• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Oral antidiabetic drugs and dementia risk: Does treatment matter?
As the population ages, dementia grows as a public health problem. The rising life expectancy and the aging of the so-called baby boomer cohort translate to a substantial number of people reaching ages of high risk for age-related conditions like dementia. As a major cause of disability and dependency in elderly people, dementia puts social and economic burden on patients and their families and affects health care systems worldwide. In the absence of a cure, primary prevention will have the largest effect on the reduction of dementia occurrence.1 Thus, public health research should focus on the identification of modifiable...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Fink, A., Haenisch, B. Tags: All Cognitive Disorders/Dementia, All epidemiology EDITORIALS Source Type: research

Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy
Conclusions: These findings support the hypothesis that participants with PART have an amyloid-independent dementing Alzheimer disease–like temporal lobe tauopathy.
Source: Neurology - October 16, 2017 Category: Neurology Authors: Besser, L. M., Crary, J. F., Mock, C., Kukull, W. A. Tags: All Clinical Neurology, Prognosis, Depression, All Cognitive Disorders/Dementia, Cognitive aging ARTICLE Source Type: research

Hospital safety among neurologic patients: A population-based cohort study of adverse events
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Sauro, K. M., Quan, H., Sikdar, K. C., Faris, P., Jette, N. Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research

Cerebrovascular disease affects brain structural integrity long before clinically overt strokes
In the current issue of Neurology®, Werden et al.1 examined a group of patients experiencing first-ever or recurrent stroke to understand the relationships between stroke and cortical structural integrity. They performed 3T magnetic resonance scanning within 6 weeks of the most recent stroke and found that stroke patients had smaller hippocampal volumes and greater white matter hyperintensity (WMH) volume compared to controls. Because of the short time lag from stroke to scan, the authors do not believe that the index stroke itself caused the shrinkage in the hippocampus; rather, they believe that the stroke and the st...
Source: Neurology - July 10, 2017 Category: Neurology Authors: Knopman, D. S., Hooshmand, B. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia EDITORIALS Source Type: research

Structural MRI markers of brain aging early after ischemic stroke
Conclusions: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Werden, E., Cumming, T., Li, Q., Bird, L., Veldsman, M., Pardoe, H. R., Jackson, G., Donnan, G. A., Brodtmann, A. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia ARTICLE Source Type: research

The Clinical and Neuropathological Correlates of Second-Impact Syndrome: Case Report of a 17-year-old Female Rugby Player (P6.164)
Conclusions:This is the first case study to report the clinical and neuropathological features of SIS. Larger autopsy samples are needed to systematically identify clinicopathological correlates of SIS to facilitate research on risk factors and preventative strategies (e.g., return-to-play guidelines) to prevent unnecessary fatalities in young athletes.Study Supported by: This work was supported by the National Institute of Neurological Disorders and Stroke (1U01NS086659-01, U01NS093334, R01NS078337, R56NS078337), Department of Defense (W81XWH-13-2-0064), Department of Veterans Affairs, the Veterans Affairs Biorepository (...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mian, M., Alosco, M., Mez, J., Kiernan, P., Daneshvar, D., Nowinski, C., Kowall, N., Stern, R., Katz, D., Cantu, R., McKee, A. Tags: Neuro Trauma and Sports Neurology II Source Type: research

HELIAD study: Dementia prevalence in Greece (P3.095)
Conclusions:The prevalence of dementia and its subtypes in Greece is similar or at the lower range of that reported in many other European countries and globally. In our sample, increased age and decreased level of education status, but not gender, were predictive of a diagnosis of dementia with age being the strongest predictive factor.Study Supported by:Funding/Support: IIRG-09-133014 from the Alzheimer’s Association; 189 10276/8/9/2011 from the ESPA-EU program Excellence Grant (ARISTEIA) which is co-funded by the European Social Fund and Greek National resources; and Y2β/o.51657/14.4.2009 from the Ministry fo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Sakka, P., Kosmidis, M., Yannakoulia, M., Dardiotis, E., Hadjigeorgiou, G., Scarmeas, N. Tags: Aging and Dementia: Epidemiologic Studies Source Type: research

Associations between Parkinson Disease and Stroke (S51.006)
Conclusions:Among Medicare beneficiaries, the relationships between stroke and PD were similar to those between stroke and AD. As in AD, a link may exist between cerebrovascular disease and PD.Study Supported by: Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund. Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke.Disclosure: Dr. Kummer has nothing to disclose. Dr. Aaroe has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel h...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kummer, B., Aaroe, A., Kamel, H., Iadecola, C., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Late treatment with choline alfoscerate increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment (P1.229)
Conclusions:The present study suggests that application of α-GPC after seizure may serve as a beneficial treatment for improvement of cognitive function in epilepsy patientsDisclosure: Dr. Yoo has nothing to disclose. Dr. Shin has nothing to disclose. Dr. Lee has nothing to disclose. Dr. SONG has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yoo, J., Shin, D. J., Lee, B., SONG, H. Tags: Epilepsy and Clinical Neurophysiology: Basic Science Source Type: research

Harmonizing Together: Speech and Music Therapy and Support for Patients and Partners with PPA (P5.157)
Conclusions:The reports of improvement in caregiver health, social participation of patients, and functional communication are in line with the group’s focus and goals. In contrast, more comprehensive knowledge of the disease process may have led patients and caregivers to experience greater feelings of guilt and fear. Our qualitative observations and reports from participants indicated that the most beneficial parts of the group were raising patients’ confidence in communication and allowing both patients and families suffering from PPA to connect with one another.Study Supported by:Funding NIH grant NS077059;...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Quimby, M., Shaprio-Gordon, J., Brandt, K., Hyatt, C., Grimm, M., Richardson, L., Howland, K., Dickerson, B. Tags: Clinical Neuro-rehabilitation Source Type: research

CSF biomarkers suggest a strong role of glial inflammation in the pathogenesis of frontotemporal dementia (P6.104)
Conclusions:FTD features increased YKL-40, sTREM2 and NfL, a profile that distinguishes it from controls and AD. The dynamic relationship between CSF neuroinflammatory and injury biomarkers and disease severity support a strong role for neuroinflammation in the progression of FTD.Study Supported by:NIH 2T32 AG023481, National Institutes of Health, 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI, AG03879); the National Center for Advancing Translational Science (NCATS) and National Institute of Neurological Disorders and Stroke (NINDS), Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL, NS09208...
Source: Neurology - April 17, 2017 Category: Neurology Authors: -Martinez, J. R., Calvet, M. S., Karydas, A., Kleinberger, G., Kramer, J., Rosen, H., Rabinovici, G., Miller, B., Fagan, A., Haass, C., Boxer, A. Tags: Aging and Dementia Poster Discussion Session: Novel Approaches in Neurodegenerative Diseases: Genetics, Biomarkers, and Therapies Source Type: research

Elevated cerebrospinal fluid total Tau levels reflects predominant cortical involvement in Alzheimers disease (P1.093)
Conclusions:Elevated CSF Tau levels in AD patients could be surrogate biomarker for AD subtypes with predominant early cortical symptoms and atrophy. There is a need for a systematic prospective unbiased follow-up to see if rapid clinical progression in AD is related to elevated T-Tau and distinct AD subtypes.Disclosure: Dr. Pillai has nothing to disclose. Dr. Khrestian has nothing to disclose. Dr. Bekris has nothing to disclose. Dr. Safar has nothing to disclose. Dr. Leverenz has received personal compensation for activities with Axovant, GE Healthcare and Navidea Biopharmaceuticals as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pillai, J., Khrestian, M., Bekris, L., Safar, J., Leverenz, J. Tags: Aging and Dementia: Biomarkers Source Type: research

Novel quantitative imaging markers for understanding cognitive reserve in subdural hematoma (SDH) patients (P5.037)
Conclusions:Quantitative imaging can be used to predict functional outcomes in patients with intracranial hemorrhages. As we continue enrollment we hope to generate meaningful novel markers of cognitive reserve and recovery in patients with intracranial hemorrhages and other pathologies like acute stroke and brain tumors.Disclosure: Dr. Dangayach has nothing to disclose. Dr. Nicol has nothing to disclose. Dr. Sobotka has nothing to disclose. Dr. Griffiths has nothing to disclose. Dr. Costa has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Mayer has received personal compensation for activities with Bard Medical...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Dangayach, N., Nicol, K., Sobotka, S., Griffiths, S., Costa, A., Lee, J., Mayer, S., Frontera, J., Gordon, E., Bederson, J. Tags: Neurocritical Care: Coma/Mental Status Source Type: research

Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study
Conclusions: Our results do not provide strong evidence for a protective association between postmenopausal HT use and AD or dementia, although we observed a reduced AD risk among those with long-term self-reported HT use.
Source: Neurology - March 12, 2017 Category: Neurology Authors: Imtiaz, B., Tuppurainen, M., Rikkonen, T., Kivipelto, M., Soininen, H., Kröger, H., Tolppanen, A.-M. Tags: Alzheimer's disease, Cohort studies ARTICLE Source Type: research

Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings
18F-AV-1451 is a tau PET radioligand, characterized by high affinity for paired helical filaments (PHF) of hyperphosphorylated tau in neurofibrillary tangles (NFTs). Postmortem tissue studies have shown AV-1451 binding selectively to tau (3R + 4R isoforms) but not β-amyloid pathology.1–3 Human studies evaluating AV-1451 tracer retention in aging and Alzheimer disease (AD) have indicated that in vivo binding patterns parallel existing neuropathologic staging of tau.4,5
Source: Neurology - March 12, 2017 Category: Neurology Authors: Lockhart, S. N., Ayakta, N., Winer, J. R., La Joie, R., Rabinovici, G. D., Jagust, W. J. Tags: MRI, PET, Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke, Alzheimer's disease CLINICAL/SCIENTIFIC NOTES Source Type: research

Pages: 1  2  3  4  5  6  7