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Determinants for a low dose of alteplase and its relationship to a lower intracerebral bleeding risk in acute ischemic stroke
Conclusions: Patients with increasing age, a higher baseline systolic blood pressure, and previous ischemic stroke were at a higher odd of receiving a low-dose of alteplase. The low-dose was associated with a lower risk of developing symptomatic intracranial hemorrhage.PMID:36313231 | PMC:PMC9608043 | DOI:10.7150/ijms.76105
Source: International Journal of Medical Sciences - October 31, 2022 Category: Biomedical Science Authors: Jie Chen Hangfeng Li Hanhan Lei Shuangfang Fang Qilin Yuan Yangui Chen Dongping Chen Ronghua Chen Yixian Zhang Jin Wei Guangliang Chen Zhiting Chen Nan Liu Hou-Wei Du Source Type: research

Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice
Conclusion Although secreted platelet 5-HT does not appear to play a crucial role in the development of reperfusion injury after stroke, it is essential to amplify the second phase of platelet activation through SOCE and plays an important role in thrombus stabilization.
Source: PLoS One - January 22, 2016 Category: Biomedical Science Authors: Karen Wolf et al. Source Type: research

Demonstration of proof-of-concept of < i > StrokeShield < /i > system for complete closure and occlusion of the left atrial appendage for non-valvular atrial fibrillation therapy
by Mark S. Slaughter, Gretel Monreal, Steven C. Koenig, Guruprasad A. Giridharan, Landon H. Tompkins, Jorge H. Jimenez In the US, the most significant morbidity and mortality associated with non-valvular atrial fibrillation (NVAF) is embolic stroke, with 90% of thrombus originating from the left atrial appendage (LAA). Anticoagulation is the preferred treatment for the prevention of stroke in NVAF patients, but cl inical studies have demonstrated high levels of non-compliance and increased risk of bleeding or ineligibility for anticoagulation therapy, especially in the elderly population where the incidence of NVAF is hig...
Source: PLoS One - June 22, 2021 Category: Biomedical Science Authors: Mark S. Slaughter Source Type: research

Comparison of short-term clinical outcomes between low-dose prasugrel and clopidogrel as part of triple antithrombotic therapy in patients requiring oral anticoagulant therapy and percutaneous coronary intervention
ConclusionsCombination of low-dose prasugrel and DOAC was associated with lower incidence of MI, ischemic stroke, and blood transfusion. Low-dose prasugrel may be feasible as part of triple therapy in patients undergoing PCI.
Source: PLoS One - July 28, 2022 Category: Biomedical Science Authors: Hideki Kitahara Source Type: research

Therapeutic efficacy of direct oral anticoagulants and vitamin K antagonists for left ventricular thrombus: Systematic review and meta-analysis
ConclusionsEfficacy and adverse outcomes of therapy with DOACs and VKAs do not differ. Randomized controlled trials are needed to determine the optimal anticoagulant strategy.
Source: PLoS One - July 26, 2021 Category: Biomedical Science Authors: Tetsuji Kitano Source Type: research

Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study
ConclusionsIn Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation, rivaroxaban may be associated with a similar risk of major bleeding but a lower risk of thromboembolism compared with warfarin. The potential benefit of 10 mg of rivaroxaban in this population requires further investigation.
Source: PLoS One - April 8, 2021 Category: Biomedical Science Authors: Yi-Cheng Lin Source Type: research

Impact of sex differences on outcomes in patients with non-valvular atrial fibrillation undergoing left atrial appendage closure: A single-center experience
Int J Med Sci. 2021 Mar 3;18(9):1990-1998. doi: 10.7150/ijms.53221. eCollection 2021.ABSTRACTFemale patients affected by non-valvular atrial fibrillation (NVAF) have a higher risk of stroke compared with male patients. Left atrial appendage (LAA) closure has been demonstrated as a reasonable alternative to warfarin therapy for stroke prevention in patients with NVAF. However, the impact of sex-related differences on outcomes in patients undergoing LAA closure (LAAC) remains unclear. Our study investigated the differences in LAAC efficacy and safety endpoints between sexes. 387 consecutive patients undergoing WATCHMAN devic...
Source: International Journal of Medical Sciences - April 14, 2021 Category: Biomedical Science Authors: Mingzhong Zhao Felix Post Manuela Muenzel Cody R Hou Thorsten Keil Jiangtao Yu Source Type: research

Prognostic impact of catheter ablation in patients with asymptomatic atrial fibrillation
ConclusionsIn the post-hoc analysis of the matched AF cohort, catheter ablation as compared with conservative management was associated with better long-term clinical outcomes among asymptomatic AF patients only when the previous AF-related complications were present.
Source: PLoS One - December 15, 2022 Category: Biomedical Science Authors: Tetsuma Kawaji Source Type: research

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