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VIP and PACAP: Neuropeptide modulators of CNS inflammation, injury, and repair
Summary page Inflammatory processes play both regenerative and destructive roles in multiple sclerosis, stroke, CNS trauma, amyotrophic lateral sclerosis (ALS) and aging‐related neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Endogenous defense mechanisms against these pathologies include those that are directly neuroprotective, and those that modulate the expression of inflammatory mediators in microglia, astrocytes, and invading inflammatory cells. While a number of mechanisms and molecules have been identified that can directly promote neuronal survival, less is known about how the brain...
Source: British Journal of Pharmacology - March 20, 2013 Category: Drugs & Pharmacology Authors: J A Waschek Tags: Review Article Source Type: research

Mitochondrial metals as a potential therapeutic target in neurodegeneration
Summary Transition metals are critical for enzyme function and protein folding, but in excess can mediate neurotoxic oxidative processes. As mitochondria are particularly vulnerable to oxidative damage due to radicals generated during ATP production, mitochondrial biometal homeostasis must therefore be tightly controlled to safely harness the redox potential of metal enzyme cofactors. Dysregulation of metal functions is evident in numerous neurological disorders including Alzheimer's disease, stroke, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedrich's Ataxia. This review describes the m...
Source: British Journal of Pharmacology - November 11, 2013 Category: Drugs & Pharmacology Authors: A Grubman, A R White, J R Liddell Tags: Review Article – Mitochondrial Pharmacology: Energy, Injury & Beyond Themed Issue Source Type: research

The Effects of Sigma‐1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice
Conclusions and ImplicationsThe sigma‐1 receptor selective compound such as LS‐1‐137 may represent a novel candidate cognitive enhancer for the treatment of cholinergic muscarinic‐dependent cognitive deficits.
Source: British Journal of Pharmacology - January 9, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H. Mach, Robert R. Luedtke Tags: Research Paper Source Type: research

The effects of sigma (σ1) receptor‐selective ligands on muscarinic receptor antagonist‐induced cognitive deficits in mice
Conclusions and ImplicationsThe σ1 receptor‐selective compound LS‐1–137 may represent a novel candidate cognitive enhancer for the treatment of muscarinic receptor‐dependent cognitive deficits.
Source: British Journal of Pharmacology - April 10, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H Mach, Robert R Luedtke Tags: RESEARCH PAPER Source Type: research

Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen‐glucose deprivation conditions, an in vitro experimental model of cerebral ischemia
CONCLUSIONS AND IMPLICATIONSThese results allow us to conclude that the multitarget compound DPH‐4 might provide a therapeutic benefit to delay the onset and/or progression of these two linked neurological pathologies. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - September 12, 2015 Category: Drugs & Pharmacology Authors: P Sun, G Esteban, T Inokuchi, J Marco‐Contelles, B B Weksler, I A Romero, P O Couraud, M Unzeta, M Solé Tags: RESEARCH PAPER Source Type: research