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Total 404 results found since Jan 2013.
The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling
CONCLUSIONS: Our results confirm differential TL1A expression (including its secreted and non-secreted form) in asthma, which modulates remodeling. The shared mechanism of action by which nsTL1A and secreted TL1A exert their effects on asthma development might be mediated via the nuclear factor-κB pathway. The TL1A-DR3 axis presents a promising therapeutic target in asthma.PMID:35255540 | PMC:PMC8914606 | DOI:10.4168/aair.2022.14.2.233
Source: Allergy, Asthma and Immunology Research - March 7, 2022 Category: Allergy & Immunology Authors: Jintao Zhang Dong Zhang Yun Pan Xiaofei Liu Jiawei Xu Xinrui Qiao Wenjing Cui Liang Dong Source Type: research
CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway
J Cell Mol Med. 2022 Jan 28. doi: 10.1111/jcmm.17206. Online ahead of print.ABSTRACTOur previous study indicated that adhesion molecule catenin alpha-like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and asthma animal model but little is known about how the CTNNAL1 affects asthma pathogenesis. To reveal the direct relationship between asthma and CTNNAL1, CTNNAL1-deficient mouse model in bronchopulmonary tissue was constructed by introducing CTNNAL1-siRNA sequence using adeno-associated virus (AAV) as vector. The mouse model of asthma was established by stimulation of house dust mite (HDM). Afte...
Source: J Cell Mol Med - January 29, 2022 Category: Molecular Biology Authors: Di Wu Wang Jiang Caixia Liu Lexin Liu Furong Li Xiaodi Ma Lang Pan Chi Liu Xiangping Qu Huijun Liu Xiaoqun Qin Yang Xiang Source Type: research
