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Prevention of conversion to abnormal tcd with hydroxyurea in sickle cell anemia: A phase III international randomized clinical trial
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - September 28, 2015 Category: Hematology Authors: Jane S. Hankins, M. Beth McCarville, Angela Rankine‐Mullings, Marvin E. Reid, Clarisse L.C. Lobo, Patricia G. Moura, Susanna Ali, Deanne Soares, Karen Aldred, Dennis W. Jay, Banu Aygun, John Bennett, Guolian Kang, Jonathan C. Goldsmith, Matthew P. Smelt Tags: Research Article Source Type: research

Prevention of conversion to abnormal transcranial Doppler with hydroxyurea in sickle cell anemia: A Phase III international randomized clinical trial
Children with sickle cell anemia (SCA) and conditional transcranial Doppler (TCD) ultrasound velocities (170–199 cm/sec) may develop stroke. However, with limited available clinical data, the current standard of care for conditional TCD velocities is observation. The efficacy of hydroxyurea in preventing conversion from conditional to abnormal TCD (≥200 cm/sec), which confers a higher stroke risk, has not been studied prospectively in a randomized trial. Sparing Conversion to Abnormal TCD Elevation (SCATE #NCT01531387) was a National Heart, Lung, and Blood Institute‐funded Phase III multicenter international clinical...
Source: American Journal of Hematology - November 17, 2015 Category: Hematology Authors: Jane S. Hankins, Mary Beth McCarville, Angela Rankine‐Mullings, Marvin E. Reid, Clarisse L.C. Lobo, Patricia G. Moura, Susanna Ali, Deanne P. Soares, Karen Aldred, Dennis W. Jay, Banu Aygun, John Bennett, Guolian Kang, Jonathan C. Goldsmith, Matthew P. Tags: Research Article Source Type: research

A case report of adult lead toxicity following use of Ayurvedic herbal medication
DiscussionA high index of suspicion of metal toxicity is necessary among persons with characteristic symptoms and signs in the absence of occupational exposure. Despite limited evidence for chelation in adults and in those with modest blood lead levels, this patient appeared to benefit from repeated chelation therapy. Both allopathic and alternative medicine practitioners and public health specialists need to be aware of the potential for contamination of and side effects from alternative pharmacologic and herbal therapies.
Source: Journal of Occupational Medicine and Toxicology - October 2, 2013 Category: Occupational Health Authors: Laura BreeherFred GerrLaurence Fuortes Source Type: research

Contemporary Procedural Trends of Watchman Percutaneous Left Atrial Appendage Occlusion in the United States
ConclusionIn contemporary United States clinical practice, Watchman utilization has increased significantly since approval in 2015, while complications and in ‐patient mortality have declined.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - November 5, 2020 Category: Cardiology Authors: Muhammad Bilal Munir, Muhammad Zia Khan, Douglas Darden, Deepak Kumar Pasupula, Sudarshan Balla, Frederick T. Han, Ryan Reeves, Jonathan C. Hsu Tags: ORIGINAL ARTICLES Source Type: research

Contemporary procedural trends of Watchman percutaneous left atrial appendage occlusion in the United States
ConclusionIn contemporary United States clinical practice, Watchman utilization has increased significantly since approval in 2015, while complications and in ‐patient mortality have declined.
Source: Journal of Cardiovascular Electrophysiology - November 11, 2020 Category: Cardiology Authors: Muhammad Bilal Munir, Muhammad Zia Khan, Douglas Darden, Deepak K. Pasupula, Sudarshan Balla, Frederick T. Han, Ryan Reeves, Jonathan C. Hsu Tags: ORIGINAL ARTICLES Source Type: research

Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound
The dried rhizome of Ligusticum sinense Oliv.cv. Chaxiong has been used to treat cardiovascular and cerebrovascular diseases, atherosclerosis, anemia and stroke. A high purity extract from chaxiong (VOC, brownish...
Source: BMC Complementary and Alternative Medicine - April 22, 2021 Category: Complementary Medicine Authors: Peng-yi Hu, Ying-huai Zhong, Jian-fang Feng, Dong-xun Li, Ping Deng, Wen-liu Zhang, Zhi-qiang Lei, Xue-mei Liu and Guo-song Zhang Tags: Research article Source Type: research