cerebrovascular disease/Stroke, All Sleep Disorders, Cohort studies ARTICLE Source Type: research

Cognitive performance after stroke – The Framingham Heart Study
ConclusionsClinical stroke is associated with subsequent poorer performance in multiple cognitive domains. This association cannot be entirely explained by the individual's cognitive function prior to stroke or by concomitant vascular risk factor levels.
Source: International Journal of Stroke - April 1, 2014 Category: Neurology Authors: Galit Weinstein, Sarah R. Preis, Alexa S. Beiser, Rhoda Au, Margaret Kelly‐Hayes, Carlos S. Kase, Philip A. Wolf, Sudha Seshadri Tags: Research Source Type: research

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
Conclusions: Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease.
Source: Neurology - January 11, 2016 Category: Neurology Authors: Traylor, M., Zhang, C. R., Adib-Samii, P., Devan, W. J., Parsons, O. E., Lanfranconi, S., Gregory, S., Cloonan, L., Falcone, G. J., Radmanesh, F., Fitzpatrick, K., Kanakis, A., Barrick, T. R., Moynihan, B., Lewis, C. M., Boncoraglio, G. B., Lemmens, R., T Tags: MRI, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, All Genetics, Association studies in genetics ARTICLE Source Type: research

Structural MRI markers of brain aging early after ischemic stroke
Conclusions: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Werden, E., Cumming, T., Li, Q., Bird, L., Veldsman, M., Pardoe, H. R., Jackson, G., Donnan, G. A., Brodtmann, A. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia ARTICLE Source Type: research

Validity of stroke severity assessment using medical records in a population-based cohort
Initial stroke severity is an important prognostic factor for outcome after acute stroke, in terms of functional dependency, post-stroke dementia, and mortality.1,2 Whilst the majority of stroke patients who are admitted to the hospital with stroke have substantial neurological deficits, over half of all strokes that occur in the population qualify as minor stroke,3 and are managed often in outpatient care.4 Given the important differences between minor and major stroke in prognosis and management, it is important to distinguish patients on the basis of stroke severity, but assessment outside of specialised stroke centres ...
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2023 Category: Neurology Authors: Jacqueline J. Claus, Brian B.P. Berghout, M. Kamran Ikram, Frank J. Wolters Source Type: research