• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The efficacy and safety of aspirin plus dipyridamole versus aspirin in secondary prevention following TIA or stroke: A meta-analysis of randomized controlled trials
Conclusions: Aspirin plus dipyridamole combination therapy was beneficial in reducing the recurrence of stroke, and did not increase the bleeding event. Hence, aspirin plus dipyridamole combination therapy is effective and safe for the secondary prevention of stroke.
Source: Journal of the Neurological Sciences - July 19, 2013 Category: Neurology Authors: Xia Li, Guoyu Zhou, Xueying Zhou, Shengnian Zhou Tags: Original Articles Source Type: research

Early initiation of new oral anticoagulants in acute stroke and TIA patients with nonvalvular atrial fibrillation
Conclusions: The NOAC may be safe in acute stroke or TIA patients with NVAF. A large, prospective study is needed to confirm this.
Source: Journal of the Neurological Sciences - June 5, 2013 Category: Neurology Authors: Kensaku Shibazaki, Kazumi Kimura, Junya Aoki, Naoki Saji, Kenichiro Sakai Tags: Original Articles Source Type: research

Reservations against new oral anticoagulants after stroke and cerebral bleeding
Abstract: Dabigatran, rivaroxaban, and apixaban are the new oral anticoagulants (NOAC) which have been investigated in patients with atrial fibrillation (AF) for primary and secondary prevention of stroke and thromboembolism. In these trials NOAC had a similar efficacy and safety profile compared to traditional vitamin-K-antagonists such as warfarin. We advise caution in the use of NOAC in patients with stroke or cerebral hemorrhage because of the following reasons:1) Patients with cerebral bleeding were excluded from the trials. 2) Stroke within 14days and severe stroke within 6months before screening were exclusion crite...
Source: Journal of the Neurological Sciences - April 29, 2013 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Opinion Source Type: research

Intravenous thrombolysis with rt-PA for acute ischemic stroke within 24h of a transient ischemic attack
Conclusion: TIA within 24h prior to ischemic stroke can portend severe intracerebral bleeding in patients qualified to iv-thrombolysis with the use of rt-PA.
Source: Journal of the Neurological Sciences - March 13, 2014 Category: Neurology Authors: Piotr Sobolewski, Waldemar Brola, Małgorzata Wiszniewska, Wiktor Szczuchniak, Małgorzata Fudala, Mariusz Domagalski, Monika Śledzińska-Dźwigał Tags: Original Articles Source Type: research

Gastrointestinal complications after ischemic stroke
Ischemic stroke is an important cause of morbidity and mortality, and currently the leading cause of adult disability in developed countries. Stroke is associated with various non-neurological medical complications, including infections and thrombosis. Gastrointestinal complications after stroke are also common, with over half of all stroke patients presenting with dysphagia, constipation, fecal incontinence or gastrointestinal bleeding. These complications are associated with increased hospital length of stay, the development of further complications and even increased mortality.
Source: Journal of the Neurological Sciences - September 4, 2014 Category: Neurology Authors: Carlos R. Camara-Lemarroy, Beatriz E. Ibarra-Yruegas, Fernando Gongora-Rivera Tags: Review article Source Type: research

Intravenous Alteplase for acute ischemic stroke in patients with current malignant neoplasm
Conclusions: Our experience suggests that IV thrombolysis does not appear to increase the risk of hemorrhagic complications in current non-metastatic cancer patients in absence of additional risk factors of bleeding. In addition, these patients showed clinical improvement after IV thrombolysis, although replication of our findings in a randomized controlled trial is required to confirm our results.
Source: Journal of the Neurological Sciences - January 14, 2013 Category: Neurology Authors: Manuel Cappellari, Monica Carletti, Nicola Micheletti, Giampaolo Tomelleri, Domenico Ajena, Giuseppe Moretto, Paolo Bovi Tags: Original Articles Source Type: research

A raging fire in acute lacunar stroke: Inflammation, blood–brain barrier dysfunction and the origin of cerebral microbleeds
Cerebral microbleeds (CMBs) detected on T2*-weighted gradient-recalled echo or susceptibility-weighted MRI sequences have sparked scientific and clinical interest over the past 15years . Extensive research has provided compelling evidence that CMBs are an important marker of bleeding-prone microangiopathies, including hypertensive arteriopathy and cerebral amyloid angiopathy, and might thus be associated with a higher risk for stroke, cognitive impairment, and mortality. The exact pathophysiological mechanisms of CMBs formation, however, are still poorly understood. Histopathological studies indicate that radiologically-de...
Source: Journal of the Neurological Sciences - March 21, 2014 Category: Neurology Authors: Andreas Charidimou, David J. Werring Tags: Editorials Source Type: research

Spontaneous sternocleidomastoid muscle hematoma following thrombolysis for acute ischemic stroke
We report the case of an 83y.o. woman with right facio-brachio-crural hemiparesis, left deviation of the head and aphasia who developed, after thrombolytic therapy, a spontaneous sternocleidomastoid muscle hematoma that regressed few days later. To our knowledge, this is the first case reported in the literature of asymptomatic and spontaneous skeletal muscle hematoma following thrombolysis for the treatment of acute ischemic stroke. The occurrence of lateral cervical tuberculosis lymphadenitis ipsilateral to sternocleidomastoid muscle hematoma may suggest a causal relationship between local chronic inflammation of active ...
Source: Journal of the Neurological Sciences - April 28, 2014 Category: Neurology Authors: Nadia Mariagrazia Giannantoni, Giacomo Della Marca, Aldobrando Broccolini, Fabio Pilato, Paolo Profice, Roberta Morosetti, Pietro Caliandro, Giovanni Frisullo Tags: Letters to the Editor Source Type: research

Idarucizumab elimination of dabigatran minutes before systemic thrombolysis in acute ischemic stroke
We report the case of a 76-year-old woman, who received intravenous thrombolysis for acute treatment of an ischemic stroke immediately after elimination of dabigatran by intravenous application of the monoclonal antibody fragment, idarucizumab, which specifically reverses dabigatran anticoagulation. Currently, the RE-VERSE AD clinical trial is testing idarucizumab in two indications, uncontrolled bleeding and the need for urgent interventions or surgery.
Source: Journal of the Neurological Sciences - September 7, 2016 Category: Neurology Authors: Joachim G. Schulz, Bernard Kreps Tags: Letter to the Editor Source Type: research

Idarucizumab-facilitated intravenous thrombolysis in acute stroke with dabigatran: Two cases with hemorrhagic transformation
Idarucizumab is a monoclonal antibody fragment specifically designed for counteracting the effect of a direct oral anti-coagulant (DOAC), namely dabigatran [1]. In a phase III clinical trial, idarucizumab is able to normalize the coagulation profiles in patients suffered from life-threatening bleeding or prepared for emergent intervention [2]. Idarucizumab-facilitated intravenous thrombolysis (IT) was thus considered as a reasonable therapeutic strategy for patients with acute ischemic stroke under dabigatran treatment [3].
Source: Journal of the Neurological Sciences - March 14, 2018 Category: Neurology Authors: Yi-Te Tsai, Yu-Jen Hsiao, Li-Kai Tsai, Pao-Sheng Yen, Fu-Yu Lin, Ching-Hua Lu, Chen-Wen Fang Tags: Letter to the Editor Source Type: research

Cilostazol-based dual anti-platelet agents for Asian patients: An updated network meta-analysis
Antiplatelet therapy, including aspirin, has been used for the secondary prevention of non-cardioembolic ischemic stroke [1]. Because patients who have a higher risk of recurrent stroke need antiplatelet agents with higher efficacy than aspirin, dual antiplatelet therapy (DAPT) has been used in cases requiring higher efficacy, such as the acute stage of stroke or high-risk patients [2]. However, DAPT is notably associated with an increased risk of bleeding like a two-edged sword [3]. Aspirin plus clopidogrel is recommended for a few weeks after acute ischemic stroke, preventing bleeding risk from not exceeding the power of...
Source: Journal of the Neurological Sciences - October 8, 2022 Category: Neurology Authors: Seung Jin Jung, Sung Ryul Shim, Bum Joon Kim, Jin-Man Jung Source Type: research

CNS-disease affecting the heart: Brain–heart disorders
Abstract: There are a number of hereditary and non-hereditary central nervous system (CNS) disorders, which directly or indirectly affect the heart (brain–heart disorders). The most well-known of these CNS-disorders are epilepsy, stroke, subarachanoid bleeding, bacterial meningitis, and head injury. In addition, a number of hereditary and non-hereditary neurodegenerative disorders may impair cardiac functions. Affection of the heart may manifest as arrhythmias, cardiomyopathy, or autonomic dysfunction. Rarer cardiac complications of CNS disorders include heart failure, systolic or diastolic dysfunction, myocardial infarc...
Source: Journal of the Neurological Sciences - July 10, 2014 Category: Neurology Authors: Josef Finsterer, Karim Wahbi Tags: Reviews Source Type: research

Response to Letter to the Editor from Dr. Dale Ding: Molecular insights into aneurysmal subarachnoid hemorrhage and cerebral vasospasm from analysis of coated-platelets
We thank Dr. Dale Ding for his thoughtful comments. We agree that the current data , in conjunction with prior results showing lower levels of coated-platelets in spontaneous intracerebral hemorrhage (ICH) and an inverse relationship between these levels and the bleed size , as well as the presence of lower coated-platelet levels in patients with early hemorrhagic transformation after non-lacunar stroke and in dogs with a bleeding diathesis support a role in hemostasis for this subset of procoagulant platelets. We also agree that a critical study with potential significant impact would be monitoring of coated-platelet leve...
Source: Journal of the Neurological Sciences - January 13, 2014 Category: Neurology Authors: Calin I. Prodan Tags: Letters to the Editor Source Type: research

Biomarkers of vasospasm development and outcome in aneurysmal subarachnoid hemorrhage
Abstract: Aneurysmal subarachnoid hemorrhage (SAH) is a neurologic emergency caused by a brain aneurysm burst, resulting in a bleeding into the subarachnoid space. Its incidence is estimated between 4 and 28/10,000 inhabitants and it is the main cause of sudden death from stroke. The prognosis of patients with SAH is directly related to neurological status on admission, to the magnitude of the initial bleeding, as well as to the development of cerebral vasospasm (CVS). Numerous researchers have studied the role of different biomarkers in CVS development. These biomarkers form part of the metabolic cascade that is triggered...
Source: Journal of the Neurological Sciences - May 8, 2014 Category: Neurology Authors: Ana Rodríguez-Rodríguez, Juan José Egea-Guerrero, Zaida Ruiz de Azúa-López, Francisco Murillo-Cabezas Tags: Original Articles Source Type: research

Pages: 1  2