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FDA OKs First Treatment for Chronic Rhinosinusitis With Polyps FDA OKs First Treatment for Chronic Rhinosinusitis With Polyps
Dupilumab is the first treatment approved for inadequately controlled chronic rhinosinusitis with nasal polyps.FDA Approvals
Source: Medscape Med Students Headlines - June 26, 2019 Category: Universities & Medical Training Tags: Allergy & Clinical Immunology News Alert Source Type: news

Interleukin ‐4‒induced posttranscriptional gene regulation of CCL26 by the RNA‐binding protein HuR in primary human nasal polyp‒derived epithelial cells
ConclusionOur results provide strong support for the hypothesis that IL ‐4‒induced expression of CCL26 in hNPDECs relies partly on CCL26 mRNA stabilization mediated by the interaction of HuR with CCL26 3'UTR.
Source: International Forum of Allergy and Rhinology - November 24, 2018 Category: Allergy & Immunology Authors: Peng Tian, Huashuang Ou, Fan Wu, Yun Ma, Xiang Liu, Qiujian Chen, Hua Dang, Hua Zou Tags: ORIGINAL ARTICLE Source Type: research

Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps.
CONCLUSION: Our proteomic analysis confirmed that the coagulation pathway is highly significantly deranged within nasal polyp tissue. The correlation between tissue- and mucus-derived exosomal fibrinolysis and coagulation protein alterations were strong, inverse, and highly significant. This lends further support to the emerging concept of exosomal proteomic analysis as a method to study chronic sinonasal inflammation. PMID: 30091854 [PubMed - as supplied by publisher]
Source: Genomics Proteomics ... - August 9, 2018 Category: Genetics & Stem Cells Authors: Mueller SK, Nocera AL, Dillon ST, Wu D, Libermann TA, Bleier BS Tags: Int Forum Allergy Rhinol Source Type: research

P‐glycoprotein regulates Staphylococcus aureus enterotoxin B–stimulated interleukin‐5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants
ConclusionP‐gp protein is expressed at higher concentrations in CRSwNP as compared to CRS. This overexpression directly contributes to the relative hypersecretion of IL‐5 and TSLP. These findings suggest a novel mechanism for Th2 skewing in CRSwNP.
Source: International Forum of Allergy and Rhinology - November 1, 2015 Category: Allergy & Immunology Authors: Benjamin S. Bleier, Amy Singleton, Angela L. Nocera, Armine Kocharyan, Victoria Petkova, Xue Han Tags: ORIGINAL ARTICLE Source Type: research

Verapamil modulates interleukin‐5 and interleukin‐6 secretion in organotypic human sinonasal polyp explants
ConclusionAlthough the mechanism has yet to be fully understood, L‐type CCBs are capable of reducing inflammation in multiple tissues. Verapamil was specifically found to reduce airway goblet cell hyperplasia and eosinophilic infiltration in a murine asthma model. Our data support these findings suggesting that verapamil can modulate T‐helper cell type 2 (Th2)‐associated cytokine secretion in sinonasal polyp explants. This data points to a possible therapeutic role for CCBs in the management of CRSwNP.
Source: International Forum of Allergy and Rhinology - October 1, 2014 Category: Allergy & Immunology Authors: Benjamin S. Bleier, Armine Kocharyan, Amy Singleton, Xue Han Tags: ORIGINAL ARTICLE Source Type: research

Aspirin sensitivity does not compromise quality‐of‐life outcomes in patients with samter's triad
ConclusionsAlthough Samter's triad patients present with more severe disease and are more likely to undergo revision surgery, they have postoperative quality‐of‐life outcomes that are comparable to patients with eCRSwP who are not aspirin sensitive. This is the first study to utilize a disease‐specific, validated outcomes instrument in comparing Samter's triad patients with aspirin‐tolerant patients who have nasal polyposis and tissue eosinophilia. Level of Evidence4. Laryngoscope, 2013
Source: The Laryngoscope - June 28, 2013 Category: ENT & OMF Authors: David W. Jang, Brett T. Comer, Vasileios A. Lachanas, Stilianos E. Kountakis Tags: Allergy/Rhinology Source Type: research

Aspirin sensitivity does not compromise quality of life outcomes in patients with Samter's triad
ConclusionAlthough Samter's triad patients present with more severe disease and are more likely to undergo revision surgery, they have postoperative quality‐of‐life outcomes that are comparable to patients with eCRSwP who are not aspirin sensitive. This is the first study to utilize a disease‐specific, validated outcomes instrument in comparing Samter's triad patients with aspirin tolerant patients who have nasal polyposis and tissue eosinophilia.
Source: The Laryngoscope - May 27, 2013 Category: ENT & OMF Authors: David W. Jang, Brett T. Comer, Vasileios Lachanas, Stilianos E. Kountakis Tags: Allergy/Rhinology Source Type: research