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Source: Atherosclerosis
Condition: Mitochondrial Disease
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Total 24 results found since Jan 2013.
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
CONCLUSIONS: Although the results from both multivariable-adjusted prospective and basis MR analyses did not show an association between low mtDNA and increased risk of ischemic stroke, in-depth MR sensitivity analyses may suggest evidence for a causal relationship.PMID:35793595 | DOI:10.1016/j.atherosclerosis.2022.06.1012
Source: Atherosclerosis - July 6, 2022 Category: Cardiology Authors: Leon G Martens Jiao Luo Marieke J H Wermer Ko Willems van Dijk Sara H ägg Felix Grassmann Raymond Noordam Diana van Heemst Source Type: research
Mitochondrial Implications in Cardiovascular Aging and Diseases: The Specific Role of Mitochondrial Dynamics and Shifts
Int J Mol Sci. 2022 Mar 9;23(6):2951. doi: 10.3390/ijms23062951.ABSTRACTCardiovascular disease has been, and remains, one of the leading causes of death in the modern world. The elderly are a particularly vulnerable group. The aging of the body is inevitably accompanied by the aging of all its systems, and the cardiovascular system is no exception. The aging of the cardiovascular system is a significant risk factor for the development of various diseases and pathologies, from atherosclerosis to ischemic stroke. Mitochondria, being the main supplier of energy necessary for the normal functioning of cells, play an important ...
Source: Atherosclerosis - March 25, 2022 Category: Cardiology Authors: Anastasia V Poznyak Tatiana V Kirichenko Evgeny E Borisov Nikolay K Shakhpazyan Andrey G Kartuesov Alexander N Orekhov Source Type: research
Age-related vascular changes exemplified by the carotid artery
Gefasschirurgie. 2022 Jun 24;27(4):1-7. doi: 10.1007/s00772-022-00901-5. Online ahead of print.ABSTRACTOne of the main risk factors for the presence of carotid stenosis and carotid-related stroke is age. The aim of this review article is to present the current state of knowledge on age-related vascular changes using carotid stenosis as an example.Vascular aging (vascular senescence) is a decrease of structural and functional properties of the vessel wall that takes place on different levels. At the multicellular level an increase in vessel volume and diameter as well as intima media thickness occurs with age mainly due to ...
Source: Atherosclerosis - July 5, 2022 Category: Cardiology Authors: Benedikt Reutersberg Philip D üppers Anna-Leonie Menges Claudia Schrimpf Alexander Zimmermann Jaroslav Pelisek Source Type: research
Role of mitochondrial DNA copy number in incident cardiovascular diseases and the association between cardiovascular disease and type 2 diabetes: A follow-up study on middle-aged women
CONCLUSIONS: Lower baseline mtDNA-CN is associated with incident CVD and may have a mediating effect on the association between T2D and CVD; however, this novel observation needs to be confirmed in future studies.PMID:34876297 | DOI:10.1016/j.atherosclerosis.2021.11.020
Source: Atherosclerosis - December 8, 2021 Category: Cardiology Authors: Kristina Sundquist Jan Sundquist Karolina Palmer Ashfaque A Memon Source Type: research
The role of mitochondria-targeting miRNAs in intracerebral hemorrhage
Curr Neuropharmacol. 2022 May 6. doi: 10.2174/1570159X20666220507021445. Online ahead of print.ABSTRACTNon-traumatic intracerebral hemorrhage (ICH) is the most common type of hemorrhagic stroke, most often occurring between the ages of 45 and 60. Arterial hypertension (AH) is most often the cause of ICH, followed by atherosclerosis, blood diseases, inflammatory changes in cerebral vessels, intoxication and vitamin deficiencies. Cerebral hemorrhage can occur by diapedesis or as a result of a ruptured vessel. AH is difficult to treat; requires surgery and can lead to disability or death. One of the important directions in th...
Source: Atherosclerosis - May 7, 2022 Category: Cardiology Authors: Ilgiz Gareev Ozal Beylerli Yanchao Liang Enzhou Lu Tatiana Ilyasova Albert Sufianov Galina Sufianova Huaizhang Shi Aamir Ahmad Guang Yang Source Type: research
The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research
The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis
This article examines the mechanisms and potential targets of Nrf2 affecting endothelial cell function to improve atherosclerosis and to provide ideas for the development of new CVD treatments.PMID:35600333 | PMC:PMC9119788 | DOI:10.1155/2022/4287711
Source: Atherosclerosis - May 23, 2022 Category: Cardiology Authors: Zixia Huang Mingyue Wu Lijin Zeng Deming Wang Source Type: research
A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells
J Cell Biol. 2022 Jul 4;221(7):e202109144. doi: 10.1083/jcb.202109144. Epub 2022 Jun 13.ABSTRACTAtherosclerosis, the major cause of myocardial infarction and stroke, results from converging inflammatory, metabolic, and biomechanical factors. Arterial lesions form at sites of low and disturbed blood flow but are suppressed by high laminar shear stress (LSS) mainly via transcriptional induction of the anti-inflammatory transcription factor, Kruppel-like factor 2 (Klf2). We therefore performed a whole genome CRISPR-Cas9 screen to identify genes required for LSS induction of Klf2. Subsequent mechanistic investigation revealed ...
Source: Atherosclerosis - June 13, 2022 Category: Cardiology Authors: Brian G Coon Sushma Timalsina Matteo Astone Zhen W Zhuang Jennifer Fang Jinah Han Jurgen Themen Minhwan Chung Young Joo Yang-Klingler Mukesh Jain Karen K Hirschi Ai Yamamato Louis-Eric Trudeau Massimo Santoro Martin A Schwartz Source Type: research
Acute myocardial infarction in a patient with MELAS syndrome: a possible link?
CONCLUSIONS: In light of the recent evidence suggesting a possible link between mitochondrial disorders and atherosclerosis, we speculate that MELAS syndrome may have played a role in the pathogenesis of coronary artery disease in our patient. Further investigations are needed to confirm a pathogenetic link.PMID:35767235 | DOI:10.23736/S2724-5683.22.06021-5
Source: Atherosclerosis - June 29, 2022 Category: Cardiology Authors: Joseph Cosma Alessandro Russo Sofia Schino Martina Belli Ruggiero Mango Gaetano Chiricolo Eugenio Martuscelli Enrica G Mariano Source Type: research
Role of Platelet in Parkinson's Disease: Insights into Pathophysiology & amp; Theranostic Solutions
Ageing Res Rev. 2022 Jul 4:101681. doi: 10.1016/j.arr.2022.101681. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second-most-common neurodegenerative disease characterized by motor and non-motor dysfunctions, which currently affects about 10 million people worldwide. Gradual death and progressive loss of dopaminergic neurons in the pars compacta region of substantia nigra results in striatal dopamine deficiency in PD. Specific mutation with further aggregation of α-synuclein in the intraneuronal inclusion bodies is considered the neuropathological hallmark of this disease. PD is often associated with vario...
Source: Atherosclerosis - July 7, 2022 Category: Cardiology Authors: Samir Kumar Beura Abhishek Ramachandra Panigrahi Pooja Yadav Sunil Kumar Singh Source Type: research
Molecular explanation of Wnt/ βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders
Mol Biol Rep. 2022 Sep 15. doi: 10.1007/s11033-022-07863-7. Online ahead of print.ABSTRACTThe symptoms of ageing are somewhat different and can lead to the altered role of the cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems. Ageing is an autonomous cardiovascular risk factor. In the ageing rat heart, oxidative and inflammatory stress, immune cell infiltration, increasing myeloperoxidase function, elevated caspase-3 activity, and protein fibronectins were detected and associated with ageing and cardiovascular disease. The intracellular Ca2 + homeostasis disturbed in an older heart dra...
Source: Atherosclerosis - September 15, 2022 Category: Cardiology Authors: Khalid Saad Alharbi Yogendra Singh Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Imran Kazmi Fahad A Al-Abbasi Sami I Alzarea Dinesh Kumar Chellappan Sachin Kumar Singh Kamal Dua Gaurav Gupta Source Type: research
Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling
Biomed Res Int. 2022 Dec 24;2022:3959845. doi: 10.1155/2022/3959845. eCollection 2022.ABSTRACTVascular remodeling refers to changes in the size, contraction, distribution, and flow rate of blood vessels and even changes in vascular function. Vascular remodeling can cause cardiovascular and cerebrovascular diseases. It can also lead to other systemic diseases, such as pulmonary hypertension, pulmonary atherosclerosis, chronic obstructive pulmonary disease, stroke, and ascites of broilers. Hypoxia is one of the main causes of vascular remodeling. Prolonged hypoxia or intermittent hypoxia can lead to loss of lung ventilation,...
Source: Atherosclerosis - January 3, 2023 Category: Cardiology Authors: Xiaojuan Huang Elif Ece Akg ün Khalid Mehmood Hui Zhang Zhaoxin Tang Ying Li Source Type: research
