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Anti-NMDAR encephalitis secondary to acute necrotizing encephalopathy caused by herpes simplex virus infection in infants: Case series
CONCLUSION: Infants with ANE associated with HSV can develop secondary anti-NMDAR encephalitis, recognition of which is critical to ensure the appropriate institution of immunotherapy after active CNS infection has been ruled out.PMID:37689014 | DOI:10.1016/j.clineuro.2023.107955
Source: Herpes - September 9, 2023 Category: Infectious Diseases Authors: Jia Zhang Jinfeng Liu Jianjun Wang Jing Gan Source Type: research

Multiple Organ Dysfunction Secondary to Herpes Simplex Virus -1 Reactivation After Treatment With Dexamethasone and Sarilumab for Covid-19 Disease
CONCLUSIONS: HSV-1 reactivation is common in COVID-19 and likely contributes to poorer clinical outcomes. The mechanism causing susceptibility to viral reactivation is not clearly defined, however, the development of critical illness induced immunosuppression via dysfunction of interferon and interleukin pathways is a likely mechanism. This effect could be perpetuated with immunosuppressant medications, although further research is needed to characterise this phenomenon.PMID:37593250 | PMC:PMC10429616 | DOI:10.2478/jccm-2023-0010
Source: Herpes - August 18, 2023 Category: Infectious Diseases Authors: Thomas Roe Sam Waddy Nikitas Nikitas Source Type: research

Antiviral and Anti-Inflammatory Therapeutic Interventions for Treating Herpes Stromal Keratitis: A Systematic Review
CONCLUSION: Corticosteroids and antivirals managed HSK most effectively only when used concurrently. Oral acyclovir showed similar effectiveness to its ointment counterpart, a preferable alternative for easier administration. Corticosteroid use could induce greater therapeutic benefits when tapered in concentration and frequency and administrated for at least 10 weeks. Anti-inflammatory drugs including flurbiprofen, cyclosporine-A, and tacrolimus could be safe and effective for treating HSK. Future long-term follow-up and RCTs could provide insights on the therapeutic benefits of these potential alternatives.PMID:37184084 ...
Source: Herpes - May 15, 2023 Category: Infectious Diseases Authors: Xiaole Li Manav Nayeni Monali S Malvankar-Mehta Source Type: research

An Unusual Case of Hemophagocytic Lymphohistiocytosis Associated with < em > Mycobacterium chimaera < /em > or Large-Cell Neuroendocrine Carcinoma
We present a 56-year-old patient who was admitted with worsening weakness, exertional dyspnea, dry and nonproductive cough, and a 5-pound weight loss associated with loss of appetite. This is among the rare disorders that are not commonly encountered in day-to-day practice. Our differential diagnoses were broad, including infection, such as visceral leishmaniasis, atypical/tuberculous mycobacteria, histoplasmosis, Ehrlichia, Bartonella, Brucella, Adenovirus, disseminated herpes simplex virus (HSV), hematological-like Langerhans cell histiocytosis, or multicentric Castleman disease; drug reaction, such as drug rash with eos...
Source: Herpes - March 28, 2023 Category: Infectious Diseases Authors: Tejaswi Venigalla Sheila Kalathil Meena Bansal Mark Morginstin Vinicius Jorge Patricia Perosio Source Type: research

Postpartum Neonatal Disseminated Herpes Simplex Virus-1 Infection in Which Herpes Simplex Virus-1 Was Detected in Mother's Breast Milk
Indian J Pediatr. 2023 Jan 25. doi: 10.1007/s12098-022-04462-z. Online ahead of print.ABSTRACTA 17-d-old girl was diagnosed with disseminated herpes simplex virus-1 infection-associated hemophagocytic lymphohistiocytosis. The virus was detected in the neonate's blood and mandible. The neonate was treated with dexamethasone and acyclovir and discharged without neurological sequelae. The mother had no history of a herpes simplex virus-1 infection and did not have visible genital herpetic lesions; moreover, the neonate was delivered via an elective cesarean section. However, the day before the delivery, the mother had met wit...
Source: Herpes - January 25, 2023 Category: Infectious Diseases Authors: Yuhi Takagi Yuji Fujita Tomohiro Otaka Yuji Kano Keitaro Fukushima Yuya Sato Shigemi Yoshihara Source Type: research

Antibodies to varicella-zoster virus and three other herpesviruses and survival in adults with glioma
CONCLUSIONS: Low levels of VZV or EBV antibodies are associated with poorer survival outcomes for adults with glioma. Differential immune response rather than viral exposure may explain these findings.PMID:36610073 | DOI:10.1093/neuonc/noac283
Source: Herpes - January 7, 2023 Category: Infectious Diseases Authors: Geno Guerra Lucie McCoy Helen M Hansen Terri Rice Annette M Molinaro Joseph L Wiemels John K Wiencke Margaret Wrensch Stephen S Francis Source Type: research

Myoclonus status revealing COVID 19 infection
DISCUSSION: Our patient presented with acute isolated multifocal myoclonus status without cognitive impairment. These movements were prominent, spontaneous, worsened by action, and sensitive to touch and sound. The anatomical source of this myoclonus could be cortical or subcortical despite the absence of evident EEG discharges. Several diseases can cause acute myoclonus such as severe hypoxia, metabolic disturbances, and paraneoplastic syndromes. these diagnoses were ruled out in our patient. Post-vaccinal origin was also suggested, but its accountability was not proven. Thus, the two hypothetic etiologies raised were eit...
Source: Herpes - November 29, 2022 Category: Infectious Diseases Authors: Dina Ben Mohamed Rania Zouari Jihen Ketata Fatma Nabli Samir Blel Samia Ben Sassi Source Type: research

A Case Report: Clinical Efficacy of Combination Treatment of Dexamethasone and Azathioprine in Recurrent Erythema Multiforme
We reported a case of REM in a 49-year-old male. There were complaints of burning sensations on the skin lesions, along with swelling on both hands. On physical examination, erythematous macules and targetoid lesions were found on both palms, arms, and legs. During hospitalization, dexamethasone 20 mg was administered in a tapering dose but new skin lesions still appeared. Two days after azathioprine 50 mg twice daily was added to the treatment, skin lesions and swelling on the patient's hands were diminished and the burning sensation disappeared. No side effects of azathioprine were found in this patient and no recurrence...
Source: Herpes - July 14, 2022 Category: Infectious Diseases Authors: Oki Suwarsa Isabella Puspa Dewi Endang Sutedja Hartati Purbo Dharmadji Hendra Gunawan Miranti Pangastuti Source Type: research

Independent Cis-Regulatory Modules within the Herpes Simplex Virus 1 Infected Cell Protein 0 (ICP0) Promoter Are Transactivated by Kr üppel-like Factor 15 and Glucocorticoid Receptor
Viruses. 2022 Jun 13;14(6):1284. doi: 10.3390/v14061284.ABSTRACTA corticosteroid antagonist impairs Herpes Simplex Virus 1 (HSV-1) productive infection and explant-induced reactivation from latency, suggesting corticosteroids and the glucocorticoid receptor (GR) mediate certain aspects of these complex virus-host interactions. GR-hormone complexes regulate transcription positively and negatively, in part, by binding GR response elements (GREs). Recent studies revealed infected cell protein 0 (ICP0), ICP4, and ICP27 promoter/cis-regulatory modules (CRMs) are cooperatively transactivated by GR and Krüppel-like factor 15 (KL...
Source: Herpes - June 24, 2022 Category: Infectious Diseases Authors: Nishani Wijesekera Nicholas Hazell Clinton Jones Source Type: research

Risk factors for Herpes simplex virus (HSV) and Cytomegalovirus (CMV) infections in critically-ill COVID-19 patients
CONCLUSIONS: Our study shows a high prevalence of HSV-infection in critically-ill COVID-19 patients which was unexpectedly higher than the prevalence of CMV-infections and unrelated to dexamethasone treatment. The main risk factors for HSV and CMV in the studied cohorts were the length of ICU stay and duration of mechanical ventilation. Therefore, we recommend routine monitoring of critically ill COVID-19 patients for these viral co-infections and consider treatment in those patients.PMID:35340709 | PMC:PMC8941339 | DOI:10.4081/mrm.2022.815
Source: Herpes - March 28, 2022 Category: Infectious Diseases Authors: Kristina E Fuest Johanna Erber Wiebke Berg-Johnson Markus Heim Dieter Hoffmann Barbara Kapfer Silja Kriescher Bernhard Ulm Roland M Schmid Sebastian Rasch Tobias Lahmer Source Type: research

Risk factors for < em > Herpes simplex < /em > virus (HSV) and < em > Cytomegalovirus < /em > (CMV) infections in critically-ill COVID-19 patients
CONCLUSIONS: Our study shows a high prevalence of HSV-infection in critically-ill COVID-19 patients which was unexpectedly higher than the prevalence of CMV-infections and unrelated to dexamethasone treatment. The main risk factors for HSV and CMV in the studied cohorts were the length of ICU stay and duration of mechanical ventilation. Therefore, we recommend routine monitoring of critically ill COVID-19 patients for these viral co-infections and consider treatment in those patients.PMID:35340709 | PMC:PMC8941339 | DOI:10.4081/mrm.2022.815
Source: Respiratory Care - March 28, 2022 Category: Respiratory Medicine Authors: Kristina E Fuest Johanna Erber Wiebke Berg-Johnson Markus Heim Dieter Hoffmann Barbara Kapfer Silja Kriescher Bernhard Ulm Roland M Schmid Sebastian Rasch Tobias Lahmer Source Type: research

Risk factors for Herpes simplex virus (HSV) and Cytomegalovirus (CMV) infections in critically-ill COVID-19 patients
CONCLUSIONS: Our study shows a high prevalence of HSV-infection in critically-ill COVID-19 patients which was unexpectedly higher than the prevalence of CMV-infections and unrelated to dexamethasone treatment. The main risk factors for HSV and CMV in the studied cohorts were the length of ICU stay and duration of mechanical ventilation. Therefore, we recommend routine monitoring of critically ill COVID-19 patients for these viral co-infections and consider treatment in those patients.PMID:35340709 | PMC:PMC8941339 | DOI:10.4081/mrm.2022.815
Source: Herpes - March 28, 2022 Category: Infectious Diseases Authors: Kristina E Fuest Johanna Erber Wiebke Berg-Johnson Markus Heim Dieter Hoffmann Barbara Kapfer Silja Kriescher Bernhard Ulm Roland M Schmid Sebastian Rasch Tobias Lahmer Source Type: research

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