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Condition: Autoimmune Disease

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Total 2213 results found since Jan 2013.

Wheat allergy in celiac children
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Source: Pediatric Allergy and Immunology - September 11, 2015 Category: Allergy & Immunology Authors: M F Martín‐Muñoz, D Rivero, A Díaz Perales, I Polanco, S Quince Tags: Letter to the Editor Source Type: research

Single Nucleotide Polymorphism rs 2476601 of PTPN22 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population.
This study suggests that the rs2476601 polymorphism of PTPN22 gene is mono-morphic in Iranian population, containing only C allele.Considering that previous studies in other populations reported the T allele as the risk allele at this locus, the present study concluded that rs2476601 play no role in susceptibility to RA and other autoimmune diseases in Iranian population. This finding has significant future clinical implications in determining the strategy for risk assessment and predictive testing for such diseases in Iranian population. PMID: 26547712 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Ahmadloo S, Taghizadeh M, Akhiani M, Salimzadeh A, Keramatipour M Tags: Iran J Allergy Asthma Immunol Source Type: research

In Vitro Generation of IL-35-expressing Human Wharton's Jelly-derived Mesenchymal Stem Cells Using Lentiviral Vector.
Abstract Human Wharton's Jelly-derived Mesenchymal Stem Cells (hWJ-MSCs) are easily available cells without transplant rejection problems or ethical concerns compared to bone-marrow-derived MSCs for prospective clinical applications. These cells display immunosuppressive properties and may be able to play an important role in autoimmune disorders. Regulatory T-cells (Treg) are important to prevent autoimmune disease development. Interleukin 35 (IL-35) induces the proliferation of Treg cell populations and reduces the activity of T helper 17 (Th17) and T helper 1 (Th1) cells, which play a central role in initiation...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Amari A, Ebtekar M, Moazzeni S, Soleimani M, Mohammadi-Amirabad L, Tahoori M, Massumi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of HLA-DRB1 Alleles with Ulcerative Colitis in the City of Kerman, South Eastern Iran.
In this study, for the first time, we aimed to investigate the association between HLA-DRB1 types and UC in the population of Kerman, a city southeast Iran.HLA typing was performed among 85 UC patients and 95 healthy controls using PCR amplification, employing sequence specific primers (PCR-SSP). The DRB1 frequencies were determined in the patients and controls.HLA-DRB1*04 was negatively associated with UC. Furthermore, HLA-DRB1*13 was significantly associated with severity of the disease (p=0.01) among UC patients.This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective r...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Mohammadi M, Rastin M, Rafatpanah H, Abdoli-Sereshki H, Zahedi M, Nikpoor A, Baneshi M, Hayatbakhsh M Tags: Iran J Allergy Asthma Immunol Source Type: research

Th22 Cells Contribution in Immunopathogenesis of Rheumatic Diseases.
Abstract Newly identified T helper cell 22 (Th22) is a subset of CD4+T cells with specific properties apart from other known CD4+ T cell subsets with distinguished gene expression and function. Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF-α). The levels of Th22 and related cytokine IL-22 are increased in various autoimmune diseases and positively associated with some rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, behcet's disease, ankylosing spondylitis and psori...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Azizi G, Simhag A, M-M-El Rouby N, Mirshafiey A Tags: Iran J Allergy Asthma Immunol Source Type: research

Design, Synthesis and In Vitro Release Studies of Co-drugs for Rheumatoid Arthritis.
Abstract Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammation that may affect many tissues and organs, but principally the synovial joints. The tendency for joint destruction is greatest in the early stages of disease hence current trend is to introduce a disease-modifying anti-rheumatic drug (DMARD) immediately after the diagnosis of RA in a step- up approach which is generally followed by its combination with a corticosteroid or NSAID. DMARD suppresses inflammatory activity over a long time-frame thus improving day to day function, and also prevents, lessens or dela...
Source: Inflammation and Allergy Drug Targets - December 1, 2015 Category: Allergy & Immunology Authors: Kashmira P, Suneela D, Shakuntalah C, Poorvashree J Tags: Inflamm Allergy Drug Targets Source Type: research

GABAergic Agonists Modulate the Glutamate Release from Frontal Cortex Synaptosomes of Rats with Experimental Autoimmune Encephalomyelitis.
Abstract Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease that mimics many of the clinical and pathological features of multiple sclerosis. We have previously described a significant diminution in the GABAergic regulation of glutamate release from synaptosomes of EAE rats isolated during the acute stage of the disease. In order to explore the possible metabolic pathways responsible for this alteration, in this work we evaluate the direct effect of different GABAergic agonists on the glutamate release and concomitant synapsin I phosphorylation in synaptosomes from the frontal...
Source: Inflammation and Allergy Drug Targets - December 1, 2015 Category: Allergy & Immunology Authors: Hurst NF, Chanadaya NL, Roth GA Tags: Inflamm Allergy Drug Targets Source Type: research

Interleukin-21 Is Associated with the Pathogenesis of Lumbar Disc Herniation.
This study was aimed to  determine  the  association  between  IL-21  levels  and  pain  scores  in  LDH  patients compared to healthy controls.We enrolled 34 LDH patients and 20 healthy controls in this study. The LDH patients underwent surgery. Pain intensity was recorded using visual analogue scale (VAS) scores preoperatively. Serum IL-21 and IL-17 levels in the peripheral blood were determined using enzyme-linked immunosorbent assay. Disc tissue was examined using western blot and quantitative reverse-transcription polymerase chain reaction to determine IL-21, IL-17, and cyclooxygenase (COX)-2 expression, a...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2015 Category: Allergy & Immunology Authors: Xue H, Yao Y, Wang X, Zhang F, Jiang X, Liu J, Wang H, Li Y, Wang X, Li H, Zhang J Tags: Iran J Allergy Asthma Immunol Source Type: research

Neuroprotective Effects of Transplanted Mesenchymal Stromal Cells-derived Human Umbilical Cord Blood Neural Progenitor Cells in EAE.
Abstract Multiple Sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. The aim of this study was to investigate the neuroprotective effects of transplanted human umbilical cord blood mesenchymal stromal cells (UCB-MSC) derived neural progenitor cell (MDNPC) in EAE, an experimental model of MS. To initiate neuronal differentiation of UCB-MSCs, the pre-induction medium was removed and replaced with induction media containing retinoic acid, b FGF, h EGF, NGF, IBMX and ascorbic acid for one week. The expression of neural genes was examined in comparison to control group b...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 1, 2015 Category: Allergy & Immunology Authors: Rafieemehr H, Kheyrandish M, Soleimani M Tags: Iran J Allergy Asthma Immunol Source Type: research

Vaccination and Induction of Autoimmune Diseases.
Abstract Vaccines have been suspected of playing a role in inducing autoimmune disease (AID) for a long time. However, apart from certain specific vaccine strains and complications (such as the swine flu vaccine and Guillain- Barré syndrome in 1976, thrombocytopenia and the Measles-Mumps-Rubella vaccine), this role has not been established. In spite of this, many isolated cases or series of cases of arthritis, vasculitis, and central or peripheral nervous system symptoms following vaccination have been reported. These cases tend to be very infrequent and usually only the short-term outcomes are described. This pa...
Source: Inflammation and Allergy Drug Targets - January 4, 2016 Category: Allergy & Immunology Authors: Toussirot É, Bereau M Tags: Inflamm Allergy Drug Targets Source Type: research

Microbiome Regulation of Autoimmune, Gut and Liver associated Diseases.
Abstract Extensive analysis of the complexity and diversity of microbiota using metagenomics in the gut and other body sites has provided evidence that dysbiosis occurs in many disease states. With the application of next generation sequencing technology this research is starting to uncover the impact of microbiota on metabolic, physiological and immunological pathways and elucidate the cellular and molecular mechanisms involved. To highlight these advances we have focused on autoimmunity and gut and liver related diseases and discuss the opportunities and challenges of translating microbiome research towards its ...
Source: Inflammation and Allergy Drug Targets - January 28, 2016 Category: Allergy & Immunology Authors: Singh B Tags: Inflamm Allergy Drug Targets Source Type: research

Quantitative Evaluation of BAFF, HMGB1, TLR 4 AND TLR 7 Expression in Patients with Relapsing Remitting Multiple Sclerosis.
Abstract Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by a complex immune response. Because of the complex nature of MS pathogenesis, a panel of biomarkers derived from different platforms will be required to reflect disease-related alterations. Monitoring and evaluation of molecules associated with the pathogenesis of the disease would provide useful information on disease progression and therapeutic assessment. In view of this, we evaluated the mRNA expression levels of B-cell activating factor (BAFF), high mobility group box 1 (HMGB-1), Toll like receptor (TLR...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 31, 2016 Category: Allergy & Immunology Authors: Hamid KM, Nejati A, Shoja Z, Mollaei-Kandelousd Y, Doosti R, Mirshafiey A, Tafakhori A, Sahraian MA, Marashi SM Tags: Iran J Allergy Asthma Immunol Source Type: research

Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.
In this study, the mRNA expression levels of some hypothalamic peptides were investigated in C57BL/6 female mice with experimental autoimmune encephalomyelitis (EAE). Animals were randomly divided into two control and EAE groups. EAE was induced by administration of myelin oligodendrocyte glycoprotein (MOG) with complete Ferund's adjuvant and pertussis toxin. Twenty-first days following immunization, mice were decapitated to remove the brains. Then, the expression profiles of prepro-orexin, orexin 1 receptors (OX1R) and orexin 2 receptors (OX2R) in hypothalamic region were assessed using real-time PCR method. In this study...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 31, 2016 Category: Allergy & Immunology Authors: Fatemi I, Shamsizadeh A, Roohbakhsh A, Ayoobi F, Sanati MH, Motevalian M Tags: Iran J Allergy Asthma Immunol Source Type: research

Immunomodulatory Effect of Chymotrypsin in CNS Is Sex-independent: Evidence of Anti-inflammatory Role for IL-17 in EAE.
Abstract Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory autoimmune diseases of the central nervous system. Chymotrypsin is a serine protease with immunomodulatory effect in the peripheral organs. We previously demonstrated the immunomodulatory effect of chymotrypsin in ameliorating the EAE in female Lewis rats. However, there are sex-based differences in the immune system, drug activity, and CNS structure and composition. In addition, female gender is a better prognostic indicator of MS and males are more severely affected by EAE than females. Conseq...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 31, 2016 Category: Allergy & Immunology Authors: Ghaffarinia A, Parvaneh S, Jalili C, Riazi-Rad F, Yaslianifard S, Pakravan N Tags: Iran J Allergy Asthma Immunol Source Type: research

Mannose-binding Lectin Mediated Complement Pathway in Autoimmune Neurological Disorders.
Abstract Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been po...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 31, 2016 Category: Allergy & Immunology Authors: Farrokhi M, Dabirzadeh M, Dastravan N, Etemadifar M, Ghadimi K, Saadatpour Z, Rezaei A Tags: Iran J Allergy Asthma Immunol Source Type: research