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MiR-342-5p protects neurons from cerebral ischemia induced-apoptosis through regulation of Akt/NF- κB pathways by targeting CCAR2
Ischemic stroke causes high morbidity, mortality and health burden in the world. MiR-342-5p was associated with Alzheimer's disease and cardio-protection. Herein, we aimed to reveal effects of miR-342-5p on cerebral ischemia injury as well as novel targets for stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 23, 2022 Category: Neurology Authors: Haochun Zhu, Yanhua Zhang, Yanling Zhu Source Type: research

Associations between primary care electrocardiography and non-Alzheimer dementia
To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2022 Category: Neurology Authors: Jonas L. Isaksen, Jonas Ghouse, Morten W. Skov, Morten S. Olesen, Anders G. Holst, Adrian Pietersen, Jonas B. Nielsen, Anja Maier, Claus Graff, Ruth Frikke-Schmidt, J ørgen K. Kanters Source Type: research

Volumetric White Matter Hyperintensity Ranges Correspond to Fazekas Scores on Brain MRI
Leukoaraiosis presents as white matter hyperintensities (WMH) on magnetic resonance (MR) imaging. It is thought to originate from decreased vascular supply to axons with an accompanying loss of axonal integrity. WMH have been found to be more prevalent in older patients, especially in those with neurodegeneration from Alzheimer's disease (AD) or stroke.1-6A visual categorization method named the Fazekas scale was developed in order to compare white matter disease burden on computed tomography scans between patients experiencing normal aging and those with AD.
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2022 Category: Neurology Authors: Ariana Andere, Gaurav Jindal, Janine Molino, Scott Collins, Derek Merck, Tina Burton, Christoph Stretz, Shadi Yaghi, Daniel C. Sacchetti, Sleiman El Jamal, Michael E. Reznik, Karen Furie, Shawna Cutting Tags: Short Communication Source Type: research

Association Between Small Vessel Disease Markers, Medial Temporal Lobe Atrophy and Cognitive Impairment After Stroke: A Systematic Review and Meta-Analysis
Two-thirds of stroke survivors suffer from cognitive impairment, and up to one-third of them progress to dementia. However, the underlying pathogenesis is complex and controversial. Recent evidence has found that cerebral small vessel disease (SVD) markers and the Alzheimer's disease (AD) neuroimaging marker medial temporal lobe atrophy (MTLA), alone or in combination, contribute to the pathogenesis of poststroke cognitive impairment (PSCI). In the present systematic review and meta-analysis, we synthesized proof for these neuroimaging risk factors among stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - November 20, 2020 Category: Neurology Authors: Furu Wang, Sunyu Hua, Yue Zhang, Hongchang Yu, Zhongshuai Zhang, Jiangtao Zhu, Rong Liu, Zhen Jiang Source Type: research

The association of rs2233679 in the PIN1 gene promoter with the risk of Coronary Artery Disease in Chinese female individuals
Cerebral vascular dysfunction is associated with various neurological disorders, which often share some common mechanisms with cardiovascular diseases especially Coronary Artery Disease (CAD).1 –6 Pin1 (encoded by the PIN1 gene) is a key enzyme in humans and is implicated in Alzheimer disease by suppressing amyloid–β deposition and tau aggregation.7–11 Recently, we hypothesized that Pin1 may cause cerebrovascular atherosclerosis and aggravate ischemia-related neurological disorders. 12 However, the relationship between the genetic polymorphisms of PIN1 and vascular atherosclerosis in humans is still not clear.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jing-Zhang Wang, Wen-Tao Du, Jing Bai, Shu-Zhen Cheng, Yu-Hua Zhang Source Type: research

Mesial Frontal Lobe Infarction Presenting as Pisa Syndrome
Pisa syndrome is usually seen in patients with Alzheimer's disease treated with a cholinesterase inhibitor, dementia with Lewy bodies, Parkinson's disease, or atypical parkinsonism including multiple system atrophy. An 86-year-old woman presented with an acute onset of lateral flexion of her trunk to the left side, i.e., Pisa syndrome. She also showed left hemiparesis predominantly in her lower extremity. Her diffusion-weighted magnetic resonance images showed acute infarction in the right premotor area and supplementary motor area.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Kazuyuki Noda, Maya Ando, Takayuki Jo, Anri Hattori, Kotaro Ogaki, Mizuho Sugiyama, Nobutaka Hattori, Yasuyuki Okuma Tags: Case Report Source Type: research

Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion
Background: The pathological impact of chronic cerebral hypoperfusion (CCH) on Alzheimer's disease (AD) is still poorly understood. In the present study, we investigated the role of CCH on an AD mouse model in phosphorylated tau and α-synuclein pathology, neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of a new antioxidant Twendee X (TwX). Methods: APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors to gradual ly decrease the cerebral blood flow.
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2019 Category: Neurology Authors: Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion
Multiple pathogeneses are involved in Alzheimer's disease (AD), such as amyloid- β accumulation, neuroinflammation, and oxidative stress. The pathological impact of chronic cerebral hypoperfusion on Alzheimer's disease is still poorly understood.
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2019 Category: Neurology Authors: Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

C-Reactive Protein Can Be an Early Predictor of Poststroke Apathy in Acute Ischemic Stroke Patients
Apathy is a multidimensional syndrome referring to a primary lack of motivation that occurs frequently in survivors of stroke. Higher C-reactive protein (CRP) level was associated with higher apathy scores among Alzheimer disease cases. However, data on the relationship between CRP levels and apathy in patients with stroke are lacking. So, we hypothesized an association between CRP and poststroke apathy (PSA).
Source: Journal of Stroke and Cerebrovascular Diseases - March 13, 2018 Category: Neurology Authors: Liping Chen, Siqing Xiong, Yi Liu, Meiqing Lin, Jirui Wang, Renjia Zhong, Jiuhan Zhao, Wenjing Liu, Lu Zhu, Xiuli Shang Source Type: research

Qualitative Analysis of Mini Mental State Examination Pentagon in Vascular Dementia and Alzheimer's Disease: A Longitudinal Explorative Study
Vascular dementia and Alzheimer's disease are the most diffuse forms of dementia. Sometimes, they are difficult to distinguish due to overlaps in symptomatology, pathophysiology, and comorbidity. Visual constructive apraxia is very common in dementia and impairment in these abilities can provide clinical information for differential diagnosis.
Source: Journal of Stroke and Cerebrovascular Diseases - March 1, 2018 Category: Neurology Authors: Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Maria Foti, Rosanna Palmeri, Marra Angela, Giuseppe Di Lorenzo, Antonino Todaro, Placido Bramanti, Alessia Bramanti, Silvia Marino Source Type: research

Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model
Dementia is the most prevalent neurological disease in aged people. Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD). However, effective therapy for those two diseases is still missing. Resveratrol is a polyphenol produced by plants that have multiple biological functions, such as increased life span and delay in the onset of diseases associated with aging. It is known supplement with resveratrol could exert neuroprotection against multiple injury factors induced neuronal death and degeneration, as well as the cognitive decline of CCH rat model.
Source: Journal of Stroke and Cerebrovascular Diseases - October 8, 2015 Category: Neurology Authors: Huagang Li, Jing Wang, Pu Wang, Yan Rao, Liping Chen Source Type: research

Cognitive Correlates of Cerebral Vasoreactivity on Transcranial Doppler in Older Adults
This study was performed to explore the possible contributions of cerebral hemodynamic changes to the cognitive impairment in patients with Alzheimer's disease (AD).
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: YongSoo Shim, Bora Yoon, Dong Suk Shim, Woojun Kim, Jae-Young An, Dong-Won Yang Source Type: research

Strong Reduction of Low-Density Lipoprotein Receptor/Apolipoprotein E Expressions by Telmisartan in Cerebral Cortex and Hippocampus of Stroke Resistant Spontaneously Hypertensive Rats
Conclusions: These findings suggest that a long-term treatment with telmisartan directly improved neuronal lipid metabolism in the cerebral cortex and hippocampus of SHR-SR, mainly improving LDL-R and ApoE metabolism (SHR/Low) with a small additive benefit by BP lowering (SHR/High), which could provide a preventative approach in patients with hypertension at risk of Alzheimer disease.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2014 Category: Neurology Authors: Yun Zhai, Toru Yamashita, Tomoko Kurata, Yusuke Fukui, Kota Sato, Syoichiro Kono, Wentao Liu, Yoshio Omote, Nozomi Hishikawa, Kentaro Deguchi, Koji Abe Tags: Original Articles Source Type: research

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