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Condition: Asthma
Drug: Polyethylene Glycol

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Total 106 results found since Jan 2013.

Covid-19 vaccine reactions and suspected polyethylene glycol allergy: a pediatric case series
Studies have demonstrated tolerance in high risk patients receiving Covid-19 m-RNA vaccines containing polyethylene glycol (PEG) with rare reactions.There is limited pediatric data regarding safety in receiving PEG containing Covid-19 vaccines with a history of prior hypersensitivity reactions to PEG containing chemotherapy (PEG-CTX).
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Laditan, A. Martone, D. Doshi Tags: P010 Source Type: research

Split-Dosing of COVID-19 Vaccines Provides Non-Inferior Antibody Responsiveness to Conventional Vaccine Dosing
coronavirus disease 2019 (COVID-19), messenger RNA (mRNA), polyethylene glycol (PEG), American College of Allergy, Asthma, and Immunology (ACAAI), Receptor Binding Domain Protein (RBD), Spike Protein 1 (S1), Nucleocapsid (N), mean fluorescent intensity (MFI), natural infection (NI), significant differences in mean (SEM), MMR (measles, mumps, rubella), inhaled corticosteroids (ICS)
Source: Annals of Allergy, Asthma and Immunology - September 6, 2022 Category: Allergy & Immunology Authors: Amal Musa, Macy Wood, Andrew Rorie, Sara M. May, Joel Van De Graaff, Jill A. Poole Tags: Letters Source Type: research

Successful mRNA COVID-19 vaccination in a patient with a history of severe polyethylene glycol anaphylaxis
The mechanism of action behind anaphylactic reactions to the mRNA COVID-19 vaccines remains unknown, but the excipient polyethylene glycol, PEG-2000, has been implicated. Initial recommendations were made for ...
Source: Allergy, Asthma and Clinical Immunology - June 20, 2022 Category: Allergy & Immunology Authors: Daniel H. Li, Erika Lee and Christine Song Tags: Case report Source Type: research

Allergy evaluation of messenger RNA vaccine reactions is crucial, with a specific role for polyethylene glycol testing
Ann Allergy Asthma Immunol. 2022 Jul;129(1):22-23. doi: 10.1016/j.anai.2022.01.046.NO ABSTRACTPMID:35717132 | DOI:10.1016/j.anai.2022.01.046
Source: Annals of Allergy, Asthma and Immunology - June 18, 2022 Category: Allergy & Immunology Authors: Pragya Shrestha Cosby Allen Stone Source Type: research

True, true, and unrelated: Stop routine testing to vaccine excipients for suspected vaccine allergy
Vaccines for infectious diseases contain multiple minor ingredients called excipients, such as egg ovalbumin, polysorbate (PS), polyethylene glycol (PEG), neomycin, thimerosal, and other contaminants (eg, lactose, yeast, formaldehyde, gelatin, latex).1,2 Allergic reactions occurring to vaccines are rare, but focus on vaccine excipients as the provoking cause.3 Examples of this include egg ovalbumin in yellow fever (YF), gelatin in measles, mumps, and rubella (MMR) and several other vaccines, yeast in hepatitis B vaccines, and casein with diphtheria tetanus acellular pertussis (DTaP).
Source: Annals of Allergy, Asthma and Immunology - June 16, 2022 Category: Allergy & Immunology Authors: Matthew Greenhawt Tags: Perspective Source Type: research

Allergy evaluation of messenger RNA vaccine reactions is crucial, with a specific role for polyethylene glycol testing
The US Food and Drug Administration granted emergency authorization to both Pfizer-BioNTech's BNT162B2 messenger RNA (mRNA) and Moderna's mRNA-1273 coronavirus disease 2019 (COVID-19) vaccines in December 2020. Uncommon (2.5-4.7 events per million) anaphylactic reactions were observed that had not been reported in phase III studies which excluded individuals with a history of an allergy to a vaccine or components of the mRNA vaccines. From that moment on, allergists have played a crucial role in the vaccine rollout and have clarified a very specific role for polyethylene glycol (PEG) testing.
Source: Annals of Allergy, Asthma and Immunology - June 16, 2022 Category: Allergy & Immunology Authors: Pragya Shrestha, Cosby Allen Stone Tags: Perspective Source Type: research

Allergic Reactions to the COVID-19 vaccine (ARCOV) study: the McGill University Health Center (MUHC) experience
CONCLUSION: In this cohort of patients with a history of anaphylaxis and increased risk of allergic reactions to the COVID-19 vaccines, following allergist evaluation, including negative PEG skin testing, the vaccine was safely administered without any serious adverse events.PMID:35609744 | PMC:PMC9124043 | DOI:10.1016/j.anai.2022.05.014
Source: Annals of Allergy, Asthma and Immunology - May 24, 2022 Category: Allergy & Immunology Authors: Faisal ALMuhizi Michael Fein Sofianne Gabrielli Louise Gilbert Christos Tsoukas Moshe Ben-Shoshan Ana M Copaescu Ghislaine A C Isabwe Source Type: research

The role of anti-polyethylene glycol (PEG) IgM, IgG, or IgE antibodies in COVID mRNA vaccine anaphylaxis is unknown. We highlight a case with preexisting anti-PEG antibodies that tolerated vaccination
Ann Allergy Asthma Immunol. 2022 May 20:S1081-1206(22)00445-8. doi: 10.1016/j.anai.2022.05.013. Online ahead of print.NO ABSTRACTPMID:35605816 | DOI:10.1016/j.anai.2022.05.013
Source: Annals of Allergy, Asthma and Immunology - May 23, 2022 Category: Allergy & Immunology Authors: Kristen B Corey Grace Koo Cosby A Stone Susan F Kroop William H Fissell Steven Kozlowski Zhao-Hua Zhou Elizabeth J Phillips Source Type: research

Allergic reactions to the coronavirus disease 2019 vaccine (ARCOV) study
Messenger RNA coronavirus disease 2019 (COVID-19) vaccines have been associated with allergic reactions. A history of anaphylaxis has been suggested as a risk factor for such reactions. Polyethylene glycol (PEG) has been proposed as a possible culprit allergen.
Source: Annals of Allergy, Asthma and Immunology - May 21, 2022 Category: Allergy & Immunology Authors: Faisal ALMuhizi, Michael Fein, Sofianne Gabrielli, Louise Gilbert, Christos Tsoukas, Moshe Ben-Shoshan, Ana M. Copaescu, Ghislaine Annie Clarisse Isabwe Tags: Original Article Source Type: research

Allergic Reactions to the COVID-19 vaccine (ARCOV) study: the McGill University Health Center (MUHC) experience
: mRNA-COVID-19 vaccines have been associated with allergic reactions. A history of anaphylaxis has been suggested as a risk factor for such reactions. Polyethylene glycol (PEG) has been proposed as a possible culprit allergen.
Source: Annals of Allergy, Asthma and Immunology - May 21, 2022 Category: Allergy & Immunology Authors: Faisal ALMuhizi, Michael Fein, Sofianne Gabrielli, Louise Gilbert, Christos Tsoukas, Moshe Ben-Shoshan, Ana M. Copaescu, Ghislaine A.C Isabwe Source Type: research

A case of coronavirus disease 2019 messenger RNA vaccine tolerance and immune response despite presence of anti-polyethylene glycol antibodies
The role of anti-polyethylene glycol (PEG) immunoglobulin (Ig)M, IgG, or IgE antibodies in coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccine anaphylaxis is unknown. We highlight a case with preexisting anti-PEG antibodies that tolerated vaccination.
Source: Annals of Allergy, Asthma and Immunology - May 20, 2022 Category: Allergy & Immunology Authors: Kristen B. Corey, Grace Koo, Cosby A. Stone, Susan F. Kroop, William H. Fissell, Steven Kozlowski, Zhao-Hua Zhou, Elizabeth J. Phillips Tags: Letters Source Type: research

The role of anti-polyethylene glycol (PEG) IgM, IgG, or IgE antibodies in COVID mRNA vaccine anaphylaxis is unknown. We highlight a case with preexisting anti-PEG antibodies that tolerated vaccination
A 60-year-old woman with debilitating gout experienced HLA-B*58:01-restricted allopurinol drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Two years later, following therapeutic failure with febuxostat, pegloticase was trialed. Twelve days following initial infusion, she developed angioedema and a diffuse erythematous pruritic rash. She self-treated with diphenhydramine, but symptoms persisted for two days. She then developed shortness of breath and throat constriction, requiring antihistamines and systemic steroids from an outside emergency department.
Source: Annals of Allergy, Asthma and Immunology - May 20, 2022 Category: Allergy & Immunology Authors: Kristen B. Corey, Grace Koo, Cosby A. Stone, Susan F. Kroop, William H. Fissell, Steven Kozlowski, Zhao-Hua Zhou, Elizabeth J. Phillips Source Type: research

Anaphylaxis to Ultrasound-Enhancing Agent with Transient Elevation in Serum Tryptase
Ultrasound enhancing agents (UEA) are used to enhance ultrasound image quality. The UEA that are approved for use by the FDA include perfluorocarbon or sulfur hexafluoride microbubbles stabilized with “shells” composed of either lipid monolayer or albumin. The lipid based UEA contain polyethylene glycol (PEG). 1
Source: Annals of Allergy, Asthma and Immunology - April 22, 2022 Category: Allergy & Immunology Authors: Alyssa Kerber, James T.C. Li Tags: Letters Source Type: research