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The Predictive Capacity of the Buffalo Concussion Treadmill Test After Sport-Related Concussion in Adolescents
Conclusion This study found that the ΔHR (HRt minus resting HR) correlated with duration of clinical recovery in participants who were prescribed relative rest or a placebo-stretching program but not for participants prescribed sub-threshold aerobic exercise. A ΔHR of ≤50 bpm on the BCTT was 73% sensitive and 78% specific for predicting delayed recovery in concussed adolescents prescribed the current standard of care (i.e., cognitive and physical rest). This has implications for planning team and school activities in adolescents who sustain SRC. Ethics Statement This study was carried out in acco...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam. Introduction Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Thalamic alterations remote to infarct appear as focal iron accumulation and impact clinical outcome
AbstractSee Duering and Schmidt (doi:10.1093/awx135) for a scientific commentary on this article.Thalamic alterations have been observed in infarcts initially sparing the thalamus but interrupting thalamo-cortical or cortico-thalamic projections. We aimed at extending this knowledge by demonstrating within vivo imaging sensitive to iron accumulation, one marker of neurodegeneration, that (i) secondary thalamic alterations are focally located in specific thalamic nuclei depending on the initial infarct location; and (ii) such secondary alterations can contribute independently to the long-term outcome. To tackle this issue, ...
Source: Brain - May 25, 2017 Category: Neurology Source Type: research

The quantitative analysis of temporal lobes and Hippocampi in patients diagnosed with transient global amnesia (TGA). (P7.137)
CONCLUSIONS: While limited by study sample and retrospective analysis, our data suggests no statistically significant difference in TL (p≤0.1),hippocampi volume(p≤0.09), or TL lobe volume asymmetry (p≤0.3), although a trend was noted for hippocampal volume asymmetry(p≤0.07) compared to the control group.Disclosure: Dr. Boddepalli has nothing to disclose. Dr. Reyes has nothing to disclose. Dr. Salgado has received personal compensation in an editorial capacity from Belvoir Media Group. Dr. Candocia has nothing to disclose. Dr. Gandhi has nothing to disclose. Dr. Oppenheimer. has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Boddepalli, R., Reyes, D., Salgado, E., Candocia, F., Gandhi, R., Oppenheimer., A. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke, Depression, and Anxiety Source Type: research

Circadian sleep/wake rhythm abnormalities as a risk factor of a poststroke apathy
ConclusionThese results indicate that early poststroke alterations of sleep/wake circadian rhythms – easily evaluated by actigraphy – are associated with a higher risk of poststroke apathy at three‐months. In terms of clinical outcomes, our results provide targets for very early identification of patients at risk to develop apathy after stroke and for assessing when to start specific therapy to optimize rehabilitation efficiency.
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Charlotte Cosin, Igor Sibon, Mathilde Poli, Michèle Allard, Sabrina Debruxelles, Pauline Renou, François Rouanet, Willy Mayo Tags: Research Source Type: research

Progressive limbic encephalopathy: Problems and prospects
Conclusion: All patients who present with new onset neuropsychiatric symptoms need to be evaluated for sub-acute infections, inflammation, autoimmune limbic encephalitis and paraneoplastic syndrome. A repeated 20 minute EEG is a very effective screening tool to detect organicity.
Source: Annals of Indian Academy of Neurology - May 17, 2014 Category: Neurology Authors: Sadanandavalli Retnaswami ChandraRoopa SeshadriYasha ChikabasaviahThomas Gregor Issac Source Type: research