Filtered By:
Specialty: Neurology
Source: Stroke
Condition: Alzheimer's

This page shows you your search results in order of date.

Order by Relevance | Date

Total 20 results found since Jan 2013.

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia Clinical Sciences
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Neuroimaging Correlates of Cerebral Microbleeds Clinical Sciences
Conclusions—CMBs are a common vascular pathology in the elderly. Markers of hypertensive small-vessel disease may contribute to deep CMBs while cerebral amyloid angiopathy may drive development of lobar CMBs.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Jonathan Graff-Radford, Jeannette Simino, Kejal Kantarci, Thomas H. Mosley Jr, Michael E. Griswold, B. Gwen Windham, A. Richey Sharrett, Marilyn S. Albert, Rebecca F. Gottesman, Clifford R. Jack Jr, Prashanthi Vemuri, David S. Knopman Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Atherosclerosis Original Contributions Source Type: research

Ultrasound Markers of Carotid Atherosclerosis and Cognition Clinical Sciences
Conclusions—Subclinical carotid atherosclerosis was associated with worse cognition among those at higher risk for Alzheimer disease. Interventions targeting early stages of atherosclerosis may modify cognitive aging.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Hannah Gardener, Michelle R. Caunca, Chuanhui Dong, Ying Kuen Cheung, Mitchell S.V. Elkind, Ralph L. Sacco, Tatjana Rundek, Clinton B. Wright Tags: Ultrasound, Cognitive Impairment, Atherosclerosis Original Contributions Source Type: research

Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia Clinical Sciences
Conclusions— Aortic stiffness was an independent predictor of incident mild cognitive impairment in the whole sample and with incident dementia in nondiabetic patients. Our findings suggest aortic stiffness as a potentially modifiable risk factor for clinical cognitive impairment and dementia.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Pase, M. P., Beiser, A., Himali, J. J., Tsao, C., Satizabal, C. L., Vasan, R. S., Seshadri, S., Mitchell, G. F. Tags: Epidemiology, Vascular Disease Clinical Sciences Source Type: research

Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment Clinical Sciences
Conclusions— Mild cognitive impairment is very prevalent in CAA. The overall cognitive profile of CAA is more similar to that seen in vascular cognitive impairment rather than Alzheimer’s disease. White matter ischemic lesions may underlie some of the impaired processing speed in CAA.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Case, N. F., Charlton, A., Zwiers, A., Batool, S., McCreary, C. R., Hogan, D. B., Ismail, Z., Zerna, C., Coutts, S. B., Frayne, R., Goodyear, B., Haffenden, A., Smith, E. E. Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Intracranial Hemorrhage Clinical Sciences Source Type: research

Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia Clinical Sciences
Conclusions— Adherence to the American Heart Association’s ideal CVH factors and behaviors, particularly in midlife, may protect against cerebrovascular disease and dementia.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Pase, M. P., Beiser, A., Enserro, D., Xanthakis, V., Aparicio, H., Satizabal, C. L., Himali, J. J., Kase, C. S., Vasan, R. S., DeCarli, C., Seshadri, S. Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Cognitive Impairment Clinical Sciences Source Type: research

Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study Clinical Sciences
Conclusions— Among young healthy adults, higher aortic stiffness was associated with measures of reduced white matter and GM integrity in areas implicated in cognitive decline and Alzheimer’s disease. Greater aortic stiffness may result in subclinical vascular brain injury at ages much younger than previously described.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Maillard, P., Mitchell, G. F., Himali, J. J., Beiser, A., Tsao, C. W., Pase, M. P., Satizabal, C. L., Vasan, R. S., Seshadri, S., DeCarli, C. Tags: Aging, High Blood Pressure, Magnetic Resonance Imaging (MRI) Clinical Sciences Source Type: research

Role of Vascular Disease in Alzheimer-Like Progressive Cognitive Impairment Controversies in Stroke
Source: Stroke - January 25, 2016 Category: Neurology Authors: Viswanathan, A., Greenberg, S. M., Scheltens, P. Tags: Cognitive Impairment Controversies in Stroke Source Type: research

Positron Emission Tomographic Imaging in Stroke: Cross-Sectional and Follow-Up Assessment of Amyloid in Ischemic Stroke Clinical Sciences
Conclusions— There was no significant increase in 11C-PiB accumulation in or around the infarct. There was no increase in ipsilesional hemispheric 11C-PiB accumulation over time. We found no evidence that infarction leads to sustained or increased β-amyloid deposition ≤18 months after stroke.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Sahathevan, R., Linden, T., Villemagne, V. L., Churilov, L., Ly, J. V., Rowe, C., Donnan, G., Brodtmann, A. Tags: Nuclear Cardiology and PET, Cognitive Impairment, Ischemic Stroke Clinical Sciences Source Type: research

Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke Basic Sciences
Conclusions— These results support the idea that lipid raft integrity, ensured by seladin-1/DHCR24, plays a crucial protective role in the ischemic brain by guaranteeing EAAT2-mediated uptake of glutamate excess.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Hernandez-Jimenez, M., Martinez-Lopez, D., Gabande-Rodriguez, E., Martin-Segura, A., Lizasoain, I., Ledesma, M. D., Dotti, C. G., Moro, M. A. Tags: Cerebrovascular Disease/Stroke, Neuroprotectants Basic Sciences Source Type: research

Influence of Amyloid-{beta} on Cognitive Decline After Stroke/Transient Ischemic Attack: Three-Year Longitudinal Study Clinical Sciences
Conclusions— Compared with subjects without Alzheimer’s disease–like Aβ deposition, those with Aβ deposition experienced a more severe and rapid cognitive decline over 3 years after stroke/transient ischemic attack. Aβ was associated with changes in multiple cognitive domains.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Liu, W., Wong, A., Au, L., Yang, J., Wang, Z., Leung, E. Y. L., Chen, S., Ho, C. L., Mok, V. C. T. Tags: Behavioral Changes and Stroke, PET and SPECT Clinical Sciences Source Type: research

Multidomain Lifestyle Interventions for the Prevention of Cognitive Decline After Ischemic Stroke: Randomized Trial Clinical Sciences
Conclusions— This trial found no benefit of 24-month multidomain intervention with focus on improvement in lifestyle and vascular risk factors on the incidence of poststroke cognitive decline in comparison with standard stroke care. Studies with a larger sample size are needed. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique identifier: NCT01109836.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Matz, K., Teuschl, Y., Firlinger, B., Dachenhausen, A., Keindl, M., Seyfang, L., Tuomilehto, J., Brainin, M., on behalf of the ASPIS Study Group, Participants in the ASPIS Study Group in addition to the authors named, Schnider, Bancher, Pinter, Kepplinger Tags: Embolic stroke Clinical Sciences Source Type: research

Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities Clinical Sciences
Conclusions— Despite not passing multiple testing thresholds individually, these genes collectively are relevant to known WMH associations, proposed WMH mechanisms, or dementia: associations with Alzheimer's disease, late-life depression, ATP production, osmotic regulation, neurodevelopmental abnormalities, and cognitive impairment. If replicated further, they suggest a multifactorial nature for WMH and argue for more consideration of vascular contributions to dementia.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Lopez, L. M., Hill, W. D., Harris, S. E., Valdes Hernandez, M., Munoz Maniega, S., Bastin, M. E., Bailey, E., Smith, C., McBride, M., McClure, J., Graham, D., Dominiczak, A., Yang, Q., Fornage, M., Ikram, M. A., Debette, S., Launer, L., Bis, J. C., Schmid Tags: Other Vascular biology Clinical Sciences Source Type: research

Memantine Enhances Recovery From Stroke Basic Sciences
Conclusions— Our results suggest that memantine improves stroke outcomes in an apparently non-neuroprotective manner involving increased brain-derived neurotrophic factor signaling, reduced reactive astrogliosis, and improved vascularization, associated with improved recovery of sensory and motor cortical function. The clinical availability and tolerability of memantine make it an attractive candidate for clinical translation.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Lopez-Valdes, H. E., Clarkson, A. N., Ao, Y., Charles, A. C., Carmichael, S. T., Sofroniew, M. V., Brennan, K. C. Tags: Animal models of human disease, Imaging, Other imaging, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy Basic Sciences
Conclusions— Tg-SwDI mice exhibit a profound age-dependent cerebrovascular dysfunction, involving multiple regulatory mechanisms. Early in the disease process, oxidative stress is responsible for most of the vascular dysfunction, but with advancing disease structural alterations of the vasomotor apparatus also play a role. Early therapeutic interventions are likely to have the best chance to counteract the deleterious vascular effects of cerebral amyloid angiopathy.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Park, L., Koizumi, K., El Jamal, S., Zhou, P., Previti, M. L., Van Nostrand, W. E., Carlson, G., Iadecola, C. Tags: Animal models of human disease Basic Sciences Source Type: research