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Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia
Publication date: Available online 3 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Rafael Pazinatto Aguiar, Lígia Mendes Soares, Erika Meyer, Fernanda Canova da Silveira, Humberto Milani, Adrian Newman-Tancredi, Mark Varney, Jos Prickaerts, Rúbia M. Weffort de OliveiraAbstractPharmacological interventions that selectively activate serotonin 5-hydroxytryptramine-1A (5-HT1A) heteroreceptors may prevent or attenuate the consequences of brain ischemic episodes. The present study investigated whether the preferential 5-HT1A postsynaptic receptor agonist NLX-101 (a.k.a. F15599) m...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 4, 2019 Category: Psychiatry Source Type: research

Evaluation of the curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the patients with post stroke depression associated with anxiety
ConclusionThe curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the anxiety state and motor function of the patients with post stroke depression is superior to that of escitalopram. With regard to the improvement of depression, this acupuncture manipulation was provided with the characteristic of rapid onset, and its long-term efficacy is equivalent to that of escitalopram. In terms of the improvement of activities of daily living, the curative effect of the two methods is equally well.
Source: World Journal of Acupuncture Moxibustion - July 10, 2018 Category: Complementary Medicine Source Type: research

Efficacy of escitalopram oxalate for patients with post-stroke depression
This retrospective study investigated the efficacy and safety of escitalopram oxalate (ESO) for the treatment of post-stroke depression (PSD). A total of 115 patients with PSD were included in this study. A total of 65 patients underwent ESO (Intervention group). A total of 50 patients received acupressure (Control group). The outcome measurements included Montgomery-Åsberg Depression Rating Scale (MADRS), Hamilton Anxiety Rating Scale (HAM-A), and Sheehan Disability Scale (SDS). In addition, we also recorded the adverse events in this study. At the end of 8-week treatment, ESO showed greater efficacy in depression, measured by MADRS (P 
Source: Medicine - April 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Evaluation of the curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the patients with post stroke depression associated with anxiety
Conclusion The curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the anxiety state and motor function of the patients with post stroke depression is superior to that of escitalopram. With regard to the improvement of depression, this acupuncture manipulation was provided with the characteristic of rapid onset, and its long-term efficacy is equivalent to that of escitalopram. In terms of the improvement of activities of daily living, the curative effect of the two methods is equally well.
Source: World Journal of Acupuncture Moxibustion - March 17, 2018 Category: Complementary Medicine Source Type: research