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TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1
This study was carried out in accordance with National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978) and approved by the Animal Ethics Committee of Zhejiang Chinese Medical University. Author Contributions QH performed the western blot, immunostaining, and behavioral test. QW performed the patch clamp experiments. CW supervised the patch clamp experiments. QH and BoyuL performed the behavioral test. YT, XS, and JF analyzed the data and reviewed the manuscript. BoyiL designed, supervised the study, and wrote the manuscript. Funding This project was suppor...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Intensive combination treatment regimens, including prednisolone, are effective in treating patients with early rheumatoid arthritis regardless of additional etanercept: 1-year results of the COBRA-light open-label, randomised, non-inferiority trial
Conclusions Intensive COBRA or COBRA-light therapy has major, comparably favourable effects on disease activity, functional ability and radiological outcome after 1 year in patients with early RA. Protocolised addition of etanercept was often not implemented by treating rheumatologists, and patients receiving it appeared to have limited added benefit, probably because of low disease activity levels at its initiation. Trial registration number: ISRCTN55552928.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: ter Wee, M. M., den Uyl, D., Boers, M., Kerstens, P., Nurmohamed, M., van Schaardenburg, D., Voskuyl, A. E., Lems, W. F. Tags: Immunology (including allergy), Physiotherapy, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Trends in the first decade of 21st century healthcare utilisation in a rheumatoid arthritis cohort compared with the general population
Conclusions During the first decade of the 21st century, coinciding with increasing use of earlier and more active RA treatment including biological treatment, overall inpatient and outpatient healthcare utilisation by a cohort of patients with RA decreased relative to the general population.
Source: Annals of the Rheumatic Diseases - May 30, 2013 Category: Rheumatology Authors: Hagel, S., Petersson, I. F., Bremander, A., Lindqvist, E., Bergknut, C., Englund, M. Tags: Editor's choice, Immunology (including allergy), Physiotherapy, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Physiotherapy, Epidemiology Clinical and epidemiological research Source Type: research