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Neuropsychiatric Symptoms of COVID-19 Explained by SARS-CoV-2 Proteins ’ Mimicry of Human Protein Interactions
Conclusion: SARS-CoV-2-human protein interactions may lead to the development of delirium, psychosis, seizures, encephalitis, stroke, sensory impairments, peripheral nerve diseases, and autoimmune disorders. Our findings are also supported by the previous in vivo and in vitro studies from other viruses. Further in vivo and in vitro studies using the proteins that are pointed here, could pave new targets both for avoiding and reversing neuropsychiatric presentations.
Source: Frontiers in Human Neuroscience - March 23, 2021 Category: Neuroscience Source Type: research

Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach
J Proteomics. 2021 Apr 22:104244. doi: 10.1016/j.jprot.2021.104244. Online ahead of print.ABSTRACTNicotine is a prominent active compound in tobacco and many smoking cessation products. Some of the biological effects of nicotine are well documented in in vitro and in vivo systems; however, nominal data are available concerning the time-dependent changes on protein and phosphorylation events in response to nicotine. Here, we profiled the proteomes of SH-SY5Y and A549 cell lines subjected to acute (15 min, 1 h and 4 h) or chronic (24 h, 48 h) nicotine exposures. We used sample multiplexing (TMTpro16) and quantified more than...
Source: Journal of Proteomics - April 25, 2021 Category: Biochemistry Authors: Jos é Navarrete-Perea Steven P Gygi Joao A Paulo Source Type: research