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Efficacy and safety of rivaroxaban compared with warfarin in patients with peripheral artery disease and non-valvular atrial fibrillation: insights from ROCKET AF
Conclusion Patients with PAD in ROCKET AF did not have a statistically significant higher risk of stroke or systemic embolism than patients without PAD, and there were similar efficacy outcomes in patients treated with rivaroxaban and warfarin. In PAD patients, there was a higher risk of major bleeding or NMCR bleeding with rivaroxaban when compared with warfarin (interaction P = 0.037). Further investigation is warranted to validate this subgroup analysis and determine the optimal treatment in this high-risk cohort of AF patients with PAD.
Source: European Heart Journal - January 21, 2014 Category: Cardiology Authors: Jones, W. S., Hellkamp, A. S., Halperin, J., Piccini, J. P., Breithardt, G., Singer, D. E., Fox, K. A. A., Hankey, G. J., Mahaffey, K. W., Califf, R. M., Patel, M. R. Tags: Atrial fibrillation Source Type: research

Gender difference in long-term prognosis among patients with cardiovascular disease
Conclusion: Women with cardiovascular disease who received a similar standardized cardiovascular work-up and personalized therapy advice as men had a favourable long-term outcome.
Source: European Journal of Preventive Cardiology - December 16, 2013 Category: Cardiology Authors: van der Meer, M. G., Cramer, M. J., van der Graaf, Y., Doevendans, P. A., Nathoe, H. M., (on behalf of the SMART study group) Tags: Original scientific papers Source Type: research

Trends in abdominal aortic aneurysm prevalence and mortality in non-European countries
After 3 decades of epidemiologic research on abdominal aortic aneurysm (AAA), prevalence and mortality rates from AAA in England and Scandinavian countries have been shown to be decreasing , raising the question about what the trends of prevalence and mortality rates from AAA in non-European countries are. With that aim, we conducted a literature search for observational studies and randomized controlled trials that assessed prevalence and mortality rates in non-European populations published since January 1983 till June 2013 in MEDLINE, EMBASE and LILACS electronic databases. The search strategy was [abdominal aortic aneu...
Source: International Journal of Cardiology - November 8, 2013 Category: Cardiology Authors: Jerson Munoz-Mendoza, Veronica A. Pinto Miranda, Henry C. Quevedo, Kathy Hebert Tags: Online letters to the editor Source Type: research

The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk
Conclusions These findings suggest that CAD/MI-associated risk alleles play an aetiological role in different types of atherosclerotic disease.
Source: European Heart Journal - October 1, 2013 Category: Cardiology Authors: Tragante, V., Doevendans, P. A. F. M., Nathoe, H. M., van der Graaf, Y., Spiering, W., Algra, A., de Borst, G. J., de Bakker, P. I. W., Asselbergs, F. W., on behalf of the SMART study group Tags: Coronary artery disease Source Type: research

Impact of Inherited Genetic Variants Associated With Lipid Profile, Hypertension, and Coronary Artery Disease on the Risk of Intracranial and Abdominal Aortic Aneurysms Original Articles
Conclusions— We demonstrate that genetic risk profiles of lipid factors and CAD are associated with AAAs but not with IAs, and the genetic risk profile of blood pressure is associated with IAs but not with AAAs. These findings are consistent with epidemiological observations.
Source: Circulation: Cardiovascular Genetics - June 18, 2013 Category: Cardiology Authors: van 't Hof, F. N. G., Ruigrok, Y. M., Baas, A. F., Kiemeney, L. A. L. M., Vermeulen, S. H., Uitterlinden, A. G., Hofman, A., Rivadeneira, F., Rinkel, G. J. E., de Bakker, P. I. W. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Genetics of Stroke Original Articles Source Type: research

The risk of resting heart rate on vascular events and mortality in vascular patients
Conclusions: Elevated RHR is associated with increased risk for mortality but not for myocardial infarction or stroke in patients with manifest vascular diseases irrespective of location of vascular disease.
Source: International Journal of Cardiology - January 10, 2013 Category: Cardiology Authors: Remy H.H. Bemelmans, Yolanda van der Graaf, Hendrik M. Nathoe, Annemarie M.J. Wassink, Joris W.P. Vernooij, Wilko Spiering, Frank L.J. Visseren, on behalf of the SMART study group Tags: Original Articles Source Type: research

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