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A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Boosting 'cellular garbage disposal' can delay the aging process, UCLA biologists report
UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.   The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.   "Aging is a major risk factor for the development and progression of many neurodegenerative diseases," said David Walke...
Source: UCLA Newsroom: Health Sciences - May 6, 2013 Category: Universities & Medical Training Source Type: news

Different Clinical Manifestations of MELAS in a Single Family (P5.073)
Conclusions: In 1992, diagnostic criteria for MELAS included symptom onset prior to 40-years of age. Numerous case reports have found patients presenting with MELAS after age 40 with genetic confirmation of the mutation. Today, the criteria have been eased and a diagnosis of MELAS should be considered in the appropriate clinical setting at any age.Disclosure: Dr. Koshy has nothing to disclose. Dr. Kamins has nothing to disclose. Dr. Mishra has nothing to disclose. Dr. Flippen has received personal compensation in an editorial capacity for the Journal of Graduate Medical Education and UpToDate. Dr. Singh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Koshy, S., Kamins, J., Mishra, S., Flippen, C., Singh, S. Tags: Hereditary Muscle Diseases: Genetics and Phenotype Source Type: research